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Protein

Autophagy-related protein 9

Gene

ATG9A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Biological processi

Keywordsi

Biological processAutophagyUniRule annotation, Protein transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 9UniRule annotation
Gene namesi
Name:ATG9AImported
ORF Names:hCG_15583Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000198925.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei70 – 92HelicalUniRule annotationAdd BLAST23
Transmembranei290 – 314HelicalUniRule annotationAdd BLAST25
Transmembranei380 – 397HelicalUniRule annotationAdd BLAST18
Transmembranei404 – 425HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Cytoplasmic vesicleUniRule annotation, Golgi apparatusUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PRIDEiA0A024R438

Expressioni

Gene expression databases

BgeeiENSG00000198925 Expressed in 212 organ(s), highest expression level in testis
ExpressionAtlasiA0A024R438 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A024R438
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG9 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2173 Eukaryota
ENOG410XQBE LUCA
KOiK17907
OMAiKFFVQLR
OrthoDBiEOG091G01WQ
PhylomeDBiA0A024R438

Family and domain databases

InterProiView protein in InterPro
IPR007241 Autophagy-rel_prot_9
PANTHERiPTHR13038 PTHR13038, 1 hit
PfamiView protein in Pfam
PF04109 APG9, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024R438-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV
60 70 80 90 100
YNLHQKNGFT CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH
110 120 130 140 150
SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF
160 170 180 190 200
IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK
210 220 230 240 250
RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEA VFFTRGLKYN
260 270 280 290 300
FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL
310 320 330 340 350
CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL
360 370 380 390 400
QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED
410 420 430 440 450
VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD
460 470 480 490 500
HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL LSPIVTPLIL IFCLRPRALE
510 520 530 540 550
IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSAGQT EASVYQQAED
560 570 580 590 600
GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA ASLAQGGLLP
610 620 630 640 650
ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLPRDLQ GSRHRAEVAS
660 670 680 690 700
ALRSFSPLQP GQAPTGRAHS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE
710 720 730 740 750
YASTEMSLHA LYMHQLHKQQ AQAEPERHVW HRRESDESGE SAPDEGGEGA
760 770 780 790 800
RAPQSIPRSA SYPCAAPRPG APETTALHGG FQRRYGGITD PGTVPRVPSH
810 820 830
FSRLPLGGWA EDGQSASRHP EPVPEEGSED ELPPQVHKV
Length:839
Mass (Da):94,447
Last modified:July 9, 2014 - v1
Checksum:i69BE087CA550DC42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471063 Genomic DNA Translation: EAW70707.1
RefSeqiNP_001070666.1, NM_001077198.2
NP_076990.4, NM_024085.4
UniGeneiHs.323363

Genome annotation databases

GeneIDi79065
KEGGihsa:79065

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471063 Genomic DNA Translation: EAW70707.1
RefSeqiNP_001070666.1, NM_001077198.2
NP_076990.4, NM_024085.4
UniGeneiHs.323363

3D structure databases

ProteinModelPortaliA0A024R438
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA0A024R438

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79065
KEGGihsa:79065

Organism-specific databases

CTDi79065
EuPathDBiHostDB:ENSG00000198925.10

Phylogenomic databases

eggNOGiKOG2173 Eukaryota
ENOG410XQBE LUCA
KOiK17907
OMAiKFFVQLR
OrthoDBiEOG091G01WQ
PhylomeDBiA0A024R438

Miscellaneous databases

ChiTaRSiATG9A human
GenomeRNAii79065

Gene expression databases

BgeeiENSG00000198925 Expressed in 212 organ(s), highest expression level in testis
ExpressionAtlasiA0A024R438 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR007241 Autophagy-rel_prot_9
PANTHERiPTHR13038 PTHR13038, 1 hit
PfamiView protein in Pfam
PF04109 APG9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R438_HUMAN
AccessioniPrimary (citable) accession number: A0A024R438
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 12, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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