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UniProtKB - A0A024R1Q2 (A0A024R1Q2_HUMAN)
Protein
Submitted name:
Chromobox homolog 7, isoform CRA_b
Gene
CBX7
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- developmental process involved in reproduction Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProt
- positive regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Chromobox homolog 7, isoform CRA_bImported |
Gene namesi | Name:CBX7Imported ORF Names:hCG_41710Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000100307 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- PRC1 complex Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSG00000100307, Expressed in cerebellar hemisphere and 251 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 69 | ChromoInterPro annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 190 – 220 | DisorderedSequence analysisAdd BLAST | 31 |
Phylogenomic databases
HOGENOMi | CLU_042051_1_0_1 |
OMAi | PFPLCKP |
Family and domain databases
InterProi | View protein in InterPro IPR043000, CBX7 IPR033773, CBX7_C IPR016197, Chromo-like_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR017984, Chromo_dom_subgr IPR023780, Chromo_domain IPR023779, Chromodomain_CS |
PANTHERi | PTHR47277, PTHR47277, 1 hit |
Pfami | View protein in Pfam PF17218, CBX7_C, 1 hit PF00385, Chromo, 1 hit |
PRINTSi | PR00504, CHROMODOMAIN |
SMARTi | View protein in SMART SM00298, CHROMO, 1 hit |
SUPFAMi | SSF54160, SSF54160, 1 hit |
PROSITEi | View protein in PROSITE PS00598, CHROMO_1, 1 hit PS50013, CHROMO_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R1Q2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD
60 70 80 90 100
PRLVMAYEEK EERDRASGYR KRGPKPKRLL LQRLYSMDLR SSHKAKGKEK
110 120 130 140 150
LCFSLTCPLG SGSPEGVVKA GAPELVDKGP LVPTLPFPLR KPRKAHKYLR
160 170 180 190 200
LSRKKFPPRG PNLESHSHRR ELFLQEPPAP DVLQAAGEWE PAAQPPEEEA
210 220 230 240 250
DADLAEGPPP WTPALPSSEV TVTDITANSI TVTFREAQAA EGFFRDRSGK
F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471095 Genomic DNA Translation: EAW60298.1 CH471095 Genomic DNA Translation: EAW60300.1 |
RefSeqi | NP_783640.1, NM_175709.4 |
Genome annotation databases
GeneIDi | 23492 |
KEGGi | hsa:23492 |
MANE-Selecti | ENST00000216133.10; ENSP00000216133.5; NM_175709.5; NP_783640.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471095 Genomic DNA Translation: EAW60298.1 CH471095 Genomic DNA Translation: EAW60300.1 |
RefSeqi | NP_783640.1, NM_175709.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 26564, 134 antibodies from 29 providers |
DNASUi | 23492 |
Genome annotation databases
GeneIDi | 23492 |
KEGGi | hsa:23492 |
MANE-Selecti | ENST00000216133.10; ENSP00000216133.5; NM_175709.5; NP_783640.1 |
Organism-specific databases
CTDi | 23492 |
VEuPathDBi | HostDB:ENSG00000100307 |
Phylogenomic databases
HOGENOMi | CLU_042051_1_0_1 |
OMAi | PFPLCKP |
Miscellaneous databases
BioGRID-ORCSi | 23492, 5 hits in 1051 CRISPR screens |
GenomeRNAii | 23492 |
Gene expression databases
Bgeei | ENSG00000100307, Expressed in cerebellar hemisphere and 251 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR043000, CBX7 IPR033773, CBX7_C IPR016197, Chromo-like_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR017984, Chromo_dom_subgr IPR023780, Chromo_domain IPR023779, Chromodomain_CS |
PANTHERi | PTHR47277, PTHR47277, 1 hit |
Pfami | View protein in Pfam PF17218, CBX7_C, 1 hit PF00385, Chromo, 1 hit |
PRINTSi | PR00504, CHROMODOMAIN |
SMARTi | View protein in SMART SM00298, CHROMO, 1 hit |
SUPFAMi | SSF54160, SSF54160, 1 hit |
PROSITEi | View protein in PROSITE PS00598, CHROMO_1, 1 hit PS50013, CHROMO_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R1Q2_HUMAN | |
Accessioni | A0A024R1Q2Primary (citable) accession number: A0A024R1Q2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | January 19, 2022 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |