Dopamine receptor D2, isoform CRA_c

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dopamine binding Source: Ensembl
• dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: Ensembl
• ionotropic glutamate receptor binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• protein homodimerization activity Source: Ensembl

GO - Biological processⁱ

• G protein-coupled receptor internalization Source: Ensembl
• Wnt signaling pathway Source: Ensembl
• acid secretion Source: Ensembl
• activation of protein kinase activity Source: Ensembl
• adenohypophysis development Source: Ensembl
• adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
• adult walking behavior Source: Ensembl
• auditory behavior Source: Ensembl
• autophagy Source: Ensembl
• axonogenesis Source: Ensembl
• behavioral response to cocaine Source: Ensembl
• behavioral response to ethanol Source: Ensembl
• branching morphogenesis of a nerve Source: Ensembl
• cerebral cortex GABAergic interneuron migration Source: Ensembl
• circadian regulation of gene expression Source: Ensembl
• dopamine metabolic process Source: Ensembl
• drinking behavior Source: Ensembl
• grooming behavior Source: Ensembl
• long-term memory Source: Ensembl
• negative regulation of blood pressure Source: Ensembl
• negative regulation of cell death Source: Ensembl
• negative regulation of cell migration Source: Ensembl
• negative regulation of cell population proliferation Source: Ensembl
• negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
• negative regulation of cytosolic calcium ion concentration Source: Ensembl
• negative regulation of dopamine receptor signaling pathway Source: Ensembl
• negative regulation of dopamine secretion Source: Ensembl
• negative regulation of innate immune response Source: Ensembl
• negative regulation of insulin secretion Source: Ensembl
• negative regulation of protein kinase B signaling Source: Ensembl
• negative regulation of protein phosphorylation Source: Ensembl
• negative regulation of synaptic transmission, glutamatergic Source: Ensembl
• negative regulation of voltage-gated calcium channel activity Source: Ensembl
• nervous system process involved in regulation of systemic arterial blood pressure Source: Ensembl
• neuron-neuron synaptic transmission Source: Ensembl
• orbitofrontal cortex development Source: Ensembl
• peristalsis Source: Ensembl
• phospholipase C-activating dopamine receptor signaling pathway Source: Ensembl
• pigmentation Source: Ensembl
• positive regulation of ERK1 and ERK2 cascade Source: Ensembl
• positive regulation of G protein-coupled receptor signaling pathway Source: Ensembl
• positive regulation of dopamine uptake involved in synaptic transmission Source: Ensembl
• positive regulation of growth hormone secretion Source: Ensembl
• positive regulation of long-term synaptic potentiation Source: Ensembl
• positive regulation of multicellular organism growth Source: Ensembl
• positive regulation of neuroblast proliferation Source: Ensembl
• positive regulation of receptor internalization Source: Ensembl
• positive regulation of renal sodium excretion Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of urine volume Source: Ensembl
• postsynaptic modulation of chemical synaptic transmission Source: Ensembl
• prepulse inhibition Source: Ensembl
• protein localization Source: Ensembl
• regulation of heart rate Source: Ensembl
• regulation of locomotion involved in locomotory behavior Source: Ensembl
• regulation of long-term neuronal synaptic plasticity Source: Ensembl
• regulation of phosphoprotein phosphatase activity Source: Ensembl
• regulation of potassium ion transport Source: Ensembl
• regulation of sodium ion transport Source: Ensembl
• regulation of synapse structural plasticity Source: Ensembl
• regulation of synaptic transmission, GABAergic Source: Ensembl
• regulation of synaptic vesicle exocytosis Source: Ensembl
• response to amphetamine Source: Ensembl
• response to axon injury Source: Ensembl
• response to hypoxia Source: Ensembl
• response to inactivity Source: Ensembl
• response to iron ion Source: Ensembl
• response to morphine Source: Ensembl
• response to nicotine Source: Ensembl
• sensory perception of smell Source: Ensembl
• striatum development Source: Ensembl
• synapse assembly Source: Ensembl
• synaptic transmission, dopaminergic Source: Ensembl
• temperature homeostasis Source: Ensembl
• visual learning Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• ionotropic glutamate receptor binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• protein homodimerization activity Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM 
       260        270        280        290        300
KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP 
       310        320        330        340        350
SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK 
       360        370        380        390        400
TRTSLKTMSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD 
       410        420        430        440 
CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC        

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ