UniProtKB - A0A024R3Y4 (A0A024R3Y4_HUMAN)
Protein
Submitted name:
CASP8 and FADD-like apoptosis regulator, isoform CRA_c
Gene
CFLAR
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
- death receptor binding Source: Ensembl
- peptidase activator activity Source: Ensembl
- protease binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- cellular response to dexamethasone stimulus Source: Ensembl
- cellular response to epidermal growth factor stimulus Source: Ensembl
- cellular response to estradiol stimulus Source: Ensembl
- cellular response to hypoxia Source: Ensembl
- cellular response to insulin stimulus Source: Ensembl
- cellular response to nitric oxide Source: Ensembl
- negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
- negative regulation of cellular response to transforming growth factor beta stimulus Source: Ensembl
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of hepatocyte apoptotic process Source: Ensembl
- negative regulation of myoblast fusion Source: Ensembl
- negative regulation of necroptotic process Source: Ensembl
- negative regulation of reactive oxygen species biosynthetic process Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of extracellular matrix organization Source: Ensembl
- positive regulation of glomerular mesangial cell proliferation Source: Ensembl
- positive regulation of hepatocyte proliferation Source: Ensembl
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: Ensembl
- regulation of skeletal muscle satellite cell proliferation Source: Ensembl
- response to bacterium Source: Ensembl
- response to testosterone Source: Ensembl
- skeletal muscle atrophy Source: Ensembl
- skeletal muscle tissue development Source: Ensembl
- skeletal muscle tissue regeneration Source: Ensembl
- skeletal myofibril assembly Source: Ensembl
- wound healing Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: CASP8 and FADD-like apoptosis regulator, isoform CRA_cImportedSubmitted name: Testis secretory sperm-binding protein Li 233mImported |
Gene namesi | Name:CFLARImported ORF Names:hCG_16553Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000003402.19 |
Subcellular locationi
Plasma Membrane
- CD95 death-inducing signaling complex Source: Ensembl
Other locations
- cytoplasm Source: Ensembl
- membrane raft Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000003402, Expressed in lower esophagus muscularis layer and 240 other tissues |
Interactioni
GO - Molecular functioni
- death receptor binding Source: Ensembl
- protease binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 73 | DEDInterPro annotationAdd BLAST | 73 | |
Domaini | 92 – 170 | DEDInterPro annotationAdd BLAST | 79 | |
Domaini | 263 – 358 | CASPASE_P20InterPro annotationAdd BLAST | 96 |
Sequence similaritiesi
Belongs to the peptidase C14A family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
OMAi | VYDWNSR |
OrthoDBi | 939331at2759 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 2 hits |
SMARTi | View protein in SMART SM00115, CASc, 1 hit SM00031, DED, 2 hits |
SUPFAMi | SSF47986, SSF47986, 2 hits SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50208, CASPASE_P20, 1 hit PS50168, DED, 2 hits |
i Sequence
Sequence statusi: Complete.
A0A024R3Y4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL
60 70 80 90 100
SVGDLAELLY RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI
110 120 130 140 150
GEDLDKSDVS SLIFLMKDYM GRGKISKEKS FLDLVVELEK LNLVAPDQLD
160 170 180 190 200
LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT SYRNVLQAAI QKSLKDPSNN
210 220 230 240 250
FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP EERYKMKSKP
260 270 280 290 300
LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
310 320 330 340 350
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG
360 370 380 390 400
KPKMFFIQNY VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD
410 420 430 440 450
FFWSLCTADM SLLEQSHSSP SLYLQCLSQK LRQERKRPLL DLHIELNGYM
460 470 480
YDWNSRVSAK EKYYVWLQHT LRKKLILSYT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005351 mRNA Translation: AEE60951.1 CH471063 Genomic DNA Translation: EAW70243.1 CH471063 Genomic DNA Translation: EAW70245.1 |
RefSeqi | NP_001120655.1, NM_001127183.2 NP_003870.4, NM_003879.5 XP_016860679.1, XM_017005190.1 XP_016860680.1, XM_017005191.1 |
Genome annotation databases
GeneIDi | 8837 |
KEGGi | hsa:8837 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005351 mRNA Translation: AEE60951.1 CH471063 Genomic DNA Translation: EAW70243.1 CH471063 Genomic DNA Translation: EAW70245.1 |
RefSeqi | NP_001120655.1, NM_001127183.2 NP_003870.4, NM_003879.5 XP_016860679.1, XM_017005190.1 XP_016860680.1, XM_017005191.1 |
3D structure databases
SMRi | A0A024R3Y4 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 19934, 924 antibodies |
Genome annotation databases
GeneIDi | 8837 |
KEGGi | hsa:8837 |
Organism-specific databases
CTDi | 8837 |
EuPathDBi | HostDB:ENSG00000003402.19 |
Phylogenomic databases
OMAi | VYDWNSR |
OrthoDBi | 939331at2759 |
Miscellaneous databases
BioGRID-ORCSi | 8837, 322 hits in 845 CRISPR screens |
ChiTaRSi | CFLAR, human |
GenomeRNAii | 8837 |
Gene expression databases
Bgeei | ENSG00000003402, Expressed in lower esophagus muscularis layer and 240 other tissues |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 2 hits |
SMARTi | View protein in SMART SM00115, CASc, 1 hit SM00031, DED, 2 hits |
SUPFAMi | SSF47986, SSF47986, 2 hits SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50208, CASPASE_P20, 1 hit PS50168, DED, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R3Y4_HUMAN | |
Accessioni | A0A024R3Y4Primary (citable) accession number: A0A024R3Y4 Secondary accession number(s): A0A024R3Z7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 11, 2019 |
Last sequence update: | December 11, 2019 | |
Last modified: | December 2, 2020 | |
This is version 7 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |