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UniProtKB - A0A024R3T8 (A0A024R3T8_HUMAN)
Protein
Poly [ADP-ribose] polymerase
Gene
PARP1
Organism
Homo sapiens (Human)
Status
Functioni
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
UniRule annotationCatalytic activityi
- L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamideARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamideARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- L-tyrosyl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.UniRule annotationARBA annotation EC:2.4.2.30
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- estrogen receptor binding Source: Ensembl
- histone deacetylase binding Source: Ensembl
- NAD+ ADP-ribosyltransferase activity Source: UniProtKB-UniRule
- NAD binding Source: UniProtKB-UniRule
- R-SMAD binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- cellular response to amyloid-beta Source: Ensembl
- cellular response to zinc ion Source: Ensembl
- DNA repair Source: UniProtKB-KW
- positive regulation of cardiac muscle hypertrophy Source: Ensembl
- positive regulation of intracellular estrogen receptor signaling pathway Source: Ensembl
- positive regulation of mitochondrial depolarization Source: Ensembl
- positive regulation of myofibroblast differentiation Source: Ensembl
- positive regulation of neuron death Source: Ensembl
- positive regulation of protein localization to nucleus Source: Ensembl
- positive regulation of SMAD protein signal transduction Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of transcription regulatory region DNA binding Source: Ensembl
- protein autoprocessing Source: Ensembl
- protein poly-ADP-ribosylation Source: Ensembl
- regulation of DNA methylation Source: Ensembl
- regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Source: Ensembl
- regulation of SMAD protein complex assembly Source: Ensembl
- response to aldosterone Source: Ensembl
- response to gamma radiation Source: Ensembl
- signal transduction involved in regulation of gene expression Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, GlycosyltransferaseUniRule annotationARBA annotation, Transferase |
Ligand | Metal-binding, NADUniRule annotationARBA annotation, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PARP1Imported ORF Names:hCG_14746Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000143799 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Other locations
- Chromosome UniRule annotation
Nucleus
- nuclear body Source: HPA
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
- chromosome Source: UniProtKB-SubCell
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
ChromosomeUniRule annotation, NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000143799, Expressed in ventricular zone and 247 other tissues |
ExpressionAtlasi | A0A024R3T8, baseline and differential |
Interactioni
GO - Molecular functioni
- estrogen receptor binding Source: Ensembl
- histone deacetylase binding Source: Ensembl
- R-SMAD binding Source: Ensembl
Chemistry databases
BindingDBi | A0A024R3T8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 93 | PARP-typeInterPro annotationAdd BLAST | 85 | |
Domaini | 113 – 203 | PARP-typeInterPro annotationAdd BLAST | 91 | |
Domaini | 385 – 461 | BRCTInterPro annotationAdd BLAST | 77 | |
Domaini | 662 – 779 | PARP alpha-helicalInterPro annotationAdd BLAST | 118 | |
Domaini | 788 – 1014 | PARP catalyticInterPro annotationAdd BLAST | 227 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 198 – 233 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 361 – 385 | DisorderedSequence analysisAdd BLAST | 25 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 429 – 456 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 366 – 385 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the ARTD/PARP family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerARBA annotationPhylogenomic databases
HOGENOMi | CLU_004841_0_0_1 |
OMAi | HTNIDDT |
OrthoDBi | 909382at2759 |
PhylomeDBi | A0A024R3T8 |
Family and domain databases
Gene3Di | 1.20.142.10, 1 hit 2.20.25.630, 1 hit 3.30.1740.10, 2 hits 3.40.50.10190, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR012982, PADR1 IPR038650, PADR1_dom_sf IPR008288, PARP IPR012317, Poly(ADP-ribose)pol_cat_dom IPR004102, Poly(ADP-ribose)pol_reg_dom IPR036616, Poly(ADP-ribose)pol_reg_dom_sf IPR036930, WGR_dom_sf IPR008893, WGR_domain IPR001510, Znf_PARP IPR036957, Znf_PARP_sf |
Pfami | View protein in Pfam PF00533, BRCT, 1 hit PF08063, PADR1, 1 hit PF00644, PARP, 1 hit PF02877, PARP_reg, 1 hit PF05406, WGR, 1 hit PF00645, zf-PARP, 2 hits |
PIRSFi | PIRSF000489, NAD_ADPRT, 1 hit |
SMARTi | View protein in SMART SM00292, BRCT, 1 hit SM01335, PADR1, 1 hit SM00773, WGR, 1 hit SM01336, zf-PARP, 2 hits |
SUPFAMi | SSF142921, SSF142921, 1 hit SSF47587, SSF47587, 1 hit SSF52113, SSF52113, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit PS51060, PARP_ALPHA_HD, 1 hit PS51059, PARP_CATALYTIC, 1 hit PS00347, PARP_ZN_FINGER_1, 1 hit PS50064, PARP_ZN_FINGER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
A0A024R3T8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH
60 70 80 90 100
WYHFSCFWKV GHSIRHPDVE VDGFSELRWD DQQKVKKTAE AGGVTGKGQD
110 120 130 140 150
GIGSKAEKTL GDFAAEYAKS NRSTCKGCME KIEKGQVRLS KKMVDPEKPQ
160 170 180 190 200
LGMIDRWYHP GCFVKNREEL GFRPEYSASQ LKGFSLLATE DKEALKKQLP
210 220 230 240 250
GVKSEGKRKG DEVDGVDEVA KKKSKKEKDK DSKLEKALKA QNDLIWNIKD
260 270 280 290 300
ELKKVCSTND LKELLIFNKQ QVPSGESAIL DRVADGMVFG ALLPCEECSG
310 320 330 340 350
QLVFKSDAYY CTGDVTAWTK CMVKTQTPNR KEWVTPKEFR EISYLKKLKV
360 370 380 390 400
KKQDRIFPPE TSASVAATPP PSTASAPAAV NSSASADKPL SNMKILTLGK
410 420 430 440 450
LSRNKDEVKA MIEKLGGKLT GTANKASLCI STKKEVEKMN KKMEEVKEAN
460 470 480 490 500
IRVVSEDFLQ DVSASTKSLQ ELFLAHILSP WGAEVKAEPV EVVAPRGKSG
510 520 530 540 550
AALSKKSKGQ VKEEGINKSE KRMKLTLKGG AAVDPDSGLE HSAHVLEKGG
560 570 580 590 600
KVFSATLGLV DIVKGTNSYY KLQLLEDDKE NRYWIFRSWG RVGTVIGSNK
610 620 630 640 650
LEQMPSKEDA IEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE
660 670 680 690 700
AVKKLTVNPG TKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK
710 720 730 740 750
LSKRQIQAAY SILSEVQQAV SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP
760 770 780 790 800
LLNNADSVQA KVEMLDNLLD IEVAYSLLRG GSDDSSKDPI DVNYEKLKTD
810 820 830 840 850
IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE REGECQRYKP
860 870 880 890 900
FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM
910 920 930 940 950
VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG
960 970 980 990 1000
LGKTTPDPSA NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK
1010
YLLKLKFNFK TSLW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471098 Genomic DNA Translation: EAW69784.1 |
RefSeqi | NP_001609.2, NM_001618.3 |
Genome annotation databases
GeneIDi | 142 |
KEGGi | hsa:142 |
MANE-Selecti | ENST00000366794.10; ENSP00000355759.5; NM_001618.4; NP_001609.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471098 Genomic DNA Translation: EAW69784.1 |
RefSeqi | NP_001609.2, NM_001618.3 |
3D structure databases
SMRi | A0A024R3T8 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024R3T8 |
Protocols and materials databases
Antibodypediai | 3545, 1898 antibodies from 50 providers |
DNASUi | 142 |
Genome annotation databases
GeneIDi | 142 |
KEGGi | hsa:142 |
MANE-Selecti | ENST00000366794.10; ENSP00000355759.5; NM_001618.4; NP_001609.2 |
Organism-specific databases
CTDi | 142 |
VEuPathDBi | HostDB:ENSG00000143799 |
Phylogenomic databases
HOGENOMi | CLU_004841_0_0_1 |
OMAi | HTNIDDT |
OrthoDBi | 909382at2759 |
PhylomeDBi | A0A024R3T8 |
Miscellaneous databases
BioGRID-ORCSi | 142, 27 hits in 1056 CRISPR screens |
ChiTaRSi | PARP1, human |
GenomeRNAii | 142 |
Gene expression databases
Bgeei | ENSG00000143799, Expressed in ventricular zone and 247 other tissues |
ExpressionAtlasi | A0A024R3T8, baseline and differential |
Family and domain databases
Gene3Di | 1.20.142.10, 1 hit 2.20.25.630, 1 hit 3.30.1740.10, 2 hits 3.40.50.10190, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR012982, PADR1 IPR038650, PADR1_dom_sf IPR008288, PARP IPR012317, Poly(ADP-ribose)pol_cat_dom IPR004102, Poly(ADP-ribose)pol_reg_dom IPR036616, Poly(ADP-ribose)pol_reg_dom_sf IPR036930, WGR_dom_sf IPR008893, WGR_domain IPR001510, Znf_PARP IPR036957, Znf_PARP_sf |
Pfami | View protein in Pfam PF00533, BRCT, 1 hit PF08063, PADR1, 1 hit PF00644, PARP, 1 hit PF02877, PARP_reg, 1 hit PF05406, WGR, 1 hit PF00645, zf-PARP, 2 hits |
PIRSFi | PIRSF000489, NAD_ADPRT, 1 hit |
SMARTi | View protein in SMART SM00292, BRCT, 1 hit SM01335, PADR1, 1 hit SM00773, WGR, 1 hit SM01336, zf-PARP, 2 hits |
SUPFAMi | SSF142921, SSF142921, 1 hit SSF47587, SSF47587, 1 hit SSF52113, SSF52113, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit PS51060, PARP_ALPHA_HD, 1 hit PS51059, PARP_CATALYTIC, 1 hit PS00347, PARP_ZN_FINGER_1, 1 hit PS50064, PARP_ZN_FINGER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R3T8_HUMAN | |
Accessioni | A0A024R3T8Primary (citable) accession number: A0A024R3T8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | January 19, 2022 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |