UniProtKB - A0A024R276 (A0A024R276_HUMAN)
Protein
Submitted name:
Cathepsin L, isoform CRA_a
Gene
CTSL
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Cathepsin L, isoform CRA_aImported |
Gene namesi | Name:CTSLImported ORF Names:hCG_30369Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000135047.14 |
Subcellular locationi
Keywords - Cellular componenti
LysosomeARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5014202966 | 18 – 333 | Sequence analysisAdd BLAST | 316 |
Keywords - PTMi
ZymogenARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000135047, Expressed in layer of synovial tissue and 248 other tissues |
ExpressionAtlasi | A0A024R276, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 88 | Inhibitor_I29InterPro annotationAdd BLAST | 60 | |
Domaini | 114 – 332 | Pept_C1InterPro annotationAdd BLAST | 219 |
Sequence similaritiesi
Belongs to the peptidase C1 family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_012184_1_2_1 |
OMAi | GQHYRKS |
OrthoDBi | 1275401at2759 |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R276-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPTLILAAF CLGIASATLT FDHSLEAQWT KWKAMHNRLY GMNEEGWRRA
60 70 80 90 100
VWEKNMKMIE LHNQEYREGK HSFTMAMNAF GDMTSEEFRQ VMNGFQNRKP
110 120 130 140 150
RKGKVFQEPL FYEAPRSVDW REKGYVTPVK NQGQCGSCWA FSATGALEGQ
160 170 180 190 200
MFRKTGRLIS LSEQNLVDCS GPQGNEGCNG GLMDYAFQYV QDNGGLDSEE
210 220 230 240 250
SYPYEATEES CKYNPKYSVA NDTGFVDIPK QEKALMKAVA TVGPISVAID
260 270 280 290 300
AGHESFLFYK EGIYFEPDCS SEDMDHGVLV VGYGFESTES DNNKYWLVKN
310 320 330
SWGEEWGMGG YVKMAKDRRN HCGIASAASY PTV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471089 Genomic DNA Translation: EAW62731.1 CH471089 Genomic DNA Translation: EAW62732.1 CH471089 Genomic DNA Translation: EAW62733.1 CH471089 Genomic DNA Translation: EAW62734.1 CH471089 Genomic DNA Translation: EAW62736.1 |
RefSeqi | NP_001244900.1, NM_001257971.1 NP_001244901.1, NM_001257972.1 NP_001903.1, NM_001912.4 NP_666023.1, NM_145918.2 XP_005251773.1, XM_005251716.3 |
Genome annotation databases
GeneIDi | 1514 |
KEGGi | hsa:1514 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471089 Genomic DNA Translation: EAW62731.1 CH471089 Genomic DNA Translation: EAW62732.1 CH471089 Genomic DNA Translation: EAW62733.1 CH471089 Genomic DNA Translation: EAW62734.1 CH471089 Genomic DNA Translation: EAW62736.1 |
RefSeqi | NP_001244900.1, NM_001257971.1 NP_001244901.1, NM_001257972.1 NP_001903.1, NM_001912.4 NP_666023.1, NM_145918.2 XP_005251773.1, XM_005251716.3 |
3D structure databases
SMRi | A0A024R276 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024R276 |
Protocols and materials databases
Antibodypediai | 4374, 609 antibodies |
Genome annotation databases
GeneIDi | 1514 |
KEGGi | hsa:1514 |
Organism-specific databases
CTDi | 1514 |
EuPathDBi | HostDB:ENSG00000135047.14 |
Phylogenomic databases
HOGENOMi | CLU_012184_1_2_1 |
OMAi | GQHYRKS |
OrthoDBi | 1275401at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1514, 7 hits in 840 CRISPR screens |
ChiTaRSi | CTSL, human |
GenomeRNAii | 1514 |
Gene expression databases
Bgeei | ENSG00000135047, Expressed in layer of synovial tissue and 248 other tissues |
ExpressionAtlasi | A0A024R276, baseline and differential |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R276_HUMAN | |
Accessioni | A0A024R276Primary (citable) accession number: A0A024R276 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |