The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - A0A024R1S7 (A0A024R1S7_HUMAN)
Protein
Submitted name:
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, isoform CRA_a
Gene
SMARCE1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 66 – 134 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- RNA binding Source: Ensembl
GO - Biological processi
- chromatin remodeling Source: InterPro
- neurogenesis Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, isoform CRA_aImported |
Gene namesi | Name:SMARCE1Imported ORF Names:hCG_2005526Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000073584 |
Subcellular locationi
Nucleus
- nBAF complex Source: Ensembl
- npBAF complex Source: Ensembl
- nucleoplasm Source: HPA
- SWI/SNF complex Source: Ensembl
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000073584, Expressed in calcaneal tendon and 185 other tissues |
ExpressionAtlasi | A0A024R1S7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 66 – 134 | HMG boxInterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 42 – 70 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 153 – 175 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 296 – 411 | DisorderedSequence analysisAdd BLAST | 116 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 105 – 136 | Sequence analysisAdd BLAST | 32 | |
Coiled coili | 224 – 258 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 18 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 42 – 56 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 296 – 311 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 324 – 353 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 376 – 398 | Polar residuesSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OMAi | QEYDIER |
OrthoDBi | 1199500at2759 |
PhylomeDBi | A0A024R1S7 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR030089, BAF57 IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
PANTHERi | PTHR46232, PTHR46232, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R1S7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR
60 70 80 90 100
VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNPD LKLWEIGKII
110 120 130 140 150
GGMWRDLTDE EKQEYLNEYE AEKIEYNESM KAYHNSPAYL AYINAKSRAE
160 170 180 190 200
AALEEESRQR QSRMEKGEPY MSIQPAEDPD DYDDGFSMKH TATARFQRNH
210 220 230 240 250
RLISEILSES VVPDVRSVVT TARMQVLKRQ VQSLMVHQRK LEAELLQIEE
260 270 280 290 300
RHQEKKRKFL ESTDSFNNEL KRLCGLKVEV DMEKIAAEIA QAEEQARKRQ
310 320 330 340 350
EEREKEAAEQ AERSQSSIVP EEEQAANKGE EKKDDENIPM ETEETHLEET
360 370 380 390 400
TESQQNGEEG TSTPEDKESG QEGVDSMAEE GTSDSNTGSE SNSATVEEPP
410
TDPIPEDEKK E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471152 Genomic DNA Translation: EAW60671.1 |
RefSeqi | NP_003070.3, NM_003079.4 |
Genome annotation databases
GeneIDi | 6605 |
KEGGi | hsa:6605 |
MANE-Selecti | ENST00000348513.12; ENSP00000323967.6; NM_003079.5; NP_003070.3 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471152 Genomic DNA Translation: EAW60671.1 |
RefSeqi | NP_003070.3, NM_003079.4 |
3D structure databases
SMRi | A0A024R1S7 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 1299, 395 antibodies from 43 providers |
DNASUi | 6605 |
Genome annotation databases
GeneIDi | 6605 |
KEGGi | hsa:6605 |
MANE-Selecti | ENST00000348513.12; ENSP00000323967.6; NM_003079.5; NP_003070.3 |
Organism-specific databases
CTDi | 6605 |
VEuPathDBi | HostDB:ENSG00000073584 |
Phylogenomic databases
OMAi | QEYDIER |
OrthoDBi | 1199500at2759 |
PhylomeDBi | A0A024R1S7 |
Miscellaneous databases
BioGRID-ORCSi | 6605, 528 hits in 1113 CRISPR screens |
ChiTaRSi | SMARCE1, human |
GenomeRNAii | 6605 |
Gene expression databases
Bgeei | ENSG00000073584, Expressed in calcaneal tendon and 185 other tissues |
ExpressionAtlasi | A0A024R1S7, baseline and differential |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR030089, BAF57 IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
PANTHERi | PTHR46232, PTHR46232, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R1S7_HUMAN | |
Accessioni | A0A024R1S7Primary (citable) accession number: A0A024R1S7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | May 25, 2022 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |