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1 to 25 of 360  Show
  1. 1
    "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 8137 other entries.

  2. 2
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).
  3. 3
    "Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes."
    Koch M., Rett K., Volk A., Maerker E., Haist K., Deninger M., Renn W., Haring H.U.
    Exp. Clin. Endocrinol. Diabetes 107:318-322(1999) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Not Associated with METABOLIC: diabetes, type 2.Imported.
    Source: GAD:128872.

    This publication is mapped to 7 other entries.

  4. 4
    "Candidate gene analysis in premature pubarche and adolescent hyperandrogenism."
    Witchel S.F., Smith R., Tomboc M., Aston C.E.
    Fertil. Steril. 75:724-730(2001) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:3667.

    This publication is mapped to 105 other entries.

  5. 5
    "The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans."
    Stumvoll M., Fritsche A., Volk A., Stefan N., Madaus A., Maerker E., Teigeler A., Koch M., Machicao F., Haring H.
    Diabetes 50:882-885(2001) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech, Sequences.
    Annotation: Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:3667.

    This publication is mapped to 7 other entries.

  6. 6
    "The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin-resistance."
    Baroni M.G., Arca M., Sentinelli F., Buzzetti R., Capici F., Lovari S., Vitale M., Romeo S., Di Mario U.
    Diabetologia 44:367-372(2001) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Observational study of gene-disease association. (HuGE Navigator)Imported, Associated with METABOLIC: body fat; insulin resistance.Imported.
    Source: GeneRIF:3667, GAD:128905.

    This publication is mapped to 7 other entries.

  7. 7
    "Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome."
    El Mkadem S.A., Lautier C., Macari F., Molinari N., Lefebvre P., Renard E., Gris J.C., Cros G., Daures J.P., Bringer J., White M.F., Grigorescu F.
    Diabetes 50:2164-2168(2001) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Associated with METABOLIC: polycystic ovarian syndrome; insulin resistance.Imported, Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:3667, GAD:128906.

    This publication is mapped to 14 other entries.

  8. 8
    "The mutation of insulin receptor substrate-1 gene in Chinese patients with non-insulin-dependent diabetes mellitus."
    Zeng W., Peng J., Wan X., Chen S., Song H.
    Chin. Med. J. 113:80-83(2000) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Associated with METABOLIC: diabetes, type 2.Imported, Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:3667, GAD:128907.

    This publication is mapped to 7 other entries.

  9. 9
    "Variations in insulin secretion in carriers of gene variants in IRS-1 and -2."
    't Hart L.M., Nijpels G., Dekker J.M., Maassen J.A., Heine R.J., van Haeften T.W.
    Diabetes 51:884-887(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Not Associated with METABOLIC: insulin secretion.Imported, Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:3667, GAD:128908.

    This publication is mapped to 14 other entries.

  10. 10
    "The Gly972Arg polymorphism in insulin receptor substrate-1 is associated with decreased birth weight in a population-based sample of Brazilian newborns."
    Bezerra R.M., de Castro V., Sales T., Passini R. Jr., Marba S.T., Saad S.T., Saad M.J.
    Diabetes Care 25:550-553(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: association between the Gly972Arg polymorphism in insulin receptor substrate-1 (IRS-1) and birth weight in a population-based sample of Brazilian newborns; Observational study of gene-disease association. (HuGE Navigator)Imported, Associated with REPRODUCTION: birth weight.Imported.
    Source: GeneRIF:3667, GAD:128896.

    This publication is mapped to 7 other entries.

  11. 11
    "Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen."
    Lassak A., Del Valle L., Peruzzi F., Wang J.Y., Enam S., Croul S., Khalili K., Reiss K.
    J. Biol. Chem. 277:17231-17238(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigenImported.
    Source: GeneRIF:3667.

    This publication is mapped to 10 other entries.

  12. 12
    "Nitric oxide regulates oestrogen-activated signalling pathways at multiple levels through cyclic GMP-dependent recruitment of insulin receptor substrate 1."
    Falcone S., Mauro L., de Rose G., Paolucci C., Sciorati C., Ando S., Clementi E.
    Biochem. J. 366:165-173(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Nitric oxide regulates oestrogen-activated signalling pathways at multiple levels through cyclic GMP-dependent recruitment of insulin receptor substrate 1 in human breast cancer cells.Imported.
    Source: GeneRIF:3667.

    This publication is mapped to 7 other entries.

  13. 13
    "Insulin sensitivity of glucose disposal and lipolysis: no influence of common genetic variants in IRS-1 and CAPN10."
    Stumvoll M., Wahl H.G., Machicao F., Haring H.
    Diabetologia 45:651-656(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: insulin sensitivity of glucose disposal and lipolysis: no influence of common genetic variants; Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:3667.

    This publication is mapped to 7 other entries.

  14. 14
    "Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome."
    Ehrmann D.A., Tang X., Yoshiuchi I., Cox N.J., Bell G.I.
    J. Clin. Endocrinol. Metab. 87:4297-4300(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Relationship of genotypes to phenotypic features of polycystic ovary syndrome; Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:3667.

    This publication is mapped to 14 other entries.

  15. 15
    "Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex."
    Gao Z., Hwang D., Bataille F., Lefevre M., York D., Quon M.J., Ye J.
    J. Biol. Chem. 277:48115-48121(2002) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: IRS-1 is a novel direct substrate for IKK and that phosphorylation of IRS-1 at Ser(312) (and other sites) by IKK may contribute to the insulin resistance mediated by activation of inflammatory pathwaysImported.
    Source: GeneRIF:3667.

    This publication is mapped to 8 other entries.

  16. 16
    "Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells."
    Bompard G., Puech C., Prebois C., Vignon F., Freiss G.
    J. Biol. Chem. 277:47861-47869(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: PTPL1/FAP-1 has a key role in the apoptotic process in human breast cancer cells independent of Fas but associated with an early inhibition of the insulin receptor substrate-1/phosphatidylinositol 3-kinase pathwayImported.
    Source: GeneRIF:3667.

    This publication is mapped to 11 other entries.

  17. 17
    "Genetic variants of insulin receptor substrate-1 (IRS-1) in syndromes of severe insulin resistance. Functional analysis of Ala513Pro and Gly1158Glu IRS-1."
    Berger D., Barroso I., Soos M., Yeo G., Schafer A.J., O'Rahilly S., Whitehead J.P.
    Diabet. Med. 19:804-809(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:3667.

    This publication is mapped to 7 other entries.

  18. 18
    "Common variants in the lipoprotein lipase gene, but not those in the insulin receptor substrate-1, the beta3-adrenergic receptor, and the intestinal fatty acid binding protein-2 genes, influence the lipid phenotypic expression in familial combined hyperlipidemia."
    Campagna F., Montali A., Baroni M.G., Maria A.T., Ricci G., Antonini R., Verna R., Arca M.
    Metab. Clin. Exp. 51:1298-1305(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: genetic variants in the gene appear not to have a major role as modifier genes in familial combined hyperlipidemiaImported.
    Source: GeneRIF:3667.

    This publication is mapped to 22 other entries.

  19. 19
    "Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells."
    Jiang G., Dallas-Yang Q., Liu F., Moller D.E., Zhang B.B.
    J. Biol. Chem. 278:180-186(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function, PTM / Processing.
    Annotation: Data suggest that salicylic acid can reverse the inhibitory effects of TNFalpha on insulin signaling via insulin receptor substrate 1Imported.
    Source: GeneRIF:3667.

    This publication is mapped to 7 other entries.

  20. 20
    "Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications."
    Chang Q., Li Y., White M.F., Fletcher J.A., Xiao S.
    Cancer Res. 62:6035-6038(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Constitutive IRS-1 activation is a common phenomenon in tumors.Imported.
    Source: GeneRIF:3667.

    This publication is mapped to 7 other entries.

  21. 21
    "Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms."
    Le Fur S., Le Stunff C., Bougneres P.
    Diabetes 51 Suppl 3:S304-7(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: In two cohorts ofobese Caucasian children we measured insulin sensitivity and genotyped insulin receptor substrate IRS-1 and IRS-2 genes for the Arg972Gly and the Asp1057Gly variants respectively; Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:3667.

    This publication is mapped to 14 other entries.

  22. 22
    "Increased frequency of the G972R variant of the insulin receptor substrate-1 (irs-1) gene among girls with a history of precocious pubarche."
    Ibanez L., Marcos M.V., Potau N., White C., Aston C.E., Witchel S.F.
    Fertil. Steril. 78:1288-1293(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: Observational study of gene-disease association. (HuGE Navigator); Increased frequency of the G972R variant of the insulin receptor substrate-1 (irs-1) gene among girls with a history of precocious pubarche. Sex hormone-binding globulin concentrations were lower among girls heterozygous for G972R variant.Imported.
    Source: GeneRIF:3667.

    This publication is mapped to 7 other entries.

  23. 23
    "Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor."
    Wick K.R., Werner E.D., Langlais P., Ramos F.J., Dong L.Q., Shoelson S.E., Liu F.
    J. Biol. Chem. 278:8460-8467(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: inhibition of insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by Grb10Imported.
    Source: GeneRIF:3667.

    This publication is cited by 1 and mapped to 42 other entries.

  24. 24
    "Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation."
    Greene M.W., Sakaue H., Wang L., Alessi D.R., Roth R.A.
    J. Biol. Chem. 278:8199-8211(2003) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: role in modulating insulin-stimulated degradation by serine 312 phosphorylationImported.
    Source: GeneRIF:3667.

    This publication is mapped to 7 other entries.

  25. 25
    "BCR-ABL binds to IRS-1 and IRS-1 phosphorylation is inhibited by imatinib in K562 cells."
    Traina F., Carvalheira J.B., Saad M.J., Costa F.F., Saad S.T.
    FEBS Lett. 535:17-22(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: concluded that the IRS-1 protein is involved in the signalling pathway of the BCR-ABL tyrosine kinaseImported.
    Source: GeneRIF:3667.

    This publication is mapped to 56 other entries.

1 to 25 of 360  Show
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