UniProtKB - A0A024R3C6 (A0A024R3C6_HUMAN)
Protein
Submitted name:
Zinc finger and BTB domain containing 16 isoform 1
Gene
ZBTB16
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: Ensembl
- double-stranded DNA binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein domain specific binding Source: Ensembl
GO - Biological processi
- anterior/posterior pattern specification Source: Ensembl
- central nervous system development Source: Ensembl
- embryonic digit morphogenesis Source: Ensembl
- embryonic hindlimb morphogenesis Source: Ensembl
- embryonic pattern specification Source: Ensembl
- forelimb morphogenesis Source: Ensembl
- hemopoiesis Source: Ensembl
- male germ-line stem cell asymmetric division Source: Ensembl
- mesonephros development Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of myeloid cell differentiation Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of NK T cell differentiation Source: Ensembl
- protein localization to nucleus Source: Ensembl
- skeletal system development Source: Ensembl
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger and BTB domain containing 16 isoform 1ImportedSubmitted name: Zinc finger and BTB domain containing 16, isoform CRA_aImported |
Gene namesi | Name:ZBTB16Imported ORF Names:hCG_38015Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000109906.13 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000109906, Expressed in upper lobe of lung and 235 other tissues |
Interactioni
GO - Molecular functioni
- protein C-terminus binding Source: Ensembl
- protein domain specific binding Source: Ensembl
Chemistry databases
BindingDBi | A0A024R3C6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 96 | BTBInterPro annotationAdd BLAST | 63 | |
Domaini | 404 – 431 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 432 – 459 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 461 – 488 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 490 – 517 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 518 – 545 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 546 – 573 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 574 – 601 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 602 – 629 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 630 – 657 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 215 – 236 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 249 – 332 | DisorderedSequence analysisAdd BLAST | 84 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
HOGENOMi | CLU_026420_0_0_1 |
OMAi | MGLIQLQ |
OrthoDBi | 1318335at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
i Sequence
Sequence statusi: Complete.
A0A024R3C6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT
60 70 80 90 100
VLACTSKMFE ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD
110 120 130 140 150
DLLYAAEILE IEYLEEQCLK MLETIQASDD NDTEATMADG GAEEEEDRKA
160 170 180 190 200
RYLKNIFISK HSSEESGYAS VAGQSLPGPM VDQSPSVSTS FGLSAMSPTK
210 220 230 240 250
AAVDSLMTIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE VKTEMMQVDE
260 270 280 290 300
VPSQDSPGAA ESSISGGMGD KVEERGKEGP GTPTRSSVIT SARELHYGRE
310 320 330 340 350
ESAEQVPPPA EAGQAPTGRP EHPAPPPEKH LGIYSVLPNH KADAVLSMPS
360 370 380 390 400
SVTSGLHVQP ALAVSMDFST YGGLLPQGFI QRELFSKLGE LAVGMKSESR
410 420 430 440 450
TIGEQCSVCG VELPDNEAVE QHRKLHSGMK TYGCELCGKR FLDSLRLRMH
460 470 480 490 500
LLAHSAGAKA FVCDQCGAQF SKEDALETHR QTHTGTDMAV FCLLCGKRFQ
510 520 530 540 550
AQSALQQHME VHAGVRSYIC SECNRTFPSH TALKRHLRSH TGDHPYECEF
560 570 580 590 600
CGSCFRDEST LKSHKRIHTG EKPYECNGCG KKFSLKHQLE THYRVHTGEK
610 620 630 640 650
PFECKLCHQR SRDYSAMIKH LRTHNGASPY QCTICTEYCP SLSSMQKHMK
660 670
GHKPEEIPPD WRIEKTYLYL CYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178400 mRNA Translation: ALQ33858.1 CH471065 Genomic DNA Translation: EAW67241.1 CH471065 Genomic DNA Translation: EAW67242.1 |
RefSeqi | NP_001018011.1, NM_001018011.1 NP_005997.2, NM_006006.4 XP_016873746.1, XM_017018257.1 XP_016873747.1, XM_017018258.1 XP_016873748.1, XM_017018259.1 |
Genome annotation databases
GeneIDi | 7704 |
KEGGi | hsa:7704 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178400 mRNA Translation: ALQ33858.1 CH471065 Genomic DNA Translation: EAW67241.1 CH471065 Genomic DNA Translation: EAW67242.1 |
RefSeqi | NP_001018011.1, NM_001018011.1 NP_005997.2, NM_006006.4 XP_016873746.1, XM_017018257.1 XP_016873747.1, XM_017018258.1 XP_016873748.1, XM_017018259.1 |
3D structure databases
SMRi | A0A024R3C6 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024R3C6 |
Protocols and materials databases
Antibodypediai | 897, 374 antibodies |
Genome annotation databases
GeneIDi | 7704 |
KEGGi | hsa:7704 |
Organism-specific databases
CTDi | 7704 |
EuPathDBi | HostDB:ENSG00000109906.13 |
Phylogenomic databases
HOGENOMi | CLU_026420_0_0_1 |
OMAi | MGLIQLQ |
OrthoDBi | 1318335at2759 |
Miscellaneous databases
BioGRID-ORCSi | 7704, 3 hits in 866 CRISPR screens |
ChiTaRSi | ZBTB16, human |
GenomeRNAii | 7704 |
Gene expression databases
Bgeei | ENSG00000109906, Expressed in upper lobe of lung and 235 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R3C6_HUMAN | |
Accessioni | A0A024R3C6Primary (citable) accession number: A0A024R3C6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |