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UniProtKB - A0A024R374 (A0A024R374_HUMAN)
Protein
Cathepsin B
Gene
CTSB
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.ARBA annotation EC:3.4.22.1
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: UniProtKB-EC
GO - Biological processi
- decidualization Source: Ensembl
- proteolysis involved in cellular protein catabolic process Source: Ensembl
- regulation of catalytic activity Source: InterPro
- thyroid hormone generation Source: Ensembl
- viral entry into host cell Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Protein family/group databases
MEROPSi | C01.060 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CTSBImported ORF Names:hCG_1990887Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000164733 |
Subcellular locationi
Lysosome
- Lysosome ARBA annotation
Plasma membrane
- Apical cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Extracellular side ARBA annotation
Extracellular region or secreted
- extracellular space Source: Ensembl
Lysosome
- lysosome Source: UniProtKB-SubCell
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- external side of plasma membrane Source: Ensembl
Keywords - Cellular componenti
LysosomeARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5014202967 | 18 – 339 | Cathepsin BSequence analysisAdd BLAST | 322 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164733, Expressed in stromal cell of endometrium and 243 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 80 – 329 | Pept_C1InterPro annotationAdd BLAST | 250 |
Sequence similaritiesi
Belongs to the peptidase C1 family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_012184_3_3_1 |
OMAi | WTVGRNF |
OrthoDBi | 865289at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR012599, Propeptide_C1A |
Pfami | View protein in Pfam PF00112, Peptidase_C1, 1 hit PF08127, Propeptide_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R374-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV
60 70 80 90 100
DMSYLKRLCG TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR
110 120 130 140 150
DQGSCGSCWA FGAVEAISDR ICIHTNAHVS VEVSAEDLLT CCGSMCGDGC
160 170 180 190 200
NGGYPAEAWN FWTRKGLVSG GLYESHVGCR PYSIPPCEHH VNGSRPPCTG
210 220 230 240 250
EGDTPKCSKI CEPGYSPTYK QDKHYGYNSY SVSNSEKDIM AEIYKNGPVE
260 270 280 290 300
GAFSVYSDFL LYKSGVYQHV TGEMMGGHAI RILGWGVENG TPYWLVANSW
310 320 330
NTDWGDNGFF KILRGQDHCG IESEVVAGIP RTDQYWEKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ891351 mRNA Translation: ADO22213.1 CH471157 Genomic DNA Translation: EAW65632.1 CH471157 Genomic DNA Translation: EAW65633.1 CH471157 Genomic DNA Translation: EAW65634.1 CH471157 Genomic DNA Translation: EAW65635.1 CH471157 Genomic DNA Translation: EAW65636.1 |
RefSeqi | NP_001899.1, NM_001908.4 NP_680090.1, NM_147780.3 NP_680091.1, NM_147781.3 NP_680092.1, NM_147782.3 NP_680093.1, NM_147783.3 XP_006716307.1, XM_006716244.2 XP_006716308.1, XM_006716245.2 XP_011542114.1, XM_011543812.2 XP_016868586.1, XM_017013097.1 XP_016868587.1, XM_017013098.1 XP_016868588.1, XM_017013099.1 XP_016868589.1, XM_017013100.1 |
Genome annotation databases
GeneIDi | 1508 |
KEGGi | hsa:1508 |
MANE-Selecti | ENST00000353047.11; ENSP00000345672.5; NM_001908.5; NP_001899.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ891351 mRNA Translation: ADO22213.1 CH471157 Genomic DNA Translation: EAW65632.1 CH471157 Genomic DNA Translation: EAW65633.1 CH471157 Genomic DNA Translation: EAW65634.1 CH471157 Genomic DNA Translation: EAW65635.1 CH471157 Genomic DNA Translation: EAW65636.1 |
RefSeqi | NP_001899.1, NM_001908.4 NP_680090.1, NM_147780.3 NP_680091.1, NM_147781.3 NP_680092.1, NM_147782.3 NP_680093.1, NM_147783.3 XP_006716307.1, XM_006716244.2 XP_006716308.1, XM_006716245.2 XP_011542114.1, XM_011543812.2 XP_016868586.1, XM_017013097.1 XP_016868587.1, XM_017013098.1 XP_016868588.1, XM_017013099.1 XP_016868589.1, XM_017013100.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | C01.060 |
Protocols and materials databases
Antibodypediai | 4373, 689 antibodies from 42 providers |
DNASUi | 1508 |
Genome annotation databases
GeneIDi | 1508 |
KEGGi | hsa:1508 |
MANE-Selecti | ENST00000353047.11; ENSP00000345672.5; NM_001908.5; NP_001899.1 |
Organism-specific databases
CTDi | 1508 |
VEuPathDBi | HostDB:ENSG00000164733 |
Phylogenomic databases
HOGENOMi | CLU_012184_3_3_1 |
OMAi | WTVGRNF |
OrthoDBi | 865289at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1508, 10 hits in 1063 CRISPR screens |
ChiTaRSi | CTSB, human |
GenomeRNAii | 1508 |
Gene expression databases
Bgeei | ENSG00000164733, Expressed in stromal cell of endometrium and 243 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR012599, Propeptide_C1A |
Pfami | View protein in Pfam PF00112, Peptidase_C1, 1 hit PF08127, Propeptide_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R374_HUMAN | |
Accessioni | A0A024R374Primary (citable) accession number: A0A024R374 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | January 19, 2022 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |