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Entry version 38 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

KIAA0863 protein, isoform CRA_a

Gene

KIAA0863

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
Biological processTranscription, Transcription regulationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
KIAA0863 protein, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIAA0863Imported
ORF Names:hCG_15188Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101544.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    NucleusARBA annotation

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    A0A024R377

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000101544, Expressed in female gonad and 237 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    A0A024R377, baseline and differential

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    A0A024R377

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini770 – 798C2H2-typeInterPro annotationAdd BLAST29

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni274 – 329DisorderedSequence analysisAdd BLAST56

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi300 – 329PolarSequence analysisAdd BLAST30

    Keywords - Domaini

    HomeoboxARBA annotation, Zinc-fingerPROSITE-ProRule annotation

    Phylogenomic databases

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_009119_1_0_1

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PDKYYCK

    Database of Orthologous Groups

    More...
    OrthoDBi
    135860at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    A0A024R377

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00086, homeodomain, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR038861, ADNP/ADNP2
    IPR009057, Homeobox-like_sf
    IPR001356, Homeobox_dom
    IPR013087, Znf_C2H2_type

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR15740, PTHR15740, 2 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00389, HOX, 1 hit
    SM00355, ZnF_C2H2, 8 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF46689, SSF46689, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00028, ZINC_FINGER_C2H2_1, 1 hit
    PS50157, ZINC_FINGER_C2H2_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A024R377-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MFQIPVENLD NIRKVRKKVK GILVDIGLDS CKELLKDLKG FDPGEKYFHN
    60 70 80 90 100
    TSWGDVSLWE PSGKKVRYRT KPYCCGLCKY STKVLTSFKN HLHRYHEDEI
    110 120 130 140 150
    DQELVIPCPN CVFASQPKVV GRHFRMFHAP VRKVQNYTVN ILGETKSSRS
    160 170 180 190 200
    DVISFTCLKC NFSNTLYYSM KKHVLVAHFH YLINSYFGLR TEEMGEQPKT
    210 220 230 240 250
    NDTVSIEKIP PPDKYYCKKC NANASSQDAL MYHILTSDIH RDLENKLRSV
    260 270 280 290 300
    ISEHIKRTGL LKQTHIAPKP AAHLAAPANG SAPSAPAQPP CFHLALPQNS
    310 320 330 340 350
    PSPAAGQPVT VAQGAPGSLT HSPPAAGQSH MTLVSSPLPV GQNSLTLQPP
    360 370 380 390 400
    APQPVFLSHG VPLHQSVNPP VLPLSQPVGP VNKSVGTSVL PINQTVRPGV
    410 420 430 440 450
    LPLTQPVGPI NRPVGPGVLP VSPSVTPGVL QAVSPGVLSV SRAVPSGVLP
    460 470 480 490 500
    AGQMTPAGQM TPAGVIPGQT ATSGVLPTGQ MVQSGVLPVG QTAPSRVLPP
    510 520 530 540 550
    GQTAPLRVIS AGQVVPSGLL SPNQTVSSSA VVPVNQGVNS GVLQLSQPVV
    560 570 580 590 600
    SGVLPVGQPV RPGVLQLNQT VGTNILPVNQ PVRPGASQNT TFLTSGSILR
    610 620 630 640 650
    QLIPTGKQVN GIPTYTLAPV SVTLPVPPGG LATVAPPQMP IQLLPSGAAA
    660 670 680 690 700
    PMAGSMPGMP SPPVLVNAAQ SVFVQASSSA ADTNQVLKQA KQWKTCPVCN
    710 720 730 740 750
    ELFPSNVYQV HMEVAHKHSE SKSGEKLEPE KLAACAPFLK WMREKTVRCL
    760 770 780 790 800
    SCKCLVSEEE LIHHLLMHGL GCLFCPCTFH DIKGLSEHSR NRHLGKKKLP
    810 820 830 840 850
    MDYSNRGFQL DVDANGNLLF PHLDFITILP KEKLGEREVY LAILAGIHSK
    860 870 880 890 900
    SLVPVYVKVR PQAEGTPGST GKRVSTCPFC FGPFVTTEAY ELHLKERHHI
    910 920 930 940 950
    MPTVHTVLKS PAFKCIHCCG VYTGNMTLAA IAVHLVRCRS APKDSSSDLQ
    960 970 980 990 1000
    AQPGFIHNSE LLLVSGEVMH DSSFSVKRKL PDGHLGAEDQ RHGEEQPPIL
    1010 1020 1030 1040 1050
    NADAAPGPEK VTSVVPFKRQ RNESRTEGPI VKDEALQILA LDPKKYEGRS
    1060 1070 1080 1090 1100
    YEEKKQFLKD YFHKKPYPSK KEIELLSSLF WVWKIDVASF FGKRRYICMK
    1110 1120 1130
    AIKNHKPSVL LGFDMSELKN VKHRLNFEYE P
    Length:1,131
    Mass (Da):122,833
    Last modified:July 9, 2014 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73BCB3F755E6906D
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CH471117 Genomic DNA Translation: EAW66647.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_055728.1, NM_014913.3
    XP_005266713.1, XM_005266656.4

    Genome annotation databases

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    22850

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:22850

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CH471117 Genomic DNA Translation: EAW66647.1
    RefSeqiNP_055728.1, NM_014913.3
    XP_005266713.1, XM_005266656.4

    3D structure databases

    SMRiA0A024R377
    ModBaseiSearch...

    Proteomic databases

    PRIDEiA0A024R377

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    1760, 63 antibodies

    Genome annotation databases

    GeneIDi22850
    KEGGihsa:22850

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    22850
    EuPathDBiHostDB:ENSG00000101544.8

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    Phylogenomic databases

    HOGENOMiCLU_009119_1_0_1
    OMAiPDKYYCK
    OrthoDBi135860at2759
    PhylomeDBiA0A024R377

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    22850, 5 hits in 870 CRISPR screens

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    22850

    Gene expression databases

    BgeeiENSG00000101544, Expressed in female gonad and 237 other tissues
    ExpressionAtlasiA0A024R377, baseline and differential

    Family and domain databases

    CDDicd00086, homeodomain, 1 hit
    InterProiView protein in InterPro
    IPR038861, ADNP/ADNP2
    IPR009057, Homeobox-like_sf
    IPR001356, Homeobox_dom
    IPR013087, Znf_C2H2_type
    PANTHERiPTHR15740, PTHR15740, 2 hits
    SMARTiView protein in SMART
    SM00389, HOX, 1 hit
    SM00355, ZnF_C2H2, 8 hits
    SUPFAMiSSF46689, SSF46689, 1 hit
    PROSITEiView protein in PROSITE
    PS00028, ZINC_FINGER_C2H2_1, 1 hit
    PS50157, ZINC_FINGER_C2H2_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R377_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R377
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
    Last sequence update: July 9, 2014
    Last modified: August 12, 2020
    This is version 38 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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