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Protein
Submitted name:

Vacuolar protein sorting 4B (Yeast), isoform CRA_a

Gene

VPS4B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolar protein sorting 4B (Yeast), isoform CRA_aImported
Gene namesi
Name:VPS4BImported
ORF Names:hCG_34094Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000119541.9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiA0A024R2C5

Expressioni

Gene expression databases

BgeeiENSG00000119541 Expressed in 227 organ(s), highest expression level in esophagus squamous epithelium
ExpressionAtlasiA0A024R2C5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A024R2C5
SMRiA0A024R2C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 82MITInterPro annotationAdd BLAST79
Domaini166 – 302AAAInterPro annotationAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili62 – 82Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0739 Eukaryota
ENOG410XRHN LUCA
KOiK12196
OMAiTHFKKVK
OrthoDBiEOG091G0Q8J
PhylomeDBiA0A024R2C5

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR027417 P-loop_NTPase
IPR015415 Vps4_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF04212 MIT, 1 hit
PF09336 Vps4_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00745 MIT, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024R2C5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTSPNLQK AIDLASKAAQ EDKAGNYEEA LQLYQHAVQY FLHVVKYEAQ
60 70 80 90 100
GDKAKQSIRA KCTEYLDRAE KLKEYLKNKE KKAQKPVKEG QPSPADEKGN
110 120 130 140 150
DSDGEGESDD PEKKKLQNQL QGAIVIERPN VKWSDVAGLE GAKEALKEAV
160 170 180 190 200
ILPIKFPHLF TGKRTPWRGI LLFGPPGTGK SYLAKAVATE ANNSTFFSIS
210 220 230 240 250
SSDLVSKWLG ESEKLVKNLF QLARENKPSI IFIDEIDSLC GSRSENESEA
260 270 280 290 300
ARRIKTEFLV QMQGVGVDND GILVLGATNI PWVLDSAIRR RFEKRIYIPL
310 320 330 340 350
PEPHARAAMF KLHLGTTQNS LTEADFRELG RKTDGYSGAD ISIIVRDALM
360 370 380 390 400
QPVRKVQSAT HFKKVRGPSR ADPNHLVDDL LTPCSPGDPG AIEMTWMDVP
410 420 430 440
GDKLLEPVVS MSDMLRSLSN TKPTVNEHDL LKLKKFTEDF GQEG
Length:444
Mass (Da):49,302
Last modified:July 9, 2014 - v1
Checksum:i9D565E4B20AF73FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471096 Genomic DNA Translation: EAW63144.1
RefSeqiNP_004860.2, NM_004869.3
UniGeneiHs.126550

Genome annotation databases

GeneIDi9525
KEGGihsa:9525

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471096 Genomic DNA Translation: EAW63144.1
RefSeqiNP_004860.2, NM_004869.3
UniGeneiHs.126550

3D structure databases

ProteinModelPortaliA0A024R2C5
SMRiA0A024R2C5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA0A024R2C5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9525
KEGGihsa:9525

Organism-specific databases

CTDi9525
EuPathDBiHostDB:ENSG00000119541.9

Phylogenomic databases

eggNOGiKOG0739 Eukaryota
ENOG410XRHN LUCA
KOiK12196
OMAiTHFKKVK
OrthoDBiEOG091G0Q8J
PhylomeDBiA0A024R2C5

Miscellaneous databases

ChiTaRSiVPS4B human
GenomeRNAii9525

Gene expression databases

BgeeiENSG00000119541 Expressed in 227 organ(s), highest expression level in esophagus squamous epithelium
ExpressionAtlasiA0A024R2C5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR027417 P-loop_NTPase
IPR015415 Vps4_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF04212 MIT, 1 hit
PF09336 Vps4_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00745 MIT, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R2C5_HUMAN
AccessioniPrimary (citable) accession number: A0A024R2C5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 12, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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