UniProtKB - A0A024R2F3 (A0A024R2F3_HUMAN)
Protein
Submitted name:
TatD DNase domain containing 2, isoform CRA_a
Gene
TATDN2
Organism
Homo sapiens (Human)
Status
Functioni
Putative deoxyribonuclease.ARBA annotation
Cofactori
a divalent metal cationARBA annotation
GO - Molecular functioni
- endodeoxyribonuclease activity, producing 5'-phosphomonoesters Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: TatD DNase domain containing 2, isoform CRA_aImported |
Gene namesi | Name:TATDN2Imported ORF Names:hCG_26732Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000157014.10 |
Expressioni
Gene expression databases
Bgeei | ENSG00000157014, Expressed in thymus and 233 other tissues |
ExpressionAtlasi | A0A024R2F3, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 90 | DisorderedSequence analysisAdd BLAST | 90 | |
Regioni | 135 – 181 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 197 – 294 | DisorderedSequence analysisAdd BLAST | 98 | |
Regioni | 318 – 337 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 343 – 364 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 388 – 486 | DisorderedSequence analysisAdd BLAST | 99 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 37 – 51 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 71 – 87 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 141 – 157 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 162 – 181 | PolyampholyteSequence analysisAdd BLAST | 20 | |
Compositional biasi | 252 – 294 | PolyampholyteSequence analysisAdd BLAST | 43 | |
Compositional biasi | 388 – 449 | PolarSequence analysisAdd BLAST | 62 | |
Compositional biasi | 450 – 468 | PolyampholyteSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_019741_1_0_1 |
OMAi | SCLREPC |
OrthoDBi | 207731at2759 |
Family and domain databases
CDDi | cd01310, TatD_DNAse, 1 hit |
InterProi | View protein in InterPro IPR018228, DNase_TatD-rel_CS IPR032466, Metal_Hydrolase IPR001130, TatD_family |
Pfami | View protein in Pfam PF01026, TatD_DNase, 1 hit |
SUPFAMi | SSF51556, SSF51556, 1 hit |
PROSITEi | View protein in PROSITE PS01137, TATD_1, 1 hit PS01090, TATD_2, 1 hit PS01091, TATD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R2F3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASERGKVKH NWSSTSEGCP RKRSCLREPC DVAPSSRPAQ RSASRSGGPS
60 70 80 90 100
SPKRLKAQKE DDVACSRRLS WGSSRRRNNS SSSFSPHFLG PGVGGAASKG
110 120 130 140 150
CLIRNTRGFL SSGGSPLRPA NASLEEMASL EEEACSLKVD SKDSSHNSTN
160 170 180 190 200
SEFAAEAEGQ NDTIEEPNKV QKRKRDRLRD QGSTMIYLKA IQGILGKSMP
210 220 230 240 250
KRKGEAATRA KPSAAEHPSH GEGPARSEGP AKTAEGAARS VTVTAAQKEK
260 270 280 290 300
DATPEVSMEE DKTVPERSSF YDRRVVIDPQ EKPSEEPLGD RRTVIDKCSP
310 320 330 340 350
PLEFLDDSDS HLEIQKHKDR EVVMEHPSSG SDWSDVEEIS TVRFSQEEPV
360 370 380 390 400
SLKPSAVPEP SSFTTDYVMY PPHLYSSPWC DYASYWTSSP KPSSYPSTGS
410 420 430 440 450
SSNDAAQVGK SSRSRMSDYS PNSTGSVQNT SRDMEASEEG WSQNSRSFRF
460 470 480 490 500
SRSSEEREVK EKRTFQEEMP PRPCGGHASS SLPKSHLEPS LEEGFIDTHC
510 520 530 540 550
HLDMLYSKLS FQGTFTKFRK IYSSSFPKEF QGCISDFCDP RTLTDCLWEE
560 570 580 590 600
LLKEDLVWGA FGCHPHFARY YSESQERNLL QALRHPKAVA FGEMGLDYSY
610 620 630 640 650
KCTTPVPEQH KVFERQLQLA VSLKKPLVIH CREADEDLLE IMKKFVPPDY
660 670 680 690 700
KIHRHCFTGS YPVIEPLLKY FPNMSVGFTA VLTYSSAWEA REALRQIPLE
710 720 730 740 750
RIIVETDAPY FLPRQVPKSL CQYAHPGLAL HTVREIARVK DQPLSLTLAA
760
LRENTSRLYS L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471055 Genomic DNA Translation: EAW64071.1 CH471055 Genomic DNA Translation: EAW64072.1 |
RefSeqi | NP_055575.3, NM_014760.3 |
Genome annotation databases
GeneIDi | 9797 |
KEGGi | hsa:9797 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471055 Genomic DNA Translation: EAW64071.1 CH471055 Genomic DNA Translation: EAW64072.1 |
RefSeqi | NP_055575.3, NM_014760.3 |
3D structure databases
SMRi | A0A024R2F3 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 49486, 11 antibodies |
Genome annotation databases
GeneIDi | 9797 |
KEGGi | hsa:9797 |
Organism-specific databases
CTDi | 9797 |
VEuPathDBi | HostDB:ENSG00000157014.10 |
Phylogenomic databases
HOGENOMi | CLU_019741_1_0_1 |
OMAi | SCLREPC |
OrthoDBi | 207731at2759 |
Miscellaneous databases
BioGRID-ORCSi | 9797, 5 hits in 875 CRISPR screens |
ChiTaRSi | TATDN2, human |
GenomeRNAii | 9797 |
Gene expression databases
Bgeei | ENSG00000157014, Expressed in thymus and 233 other tissues |
ExpressionAtlasi | A0A024R2F3, baseline and differential |
Family and domain databases
CDDi | cd01310, TatD_DNAse, 1 hit |
InterProi | View protein in InterPro IPR018228, DNase_TatD-rel_CS IPR032466, Metal_Hydrolase IPR001130, TatD_family |
Pfami | View protein in Pfam PF01026, TatD_DNase, 1 hit |
SUPFAMi | SSF51556, SSF51556, 1 hit |
PROSITEi | View protein in PROSITE PS01137, TATD_1, 1 hit PS01090, TATD_2, 1 hit PS01091, TATD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R2F3_HUMAN | |
Accessioni | A0A024R2F3Primary (citable) accession number: A0A024R2F3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |