UniProtKB - A0A024R3I5 (A0A024R3I5_HUMAN)
Protein
Submitted name:
Melanoma cell adhesion molecule, isoform CRA_a
Gene
MCAM
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Melanoma cell adhesion molecule, isoform CRA_aImported |
Gene namesi | Name:MCAMImported ORF Names:hCG_15250Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000076706.14 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Extracellular region or secreted
- extracellular space Source: Ensembl
Nucleus
- nucleus Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 560 – 583 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5014214219 | 24 – 646 | Sequence analysisAdd BLAST | 623 |
Expressioni
Gene expression databases
Bgeei | ENSG00000076706, Expressed in popliteal artery and 242 other tissues |
ExpressionAtlasi | A0A024R3I5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 129 | Ig-likeInterPro annotationAdd BLAST | 111 | |
Domaini | 139 – 242 | Ig-likeInterPro annotationAdd BLAST | 104 | |
Domaini | 244 – 321 | Ig-likeInterPro annotationAdd BLAST | 78 | |
Domaini | 335 – 424 | Ig-likeInterPro annotationAdd BLAST | 90 | |
Domaini | 430 – 510 | Ig-likeInterPro annotationAdd BLAST | 81 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 278 – 299 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 525 – 554 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 620 – 646 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 525 – 546 | PolarSequence analysisAdd BLAST | 22 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_028888_3_0_1 |
OMAi | NPQPHFS |
OrthoDBi | 864786at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF00047, ig, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits |
i Sequence
Sequence statusi: Complete.
A0A024R3I5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLPRLVCAF LLAACCCCPR VAGVPGEAEQ PAPELVEVEV GSTALLKCGL
60 70 80 90 100
SQSQGNLSHV DWFSVHKEKR TLIFRVRQGQ GQSEPGEYEQ RLSLQDRGAT
110 120 130 140 150
LALTQVTPQD ERIFLCQGKR PRSQEYRIQL RVYKAPEEPN IQVNPLGIPV
160 170 180 190 200
NSKEPEEVAT CVGRNGYPIP QVIWYKNGRP LKEEKNRVHI QSSQTVESSG
210 220 230 240 250
LYTLQSILKA QLVKEDKDAQ FYCELNYRLP SGNHMKESRE VTVPVFYPTE
260 270 280 290 300
KVWLEVEPVG MLKEGDRVEI RCLADGNPPP HFSISKQNPS TREAEEETTN
310 320 330 340 350
DNGVLVLEPA RKEHSGRYEC QGLDLDTMIS LLSEPQELLV NYVSDVRVSP
360 370 380 390 400
AAPERQEGSS LTLTCEAESS QDLEFQWLRE ETGQVLERGP VLQLHDLKRE
410 420 430 440 450
AGGGYRCVAS VPSIPGLNRT QLVNVAIFGP PWMAFKERKV WVKENMVLNL
460 470 480 490 500
SCEASGHPRP TISWNVNGTA SEQDQDPQRV LSTLNVLVTP ELLETGVECT
510 520 530 540 550
ASNDLGKNTS ILFLELVNLT TLTPDSNTTT GLSTSTASPH TRANSTSTER
560 570 580 590 600
KLPEPESRGV VIVAVIVCIL VLAVLGAVLY FLYKKGKLPC RRSGKQEITL
610 620 630 640
PPSRKSELVV EVKSDKLPEE MGLLQGSSGD KRAPGDQGEK YIDLRH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471065 Genomic DNA Translation: EAW67477.1 CH471065 Genomic DNA Translation: EAW67478.1 |
RefSeqi | NP_006491.2, NM_006500.2 |
Genome annotation databases
GeneIDi | 4162 |
KEGGi | hsa:4162 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471065 Genomic DNA Translation: EAW67477.1 CH471065 Genomic DNA Translation: EAW67478.1 |
RefSeqi | NP_006491.2, NM_006500.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 2244, 1982 antibodies |
Genome annotation databases
GeneIDi | 4162 |
KEGGi | hsa:4162 |
Organism-specific databases
CTDi | 4162 |
VEuPathDBi | HostDB:ENSG00000076706.14 |
Phylogenomic databases
HOGENOMi | CLU_028888_3_0_1 |
OMAi | NPQPHFS |
OrthoDBi | 864786at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4162, 4 hits in 880 CRISPR screens |
ChiTaRSi | MCAM, human |
GenomeRNAii | 4162 |
Gene expression databases
Bgeei | ENSG00000076706, Expressed in popliteal artery and 242 other tissues |
ExpressionAtlasi | A0A024R3I5, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF00047, ig, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R3I5_HUMAN | |
Accessioni | A0A024R3I5Primary (citable) accession number: A0A024R3I5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |