UniProtKB - A0A024R1K7 (A0A024R1K7_HUMAN)
Protein
Submitted name:
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide, isoform CRA_b
Gene
YWHAH
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: Ensembl
- ion channel binding Source: Ensembl
- monooxygenase activity Source: UniProtKB-KW
- protein domain specific binding Source: Ensembl
GO - Biological processi
- intracellular protein transport Source: Ensembl
- negative regulation of dendrite morphogenesis Source: Ensembl
Keywordsi
Molecular function | MonooxygenaseImported, Oxidoreductase |
Names & Taxonomyi
Protein namesi | Submitted name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide, isoform CRA_bImported |
Gene namesi | Name:YWHAHImported ORF Names:hCG_41511Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000128245.14 |
Subcellular locationi
Other locations
- cytoplasm Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000128245, Expressed in cerebral cortex and 240 other tissues |
ExpressionAtlasi | A0A024R1K7, baseline and differential |
Interactioni
GO - Molecular functioni
- actin binding Source: Ensembl
- ion channel binding Source: Ensembl
- protein domain specific binding Source: Ensembl
Protein-protein interaction databases
IntActi | A0A024R1K7, 1 interactor |
Chemistry databases
BindingDBi | A0A024R1K7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 246 | 14_3_3InterPro annotationAdd BLAST | 243 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 72 – 95 | Sequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_058290_0_0_1 |
OMAi | ELPECHP |
OrthoDBi | 1176818at2759 |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R1K7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK
60 70 80 90 100
NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV
110 120 130 140 150
LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS
160 170 180 190 200
EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA
210 220 230 240
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471095 Genomic DNA Translation: EAW60002.1 CH471095 Genomic DNA Translation: EAW60003.1 |
RefSeqi | NP_003396.1, NM_003405.3 |
Genome annotation databases
GeneIDi | 7533 |
KEGGi | hsa:7533 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471095 Genomic DNA Translation: EAW60002.1 CH471095 Genomic DNA Translation: EAW60003.1 |
RefSeqi | NP_003396.1, NM_003405.3 |
3D structure databases
SMRi | A0A024R1K7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0A024R1K7, 1 interactor |
Chemistry databases
BindingDBi | A0A024R1K7 |
Protocols and materials databases
Antibodypediai | 11204, 298 antibodies |
Genome annotation databases
GeneIDi | 7533 |
KEGGi | hsa:7533 |
Organism-specific databases
CTDi | 7533 |
EuPathDBi | HostDB:ENSG00000128245.14 |
Phylogenomic databases
HOGENOMi | CLU_058290_0_0_1 |
OMAi | ELPECHP |
OrthoDBi | 1176818at2759 |
Miscellaneous databases
BioGRID-ORCSi | 7533, 3 hits in 843 CRISPR screens |
ChiTaRSi | YWHAH, human |
GenomeRNAii | 7533 |
Gene expression databases
Bgeei | ENSG00000128245, Expressed in cerebral cortex and 240 other tissues |
ExpressionAtlasi | A0A024R1K7, baseline and differential |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R1K7_HUMAN | |
Accessioni | A0A024R1K7Primary (citable) accession number: A0A024R1K7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |