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Protein

Interleukin-18

Gene

IL18

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18UniRule annotation
Short name:
IL-18UniRule annotation
Gene namesi
Name:IL18Imported
ORF Names:hCG_39294Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000150782.11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiA0A024R3E0

Expressioni

Gene expression databases

BgeeiENSG00000150782 Expressed in 194 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiA0A024R3E0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A024R3E0
SMRiA0A024R3E0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410J3U9 Eukaryota
ENOG410ZGS8 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR015529 IL-18
IPR000975 IL-1_fam
IPR008996 IL1/FGF
PANTHERiPTHR45200 PTHR45200, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PIRSFiPIRSF015162 Interleukin_18, 1 hit
PRINTSiPR01933 INTRLEUKIN18
SUPFAMiSSF50353 SSF50353, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024R3E0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEPVEDNC INFVAMKFID NTLYFIENLE SDYFGKLESK LSVIRNLNDQ
60 70 80 90 100
VLFIDQGNRP LFEDMTDSDC RDNAPRTIFI ISMYKDSQPR GMAVTISVKC
110 120 130 140 150
EKISTLSCEN KIISFKEMNP PDNIKDTKSD IIFFQRSVPG HDNKMQFESS
160 170 180
SYEGYFLACE KERDLFKLIL KKEDELGDRS IMFTVQNED
Length:189
Mass (Da):21,896
Last modified:July 9, 2014 - v1
Checksum:iA8BA275CF713A4B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471065 Genomic DNA Translation: EAW67185.1
RefSeqiNP_001230140.1, NM_001243211.1
XP_011541107.1, XM_011542805.1
UniGeneiHs.83077

Genome annotation databases

GeneIDi3606

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471065 Genomic DNA Translation: EAW67185.1
RefSeqiNP_001230140.1, NM_001243211.1
XP_011541107.1, XM_011542805.1
UniGeneiHs.83077

3D structure databases

ProteinModelPortaliA0A024R3E0
SMRiA0A024R3E0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA0A024R3E0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3606

Organism-specific databases

CTDi3606
EuPathDBiHostDB:ENSG00000150782.11

Phylogenomic databases

eggNOGiENOG410J3U9 Eukaryota
ENOG410ZGS8 LUCA

Miscellaneous databases

GenomeRNAii3606

Gene expression databases

BgeeiENSG00000150782 Expressed in 194 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiA0A024R3E0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR015529 IL-18
IPR000975 IL-1_fam
IPR008996 IL1/FGF
PANTHERiPTHR45200 PTHR45200, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PIRSFiPIRSF015162 Interleukin_18, 1 hit
PRINTSiPR01933 INTRLEUKIN18
SUPFAMiSSF50353 SSF50353, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R3E0_HUMAN
AccessioniPrimary (citable) accession number: A0A024R3E0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 12, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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