PARP1

Functionⁱ

Catalytic activityⁱ

NAD⁺ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.UniRule annotation

GO - Molecular functionⁱ

DNA binding Source: InterPro
estrogen receptor binding Source: Ensembl
histone deacetylase binding Source: Ensembl
NAD+ ADP-ribosyltransferase activity Source: UniProtKB-UniRule
NAD binding Source: Ensembl
R-SMAD binding Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to amyloid-beta Source: Ensembl
cellular response to zinc ion Source: Ensembl
DNA damage response, detection of DNA damage Source: Ensembl
positive regulation of cardiac muscle hypertrophy Source: Ensembl
positive regulation of intracellular estrogen receptor signaling pathway Source: Ensembl
positive regulation of mitochondrial depolarization Source: Ensembl
positive regulation of myofibroblast differentiation Source: Ensembl
positive regulation of neuron death Source: Ensembl
positive regulation of protein localization to nucleus Source: Ensembl
positive regulation of SMAD protein signal transduction Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of transcription regulatory region DNA binding Source: Ensembl
protein autoprocessing Source: Ensembl
protein poly-ADP-ribosylation Source: Ensembl
regulation of DNA methylation Source: Ensembl
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Source: Ensembl
regulation of SMAD protein complex assembly Source: Ensembl
response to aldosterone Source: Ensembl
response to gamma radiation Source: Ensembl
signal transduction involved in regulation of gene expression Source: Ensembl
transforming growth factor beta receptor signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GlycosyltransferaseUniRule annotation, Transferase
Ligand	NADUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.30UniRule annotation) Short name: PARPUniRule annotation
Gene namesⁱ	Name:PARP1Imported ORF Names:hCG_14746Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143799.12

EuPathDBⁱ

HostDB:ENSG00000143799.12

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	A0A024R3T8

PRIDEⁱ

A0A024R3T8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000143799
ExpressionAtlasⁱ	A0A024R3T8 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

estrogen receptor binding Source: Ensembl
histone deacetylase binding Source: Ensembl
R-SMAD binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A0A024R3T8
SMRⁱ	A0A024R3T8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	9 – 93	PARP-typeInterPro annotationAdd BLAST	85
Domainⁱ	113 – 203	PARP-typeInterPro annotationAdd BLAST	91
Domainⁱ	385 – 461	BRCTInterPro annotationAdd BLAST	77
Domainⁱ	662 – 779	PARP alpha-helicalInterPro annotationAdd BLAST	118
Domainⁱ	788 – 1014	PARP catalyticInterPro annotationAdd BLAST	227

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	429 – 456	Sequence analysisAdd BLAST		28

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1037 Eukaryota ENOG410XP18 LUCA
KEGG Orthology (KO) More...KOⁱ	K10798
OMAⁱ	WNHASCI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13H1
PhylomeDBⁱ	A0A024R3T8

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00027 BRCT, 1 hit
Gene3Dⁱ	1.20.142.10, 1 hit 2.20.140.10, 1 hit 2.20.25.630, 1 hit 3.30.1740.10, 2 hits 3.40.50.10190, 1 hit
InterProⁱ	View protein in InterPro IPR001357 BRCT_dom IPR036420 BRCT_dom_sf IPR012982 PADR1 IPR038650 PADR1_dom_sf IPR008288 PARP IPR012317 Poly(ADP-ribose)pol_cat_dom IPR004102 Poly(ADP-ribose)pol_reg_dom IPR036616 Poly(ADP-ribose)pol_reg_dom_sf IPR036930 WGR_dom_sf IPR008893 WGR_domain IPR001510 Znf_PARP IPR036957 Znf_PARP_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00533 BRCT, 1 hit PF08063 PADR1, 1 hit PF00644 PARP, 1 hit PF02877 PARP_reg, 1 hit PF05406 WGR, 1 hit PF00645 zf-PARP, 2 hits
PIRSFⁱ	PIRSF000489 NAD_ADPRT, 1 hit
SMARTⁱ	View protein in SMART SM00292 BRCT, 1 hit SM01335 PADR1, 1 hit SM00773 WGR, 1 hit SM01336 zf-PARP, 2 hits
SUPFAMⁱ	SSF142921 SSF142921, 1 hit SSF47587 SSF47587, 1 hit SSF52113 SSF52113, 1 hit
PROSITEⁱ	View protein in PROSITE PS50172 BRCT, 1 hit PS51060 PARP_ALPHA_HD, 1 hit PS51059 PARP_CATALYTIC, 1 hit PS00347 PARP_ZN_FINGER_1, 1 hit PS50064 PARP_ZN_FINGER_2, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A024R3T8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH 
        60         70         80         90        100
WYHFSCFWKV GHSIRHPDVE VDGFSELRWD DQQKVKKTAE AGGVTGKGQD 
       110        120        130        140        150
GIGSKAEKTL GDFAAEYAKS NRSTCKGCME KIEKGQVRLS KKMVDPEKPQ 
       160        170        180        190        200
LGMIDRWYHP GCFVKNREEL GFRPEYSASQ LKGFSLLATE DKEALKKQLP 
       210        220        230        240        250
GVKSEGKRKG DEVDGVDEVA KKKSKKEKDK DSKLEKALKA QNDLIWNIKD 
       260        270        280        290        300
ELKKVCSTND LKELLIFNKQ QVPSGESAIL DRVADGMVFG ALLPCEECSG 
       310        320        330        340        350
QLVFKSDAYY CTGDVTAWTK CMVKTQTPNR KEWVTPKEFR EISYLKKLKV 
       360        370        380        390        400
KKQDRIFPPE TSASVAATPP PSTASAPAAV NSSASADKPL SNMKILTLGK 
       410        420        430        440        450
LSRNKDEVKA MIEKLGGKLT GTANKASLCI STKKEVEKMN KKMEEVKEAN 
       460        470        480        490        500
IRVVSEDFLQ DVSASTKSLQ ELFLAHILSP WGAEVKAEPV EVVAPRGKSG 
       510        520        530        540        550
AALSKKSKGQ VKEEGINKSE KRMKLTLKGG AAVDPDSGLE HSAHVLEKGG 
       560        570        580        590        600
KVFSATLGLV DIVKGTNSYY KLQLLEDDKE NRYWIFRSWG RVGTVIGSNK 
       610        620        630        640        650
LEQMPSKEDA IEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE 
       660        670        680        690        700
AVKKLTVNPG TKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK 
       710        720        730        740        750
LSKRQIQAAY SILSEVQQAV SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP 
       760        770        780        790        800
LLNNADSVQA KVEMLDNLLD IEVAYSLLRG GSDDSSKDPI DVNYEKLKTD 
       810        820        830        840        850
IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE REGECQRYKP 
       860        870        880        890        900
FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM 
       910        920        930        940        950
VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG 
       960        970        980        990       1000
LGKTTPDPSA NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK 
      1010 
YLLKLKFNFK TSLW

Length:1,014

Mass (Da):113,084

Last modified:July 9, 2014 - v1

Checksum:ⁱ6A5FC01EB91C046B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471098 Genomic DNA Translation: EAW69784.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001609.2, NM_001618.3
UniGeneⁱ	Hs.177766

Genome annotation databases

GeneIDⁱ	142
KEGGⁱ	hsa:142

Protein	Similar proteins		Species	Score	Length
A0A024R3T8	Poly [ADP-ribose] polymerase 1	)	HUMAN		1014
UPI0000237CD7		HUMAN		350
UPI0001753A1F		HUMAN		126
UPI000719A093		HUMAN		214
UPI0001F7127C		HUMAN		112

Protein	Similar proteins		Species	Score	Length
A0A024R3T8	Poly [ADP-ribose] polymerase 1	)	HUMAN		1014
Poly [ADP-ribose] polymerase		FELCA		1182
UPI00090477AF		PANPR		1025
UPI00093BD9C4		great roundleaf bat		1021
UPI00044046AD		BALAS		1021
+97

Protein	Similar proteins		Species	Score	Length
A0A024R3T8	Poly [ADP-ribose] polymerase 1	)	HUMAN		1014
Poly [ADP-ribose] polymerase		FELCA		1182
UPI00090477AF		PANPR		1025
UPI00093BD9C4		great roundleaf bat		1021
UPI00044046AD		BALAS		1021
+121

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471098 Genomic DNA Translation: EAW69784.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001609.2, NM_001618.3
UniGeneⁱ	Hs.177766

3D structure databases

ProteinModelPortalⁱ	A0A024R3T8
SMRⁱ	A0A024R3T8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	A0A024R3T8

PRIDEⁱ

A0A024R3T8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	142
KEGGⁱ	hsa:142

Organism-specific databases

CTDⁱ	142
EuPathDBⁱ	HostDB:ENSG00000143799.12

Phylogenomic databases

eggNOGⁱ	KOG1037 Eukaryota ENOG410XP18 LUCA
KEGG Orthology (KO) More...KOⁱ	K10798
OMAⁱ	WNHASCI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13H1
PhylomeDBⁱ	A0A024R3T8

Miscellaneous databases

ChiTaRSⁱ	PARP1 human
GenomeRNAiⁱ	142

Gene expression databases

Bgeeⁱ	ENSG00000143799
ExpressionAtlasⁱ	A0A024R3T8 baseline and differential

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00027 BRCT, 1 hit
Gene3Dⁱ	1.20.142.10, 1 hit 2.20.140.10, 1 hit 2.20.25.630, 1 hit 3.30.1740.10, 2 hits 3.40.50.10190, 1 hit
InterProⁱ	View protein in InterPro IPR001357 BRCT_dom IPR036420 BRCT_dom_sf IPR012982 PADR1 IPR038650 PADR1_dom_sf IPR008288 PARP IPR012317 Poly(ADP-ribose)pol_cat_dom IPR004102 Poly(ADP-ribose)pol_reg_dom IPR036616 Poly(ADP-ribose)pol_reg_dom_sf IPR036930 WGR_dom_sf IPR008893 WGR_domain IPR001510 Znf_PARP IPR036957 Znf_PARP_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00533 BRCT, 1 hit PF08063 PADR1, 1 hit PF00644 PARP, 1 hit PF02877 PARP_reg, 1 hit PF05406 WGR, 1 hit PF00645 zf-PARP, 2 hits
PIRSFⁱ	PIRSF000489 NAD_ADPRT, 1 hit
SMARTⁱ	View protein in SMART SM00292 BRCT, 1 hit SM01335 PADR1, 1 hit SM00773 WGR, 1 hit SM01336 zf-PARP, 2 hits
SUPFAMⁱ	SSF142921 SSF142921, 1 hit SSF47587 SSF47587, 1 hit SSF52113 SSF52113, 1 hit
PROSITEⁱ	View protein in PROSITE PS50172 BRCT, 1 hit PS51060 PARP_ALPHA_HD, 1 hit PS51059 PARP_CATALYTIC, 1 hit PS00347 PARP_ZN_FINGER_1, 1 hit PS50064 PARP_ZN_FINGER_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A024R3T8_HUMAN
Accessionⁱ	A0A024R3T8Primary (citable) accession number: A0A024R3T8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 9, 2014
	Last sequence update:	July 9, 2014
	Last modified:	July 18, 2018
	This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0A024R3T8 (A0A024R3T8_HUMAN)

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Poly [ADP-ribose] polymerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ