UniProtKB - A0A024R3C5 (A0A024R3C5_HUMAN)
Protein
D(2) dopamine receptor
Gene
DRD2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- dopamine neurotransmitter receptor activity Source: InterPro
- G protein-coupled receptor activity Source: UniProtKB-KW
GO - Biological processi
- adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: D(2) dopamine receptorARBA annotationAlternative name(s): Dopamine D2 receptorARBA annotation |
Gene namesi | Name:DRD2Imported ORF Names:hCG_39593Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000149295.13 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- synapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 36 – 59 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 71 – 93 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 109 – 131 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 152 – 172 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 192 – 216 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 374 – 395 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 407 – 429 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000149295, Expressed in adenohypophysis and 134 other tissues |
ExpressionAtlasi | A0A024R3C5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 426 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 376 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 281 – 332 | DisorderedSequence analysisAdd BLAST | 52 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
OrthoDBi | 384993at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001922, Dopamine_D2_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00567, DOPAMINED2R PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R3C5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF
60 70 80 90 100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW
110 120 130 140 150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR
160 170 180 190 200
RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV
210 220 230 240 250
PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM
260 270 280 290 300
KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP
310 320 330 340 350
SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK
360 370 380 390 400
TRTSLKTMSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD
410 420 430 440
CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471065 Genomic DNA Translation: EAW67221.1 CH471065 Genomic DNA Translation: EAW67222.1 |
RefSeqi | NP_000786.1, NM_000795.3 XP_016872785.1, XM_017017296.1 |
Genome annotation databases
GeneIDi | 1813 |
KEGGi | hsa:1813 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471065 Genomic DNA Translation: EAW67221.1 CH471065 Genomic DNA Translation: EAW67222.1 |
RefSeqi | NP_000786.1, NM_000795.3 XP_016872785.1, XM_017017296.1 |
3D structure databases
SMRi | A0A024R3C5 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024R3C5 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 2801, 360 antibodies |
Genome annotation databases
GeneIDi | 1813 |
KEGGi | hsa:1813 |
Organism-specific databases
CTDi | 1813 |
VEuPathDBi | HostDB:ENSG00000149295.13 |
Phylogenomic databases
OrthoDBi | 384993at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1813, 5 hits in 880 CRISPR screens |
ChiTaRSi | DRD2, human |
GenomeRNAii | 1813 |
Gene expression databases
Bgeei | ENSG00000149295, Expressed in adenohypophysis and 134 other tissues |
ExpressionAtlasi | A0A024R3C5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001922, Dopamine_D2_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00567, DOPAMINED2R PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R3C5_HUMAN | |
Accessioni | A0A024R3C5Primary (citable) accession number: A0A024R3C5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |