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UniProtKB - A0A024R3T8 (A0A024R3T8_HUMAN)

Entry version 58 (19 Jan 2022)
Sequence version 1 (09 Jul 2014)
Previous versions | rss
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Protein

Poly [ADP-ribose] polymerase

Gene

PARP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.UniRule annotationARBA annotation EC:2.4.2.30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotationARBA annotation, GlycosyltransferaseUniRule annotationARBA annotation, Transferase
LigandMetal-binding, NADUniRule annotationARBA annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.30UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARP1Imported
ORF Names:hCG_14746Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143799

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

ADP-ribosylationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143799, Expressed in ventricular zone and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A024R3T8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		A0A024R3T8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A024R3T8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 93PARP-typeInterPro annotationAdd BLAST85
Domaini113 – 203PARP-typeInterPro annotationAdd BLAST91
Domaini385 – 461BRCTInterPro annotationAdd BLAST77
Domaini662 – 779PARP alpha-helicalInterPro annotationAdd BLAST118
Domaini788 – 1014PARP catalyticInterPro annotationAdd BLAST227

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni198 – 233DisorderedSequence analysisAdd BLAST36
Regioni361 – 385DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili429 – 456Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi366 – 385Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARTD/PARP family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004841_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		HTNIDDT

Database of Orthologous Groups

More...OrthoDBi		909382at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A0A024R3T8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.142.10, 1 hit
2.20.25.630, 1 hit
3.30.1740.10, 2 hits
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR012982, PADR1
IPR038650, PADR1_dom_sf
IPR008288, PARP
IPR012317, Poly(ADP-ribose)pol_cat_dom
IPR004102, Poly(ADP-ribose)pol_reg_dom
IPR036616, Poly(ADP-ribose)pol_reg_dom_sf
IPR036930, WGR_dom_sf
IPR008893, WGR_domain
IPR001510, Znf_PARP
IPR036957, Znf_PARP_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00533, BRCT, 1 hit
PF08063, PADR1, 1 hit
PF00644, PARP, 1 hit
PF02877, PARP_reg, 1 hit
PF05406, WGR, 1 hit
PF00645, zf-PARP, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000489, NAD_ADPRT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00292, BRCT, 1 hit
SM01335, PADR1, 1 hit
SM00773, WGR, 1 hit
SM01336, zf-PARP, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF142921, SSF142921, 1 hit
SSF47587, SSF47587, 1 hit
SSF52113, SSF52113, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50172, BRCT, 1 hit
PS51060, PARP_ALPHA_HD, 1 hit
PS51059, PARP_CATALYTIC, 1 hit
PS00347, PARP_ZN_FINGER_1, 1 hit
PS50064, PARP_ZN_FINGER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R3T8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH 
        60         70         80         90        100
WYHFSCFWKV GHSIRHPDVE VDGFSELRWD DQQKVKKTAE AGGVTGKGQD 
       110        120        130        140        150
GIGSKAEKTL GDFAAEYAKS NRSTCKGCME KIEKGQVRLS KKMVDPEKPQ 
       160        170        180        190        200
LGMIDRWYHP GCFVKNREEL GFRPEYSASQ LKGFSLLATE DKEALKKQLP 
       210        220        230        240        250
GVKSEGKRKG DEVDGVDEVA KKKSKKEKDK DSKLEKALKA QNDLIWNIKD 
       260        270        280        290        300
ELKKVCSTND LKELLIFNKQ QVPSGESAIL DRVADGMVFG ALLPCEECSG 
       310        320        330        340        350
QLVFKSDAYY CTGDVTAWTK CMVKTQTPNR KEWVTPKEFR EISYLKKLKV 
       360        370        380        390        400
KKQDRIFPPE TSASVAATPP PSTASAPAAV NSSASADKPL SNMKILTLGK 
       410        420        430        440        450
LSRNKDEVKA MIEKLGGKLT GTANKASLCI STKKEVEKMN KKMEEVKEAN 
       460        470        480        490        500
IRVVSEDFLQ DVSASTKSLQ ELFLAHILSP WGAEVKAEPV EVVAPRGKSG 
       510        520        530        540        550
AALSKKSKGQ VKEEGINKSE KRMKLTLKGG AAVDPDSGLE HSAHVLEKGG 
       560        570        580        590        600
KVFSATLGLV DIVKGTNSYY KLQLLEDDKE NRYWIFRSWG RVGTVIGSNK 
       610        620        630        640        650
LEQMPSKEDA IEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE 
       660        670        680        690        700
AVKKLTVNPG TKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK 
       710        720        730        740        750
LSKRQIQAAY SILSEVQQAV SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP 
       760        770        780        790        800
LLNNADSVQA KVEMLDNLLD IEVAYSLLRG GSDDSSKDPI DVNYEKLKTD 
       810        820        830        840        850
IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE REGECQRYKP 
       860        870        880        890        900
FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM 
       910        920        930        940        950
VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG 
       960        970        980        990       1000
LGKTTPDPSA NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK 
      1010 
YLLKLKFNFK TSLW
Length:1,014
Mass (Da):113,084
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A5FC01EB91C046B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471098 Genomic DNA Translation: EAW69784.1

NCBI Reference Sequences

More...RefSeqi		NP_001609.2, NM_001618.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		142

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:142

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000366794.10; ENSP00000355759.5; NM_001618.4; NP_001609.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471098 Genomic DNA Translation: EAW69784.1
RefSeqiNP_001609.2, NM_001618.3

3D structure databases

SMRiA0A024R3T8
ModBaseiSearch...

Chemistry databases

BindingDBiA0A024R3T8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3545, 1898 antibodies from 50 providers

The DNASU plasmid repository

More...DNASUi		142

Genome annotation databases

GeneIDi142
KEGGihsa:142
MANE-SelectiENST00000366794.10; ENSP00000355759.5; NM_001618.4; NP_001609.2

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		142
VEuPathDBiHostDB:ENSG00000143799

Phylogenomic databases

HOGENOMiCLU_004841_0_0_1
OMAiHTNIDDT
OrthoDBi909382at2759
PhylomeDBiA0A024R3T8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		142, 27 hits in 1056 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PARP1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		142

Gene expression databases

BgeeiENSG00000143799, Expressed in ventricular zone and 247 other tissues
ExpressionAtlasiA0A024R3T8, baseline and differential

Family and domain databases

Gene3Di1.20.142.10, 1 hit
2.20.25.630, 1 hit
3.30.1740.10, 2 hits
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR012982, PADR1
IPR038650, PADR1_dom_sf
IPR008288, PARP
IPR012317, Poly(ADP-ribose)pol_cat_dom
IPR004102, Poly(ADP-ribose)pol_reg_dom
IPR036616, Poly(ADP-ribose)pol_reg_dom_sf
IPR036930, WGR_dom_sf
IPR008893, WGR_domain
IPR001510, Znf_PARP
IPR036957, Znf_PARP_sf
PfamiView protein in Pfam
PF00533, BRCT, 1 hit
PF08063, PADR1, 1 hit
PF00644, PARP, 1 hit
PF02877, PARP_reg, 1 hit
PF05406, WGR, 1 hit
PF00645, zf-PARP, 2 hits
PIRSFiPIRSF000489, NAD_ADPRT, 1 hit
SMARTiView protein in SMART
SM00292, BRCT, 1 hit
SM01335, PADR1, 1 hit
SM00773, WGR, 1 hit
SM01336, zf-PARP, 2 hits
SUPFAMiSSF142921, SSF142921, 1 hit
SSF47587, SSF47587, 1 hit
SSF52113, SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172, BRCT, 1 hit
PS51060, PARP_ALPHA_HD, 1 hit
PS51059, PARP_CATALYTIC, 1 hit
PS00347, PARP_ZN_FINGER_1, 1 hit
PS50064, PARP_ZN_FINGER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R3T8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R3T8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: January 19, 2022
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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