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UniProtKB - A0A024R2I8 (A0A024R2I8_HUMAN)
Protein
Submitted name:
Thyroid hormone nuclear receptor beta variant 1
Gene
THRB
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- chromatin DNA binding Source: Ensembl
- nuclear receptor activity Source: Ensembl
- sequence-specific DNA binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- female courtship behavior Source: Ensembl
- negative regulation of female receptivity Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of heart contraction Source: Ensembl
- retinal cone cell apoptotic process Source: Ensembl
- retinal cone cell development Source: Ensembl
- sensory perception of sound Source: Ensembl
- type I pneumocyte differentiation Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Thyroid hormone nuclear receptor beta variant 1ImportedSubmitted name: Thyroid hormone receptor, beta (Erythroblastic leukemia viral (V-erb-a) oncogene homolog 2, avian), isoform CRA_aImported |
Gene namesi | Name:THRBImported Synonyms:NR1A2Imported ORF Names:hCG_15525Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000151090 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleoplasm Source: UniProt
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000151090, Expressed in Brodmann (1909) area 23 and 212 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 104 – 181 | Nuclear receptorInterPro annotationAdd BLAST | 78 | |
Domaini | 217 – 461 | NR LBDInterPro annotationAdd BLAST | 245 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_007368_18_2_1 |
OMAi | EDCGQAS |
OrthoDBi | 1112927at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001728, ThyrH_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00546, THYROIDHORMR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R2I8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPNSMTENG LTAWDKPKHC PDREHDWKLV GMSEACLHRK SHSERRSTLK
60 70 80 90 100
NEQSSPHLIQ TTWTSSIFHL DHDDVNDQSV SSAQTFQTEE KKCKGYIPSY
110 120 130 140 150
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKNLH PSYSCKYEGK
160 170 180 190 200
CVIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR
210 220 230 240 250
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI
260 270 280 290 300
GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED
310 320 330 340 350
QIILLKGCCM EIMSLRAAVR YDPESETLTL NGEMAVTRGQ LKNGGLGVVS
360 370 380 390 400
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL
410 420 430 440 450
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL
460
FPPLFLEVFE D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692825 mRNA Translation: ADZ17336.1 CH471055 Genomic DNA Translation: EAW64346.1 CH471055 Genomic DNA Translation: EAW64347.1 CH471055 Genomic DNA Translation: EAW64348.1 CH471055 Genomic DNA Translation: EAW64349.1 |
RefSeqi | NP_000452.2, NM_000461.4 NP_001121648.1, NM_001128176.2 NP_001121649.1, NM_001128177.1 NP_001239563.1, NM_001252634.1 XP_005265478.1, XM_005265421.4 XP_005265480.1, XM_005265423.4 XP_005265481.1, XM_005265424.3 XP_006713380.1, XM_006713317.3 XP_006713381.1, XM_006713318.3 XP_011532348.1, XM_011534046.2 XP_011532349.1, XM_011534047.2 XP_011532350.1, XM_011534048.2 XP_011532351.1, XM_011534049.2 XP_011532352.1, XM_011534050.2 XP_011532353.1, XM_011534051.2 XP_011532354.1, XM_011534052.2 XP_016862597.1, XM_017007108.1 XP_016862598.1, XM_017007109.1 XP_016862599.1, XM_017007110.1 XP_016862600.1, XM_017007111.1 XP_016862601.1, XM_017007112.1 |
Genome annotation databases
GeneIDi | 7068 |
KEGGi | hsa:7068 |
MANE-Selecti | ENST00000646209.2; ENSP00000496686.2; NM_001354712.2; NP_001341641.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692825 mRNA Translation: ADZ17336.1 CH471055 Genomic DNA Translation: EAW64346.1 CH471055 Genomic DNA Translation: EAW64347.1 CH471055 Genomic DNA Translation: EAW64348.1 CH471055 Genomic DNA Translation: EAW64349.1 |
RefSeqi | NP_000452.2, NM_000461.4 NP_001121648.1, NM_001128176.2 NP_001121649.1, NM_001128177.1 NP_001239563.1, NM_001252634.1 XP_005265478.1, XM_005265421.4 XP_005265480.1, XM_005265423.4 XP_005265481.1, XM_005265424.3 XP_006713380.1, XM_006713317.3 XP_006713381.1, XM_006713318.3 XP_011532348.1, XM_011534046.2 XP_011532349.1, XM_011534047.2 XP_011532350.1, XM_011534048.2 XP_011532351.1, XM_011534049.2 XP_011532352.1, XM_011534050.2 XP_011532353.1, XM_011534051.2 XP_011532354.1, XM_011534052.2 XP_016862597.1, XM_017007108.1 XP_016862598.1, XM_017007109.1 XP_016862599.1, XM_017007110.1 XP_016862600.1, XM_017007111.1 XP_016862601.1, XM_017007112.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 4548, 504 antibodies from 42 providers |
DNASUi | 7068 |
Genome annotation databases
GeneIDi | 7068 |
KEGGi | hsa:7068 |
MANE-Selecti | ENST00000646209.2; ENSP00000496686.2; NM_001354712.2; NP_001341641.1 |
Organism-specific databases
CTDi | 7068 |
VEuPathDBi | HostDB:ENSG00000151090 |
Phylogenomic databases
HOGENOMi | CLU_007368_18_2_1 |
OMAi | EDCGQAS |
OrthoDBi | 1112927at2759 |
Miscellaneous databases
BioGRID-ORCSi | 7068, 9 hits in 1071 CRISPR screens |
ChiTaRSi | THRB, human |
GenomeRNAii | 7068 |
Gene expression databases
Bgeei | ENSG00000151090, Expressed in Brodmann (1909) area 23 and 212 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001728, ThyrH_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00546, THYROIDHORMR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R2I8_HUMAN | |
Accessioni | A0A024R2I8Primary (citable) accession number: A0A024R2I8 Secondary accession number(s): F1D8N7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 11, 2019 |
Last sequence update: | December 11, 2019 | |
Last modified: | January 19, 2022 | |
This is version 12 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |