UniProtKB - A0A024R475 (A0A024R475_HUMAN)
Protein
Submitted name:
Cullin 3, isoform CRA_a
Gene
CUL3
Organism
Homo sapiens (Human)
Status
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- cyclin binding Source: Ensembl
- ubiquitin protein ligase binding Source: InterPro
GO - Biological processi
- embryonic cleavage Source: Ensembl
- fibroblast apoptotic process Source: Ensembl
- gastrulation Source: Ensembl
- integrin-mediated signaling pathway Source: Ensembl
- liver morphogenesis Source: Ensembl
- mitotic cell cycle Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: Ensembl
- protein polyubiquitination Source: Ensembl
- stem cell division Source: Ensembl
- trophectodermal cellular morphogenesis Source: Ensembl
- Wnt signaling pathway Source: Ensembl
Keywordsi
Biological process | Ubl conjugation pathwayARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Submitted name: Cullin 3, isoform CRA_aImported |
Gene namesi | Name:CUL3Imported ORF Names:hCG_21435Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000036257.12 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nucleus Source: Ensembl
Other locations
- cullin-RING ubiquitin ligase complex Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSG00000036257, Expressed in sperm and 240 other tissues |
ExpressionAtlasi | A0A024R475, baseline and differential |
Interactioni
GO - Molecular functioni
- cyclin binding Source: Ensembl
- ubiquitin protein ligase binding Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 383 – 635 | CULLIN_2InterPro annotationAdd BLAST | 253 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 677 – 698 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 682 – 698 | PolyampholyteSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Phylogenomic databases
OMAi | EIHTKNA |
PhylomeDBi | A0A024R475 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR016157, Cullin_CS IPR016158, Cullin_homology IPR036317, Cullin_homology_sf IPR001373, Cullin_N IPR019559, Cullin_neddylation_domain IPR016159, Cullin_repeat-like_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00888, Cullin, 1 hit PF10557, Cullin_Nedd8, 1 hit |
SMARTi | View protein in SMART SM00182, CULLIN, 1 hit SM00884, Cullin_Nedd8, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF74788, SSF74788, 1 hit SSF75632, SSF75632, 1 hit |
PROSITEi | View protein in PROSITE PS01256, CULLIN_1, 1 hit PS50069, CULLIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R475-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNLSKGTGS RKDTKMRIRA FPMTMDEKYV NSIWDLLKNA IQEIQRKNNS
60 70 80 90 100
GLSFEELYRN AYTMVLHKHG EKLYTGLREV VTEHLINKVR EDVLNSLNNN
110 120 130 140 150
FLQTLNQAWN DHQTAMVMIR DILMYMDRVY VQQNNVENVY NLGLIIFRDQ
160 170 180 190 200
VVRYGCIRDH LRQTLLDMIA RERKGEVVDR GAIRNACQML MILGLEGRSV
210 220 230 240 250
YEEDFEAPFL EMSAEFFQME SQKFLAENSA SVYIKKVEAR INEEIERVMH
260 270 280 290 300
CLDKSTEEPI VKVVERELIS KHMKTIVEME NSGLVHMLKN GKTEDLGCMY
310 320 330 340 350
KLFSRVPNGL KTMCECMSSY LREQGKALVS EEGEGKNPVD YIQGLLDLKS
360 370 380 390 400
RFDRFLLESF NNDRLFKQTI AGDFEYFLNL NSRSPEYLSL FIDDKLKKGV
410 420 430 440 450
KGLTEQEVET ILDKAMVLFR FMQEKDVFER YYKQHLARRL LTNKSVSDDS
460 470 480 490 500
EKNMISKLKT ECGCQFTSKL EGMFRDMSIS NTTMDEFRQH LQATGVSLGG
510 520 530 540 550
VDLTVRVLTT GYWPTQSATP KCNIPPAPRH AFEIFRRFYL AKHSGRQLTL
560 570 580 590 600
QHHMGSADLN ATFYGPVKKE DGSEVGVGGA QVTGSNTRKH ILQVSTFQMT
610 620 630 640 650
ILMLFNNREK YTFEEIQQET DIPERELVRA LQSLACGKPT QRVLTKEPKS
660 670 680 690 700
KEIENGHIFT VNDQFTSKLH RVKIQTVAAK QGESDPERKE TRQKVDDDRK
710 720 730 740 750
HEIEAAIVRI MKSRKKMQHN VLVAEVTQQL KARFLPSPVV IKKRIEGLIE
760
REYLARTPED RKVYTYVA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471063 Genomic DNA Translation: EAW70830.1 |
RefSeqi | NP_003581.1, NM_003590.4 |
Genome annotation databases
GeneIDi | 8452 |
KEGGi | hsa:8452 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471063 Genomic DNA Translation: EAW70830.1 |
RefSeqi | NP_003581.1, NM_003590.4 |
3D structure databases
SMRi | A0A024R475 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 3632, 390 antibodies |
DNASUi | 8452 |
Genome annotation databases
GeneIDi | 8452 |
KEGGi | hsa:8452 |
Organism-specific databases
CTDi | 8452 |
VEuPathDBi | HostDB:ENSG00000036257.12 |
Phylogenomic databases
OMAi | EIHTKNA |
PhylomeDBi | A0A024R475 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Miscellaneous databases
BioGRID-ORCSi | 8452, 493 hits in 1025 CRISPR screens |
ChiTaRSi | CUL3, human |
GenomeRNAii | 8452 |
Gene expression databases
Bgeei | ENSG00000036257, Expressed in sperm and 240 other tissues |
ExpressionAtlasi | A0A024R475, baseline and differential |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR016157, Cullin_CS IPR016158, Cullin_homology IPR036317, Cullin_homology_sf IPR001373, Cullin_N IPR019559, Cullin_neddylation_domain IPR016159, Cullin_repeat-like_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00888, Cullin, 1 hit PF10557, Cullin_Nedd8, 1 hit |
SMARTi | View protein in SMART SM00182, CULLIN, 1 hit SM00884, Cullin_Nedd8, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF74788, SSF74788, 1 hit SSF75632, SSF75632, 1 hit |
PROSITEi | View protein in PROSITE PS01256, CULLIN_1, 1 hit PS50069, CULLIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R475_HUMAN | |
Accessioni | A0A024R475Primary (citable) accession number: A0A024R475 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 43 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |