UniProtKB - A0A024R372 (A0A024R372_HUMAN)
Protein
Submitted name:
Non imprinted in Prader-Willi/Angelman syndrome 2, isoform CRA_a
Gene
NIPA2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Non imprinted in Prader-Willi/Angelman syndrome 2, isoform CRA_aImported |
Gene namesi | Name:NIPA2Imported ORF Names:hCG_1735857Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000140157.14 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endosome
- early endosome Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 30 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 57 – 79 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 85 – 104 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 111 – 130 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 150 – 171 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 178 – 203 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 215 – 235 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 247 – 268 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 280 – 299 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000140157, Expressed in colonic mucosa and 236 other tissues |
ExpressionAtlasi | A0A024R372, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the NIPA family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_012349_1_1_1 |
OMAi | KNPLAWI |
OrthoDBi | 754939at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR008521, Mg_trans_NIPA |
PANTHERi | PTHR12570, PTHR12570, 1 hit |
Pfami | View protein in Pfam PF05653, Mg_trans_NIPA, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R372-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG
60 70 80 90 100
HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS
110 120 130 140 150
SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG
160 170 180 190 200
FVVFATLVVI VALILIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG
210 220 230 240 250
IAIKELFAGK PVLRHPLAWI LLLSLIVCVS TQINYLNRAL DIFNTSIVTP
260 270 280 290 300
IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK
310 320 330 340 350
DVSFSLASLP VSFRKDEKAM NGNLSNMYEV LNNNEESLTC GIEQHTGENV
360
SRRNGNLTAF
Sequence databases
Genome annotation databases
GeneIDi | 81614 |
KEGGi | hsa:81614 |
Similar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 22214, 39 antibodies |
Genome annotation databases
GeneIDi | 81614 |
KEGGi | hsa:81614 |
Organism-specific databases
CTDi | 81614 |
VEuPathDBi | HostDB:ENSG00000140157.14 |
Phylogenomic databases
HOGENOMi | CLU_012349_1_1_1 |
OMAi | KNPLAWI |
OrthoDBi | 754939at2759 |
Miscellaneous databases
BioGRID-ORCSi | 81614, 8 hits in 872 CRISPR screens |
ChiTaRSi | NIPA2, human |
GenomeRNAii | 81614 |
Gene expression databases
Bgeei | ENSG00000140157, Expressed in colonic mucosa and 236 other tissues |
ExpressionAtlasi | A0A024R372, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR008521, Mg_trans_NIPA |
PANTHERi | PTHR12570, PTHR12570, 1 hit |
Pfami | View protein in Pfam PF05653, Mg_trans_NIPA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R372_HUMAN | |
Accessioni | A0A024R372Primary (citable) accession number: A0A024R372 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |