UniProtKB - A0A024R3W1 (A0A024R3W1_HUMAN)
Protein
Muscarinic acetylcholine receptor
Gene
CHRM3
Organism
Homo sapiens (Human)
Status
Functioni
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.UniRule annotation
GO - Molecular functioni
- acetylcholine binding Source: Ensembl
- G protein-coupled acetylcholine receptor activity Source: UniProtKB-UniRule
GO - Biological processi
- negative regulation of heart rate by acetylcholine Source: Ensembl
- positive regulation of vascular associated smooth muscle contraction Source: Ensembl
- saliva secretion Source: Ensembl
- smooth muscle contraction Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Muscarinic acetylcholine receptorUniRule annotation |
Gene namesi | Name:CHRM3Imported ORF Names:hCG_1641761Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma membrane
- Basolateral cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
- postsynaptic cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB-SubCell
- integral component of postsynaptic density membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
Other locations
- axon terminus Source: Ensembl
- dendrite Source: Ensembl
- glutamatergic synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 65 – 93 | HelicalUniRule annotationAdd BLAST | 29 | |
Transmembranei | 105 – 131 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 143 – 164 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 185 – 210 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 230 – 252 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 489 – 509 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 529 – 547 | HelicalUniRule annotationAdd BLAST | 19 |
Keywords - Cellular componenti
Cell junction, Cell membraneUniRule annotationARBA annotation, Membrane, Postsynaptic cell membraneUniRule annotation, SynapseFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 85 – 544 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 460 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 323 – 357 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 323 – 352 | PolarSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
OMAi | VIFHKRI |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001183, Musac_Ach_M3_rcpt IPR000995, Musac_Ach_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00243, MUSCARINICR PR00540, MUSCRINICM3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R3W1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLHNNSTTS PLFPNISSSW IHSPSDAGLP PGTVTHFGSY NVSRAAGNFS
60 70 80 90 100
SPDGTTDDPL GGHTVWQVVF IAFLTGILAL VTIIGNILVI VSFKVNKQLK
110 120 130 140 150
TVNNYFLLSL ACADLIIGVI SMNLFTTYII MNRWALGNLA CDLWLAIDYV
160 170 180 190 200
ASNASVMNLL VISFDRYFSI TRPLTYRAKR TTKRAGVMIG LAWVISFVLW
210 220 230 240 250
APAILFWQYF VGKRTVPPGE CFIQFLSEPT ITFGTAIAAF YMPVTIMTIL
260 270 280 290 300
YWRIYKETEK RTKELAGLQA SGTEAETENF VHPTGSSRSC SSYELQQQSM
310 320 330 340 350
KRSNRRKYGR CHFWFTTKSW KPSSEQMDQD HSSSDSWNNN DAAASLENSA
360 370 380 390 400
SSDEEDIGSE TRAIYSIVLK LPGHSTILNS TKLPSSDNLQ VPEEELGMVD
410 420 430 440 450
LERKADKLQA QKSVDDGGSF PKSFSKLPIQ LESAVDTAKT SDVNSSVGKS
460 470 480 490 500
TATLPLSFKE ATLAKRFALK TRSQITKRKR MSLVKEKKAA QTLSAILLAF
510 520 530 540 550
IITWTPYNIM VLVNTFCDSC IPKTFWNLGY WLCYINSTVN PVCYALCNKT
560 570 580 590
FRTTFKMLLL CQCDKKKRRK QQYQQRQSVI FHKRAPEQAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471098 Genomic DNA Translation: EAW70076.1 CH471098 Genomic DNA Translation: EAW70077.1 CH471098 Genomic DNA Translation: EAW70078.1 |
RefSeqi | NP_000731.1, NM_000740.3 NP_001334645.1, NM_001347716.1 XP_005273089.1, XM_005273032.3 XP_011542343.1, XM_011544041.2 XP_011542345.1, XM_011544043.2 XP_011542346.1, XM_011544044.2 XP_011542348.1, XM_011544046.2 XP_011542349.1, XM_011544047.2 XP_016855641.1, XM_017000152.1 XP_016855642.1, XM_017000153.1 XP_016855643.1, XM_017000154.1 XP_016855644.1, XM_017000155.1 XP_016855645.1, XM_017000156.1 XP_016855646.1, XM_017000157.1 XP_016855647.1, XM_017000158.1 XP_016855648.1, XM_017000159.1 XP_016855649.1, XM_017000160.1 XP_016855650.1, XM_017000161.1 XP_016855651.1, XM_017000162.1 XP_016855652.1, XM_017000163.1 |
Genome annotation databases
GeneIDi | 1131 |
KEGGi | hsa:1131 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471098 Genomic DNA Translation: EAW70076.1 CH471098 Genomic DNA Translation: EAW70077.1 CH471098 Genomic DNA Translation: EAW70078.1 |
RefSeqi | NP_000731.1, NM_000740.3 NP_001334645.1, NM_001347716.1 XP_005273089.1, XM_005273032.3 XP_011542343.1, XM_011544041.2 XP_011542345.1, XM_011544043.2 XP_011542346.1, XM_011544044.2 XP_011542348.1, XM_011544046.2 XP_011542349.1, XM_011544047.2 XP_016855641.1, XM_017000152.1 XP_016855642.1, XM_017000153.1 XP_016855643.1, XM_017000154.1 XP_016855644.1, XM_017000155.1 XP_016855645.1, XM_017000156.1 XP_016855646.1, XM_017000157.1 XP_016855647.1, XM_017000158.1 XP_016855648.1, XM_017000159.1 XP_016855649.1, XM_017000160.1 XP_016855650.1, XM_017000161.1 XP_016855651.1, XM_017000162.1 XP_016855652.1, XM_017000163.1 |
3D structure databases
SMRi | A0A024R3W1 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024R3W1 |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
GeneIDi | 1131 |
KEGGi | hsa:1131 |
Organism-specific databases
CTDi | 1131 |
Phylogenomic databases
OMAi | VIFHKRI |
Miscellaneous databases
ChiTaRSi | CHRM3, human |
GenomeRNAii | 1131 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001183, Musac_Ach_M3_rcpt IPR000995, Musac_Ach_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00243, MUSCARINICR PR00540, MUSCRINICM3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R3W1_HUMAN | |
Accessioni | A0A024R3W1Primary (citable) accession number: A0A024R3W1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 11, 2019 |
Last sequence update: | December 11, 2019 | |
Last modified: | February 10, 2021 | |
This is version 8 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |