UniProtKB - A0A024R2K1 (A0A024R2K1_HUMAN)
Protein
Submitted name:
RAB5A, member RAS oncogene family, isoform CRA_a
Gene
RAB5A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- GTPase activity Source: Ensembl
- GTP binding Source: InterPro
GO - Biological processi
- endocytosis Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: RAB5A, member RAS oncogene family, isoform CRA_aImported |
Gene namesi | Name:RAB5AImported ORF Names:hCG_1776267Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000144566.10 |
Subcellular locationi
Cytoskeleton
- actin cytoskeleton Source: Ensembl
Endosome
- early endosome Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- early phagosome Source: Ensembl
- membrane raft Source: Ensembl
- ruffle Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000144566, Expressed in substantia nigra and 248 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 181 – 215 | DisorderedSequence analysisAdd BLAST | 35 |
Phylogenomic databases
OMAi | GKDACNC |
OrthoDBi | 1340129at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R2K1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE
60 70 80 90 100
STIGAAFLTQ TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY
110 120 130 140 150
DITNEESFAR AKNWVKELQR QASPNIVIAL SGNKADLANK RAVDFQEAQS
160 170 180 190 200
YADDNSLLFM ETSAKTSMNV NEIFMAIAKK LPKNEPQNPG ANSARGRGVD
210
LTEPTQPTRN QCCSN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471055 Genomic DNA Translation: EAW64302.1 CH471055 Genomic DNA Translation: EAW64303.1 |
RefSeqi | NP_004153.2, NM_004162.4 |
Genome annotation databases
GeneIDi | 5868 |
KEGGi | hsa:5868 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471055 Genomic DNA Translation: EAW64302.1 CH471055 Genomic DNA Translation: EAW64303.1 |
RefSeqi | NP_004153.2, NM_004162.4 |
3D structure databases
SMRi | A0A024R2K1 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 3882, 725 antibodies |
Genome annotation databases
GeneIDi | 5868 |
KEGGi | hsa:5868 |
Organism-specific databases
CTDi | 5868 |
EuPathDBi | HostDB:ENSG00000144566.10 |
Phylogenomic databases
OMAi | GKDACNC |
OrthoDBi | 1340129at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5868, 21 hits in 846 CRISPR screens |
ChiTaRSi | RAB5A, human |
GenomeRNAii | 5868 |
Gene expression databases
Bgeei | ENSG00000144566, Expressed in substantia nigra and 248 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R2K1_HUMAN | |
Accessioni | A0A024R2K1Primary (citable) accession number: A0A024R2K1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |