UniProtKB - A0A024R1J8 (A0A024R1J8_HUMAN)
Protein
Submitted name:
Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_a
Gene
NF2
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 294 | PhosphatidylinositolUniRule annotation | 1 |
GO - Molecular functioni
- actin binding Source: InterPro
GO - Biological processi
- cell-cell junction organization Source: Ensembl
- ectoderm development Source: Ensembl
- hippocampus development Source: Ensembl
- lens fiber cell differentiation Source: Ensembl
- mesoderm formation Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of MAPK cascade Source: Ensembl
- negative regulation of protein kinase activity Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- positive regulation of cell differentiation Source: Ensembl
- regulation of gliogenesis Source: Ensembl
- regulation of neural precursor cell proliferation Source: Ensembl
- regulation of protein localization to nucleus Source: Ensembl
- regulation of protein stability Source: Ensembl
- regulation of stem cell proliferation Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_aImported |
Gene namesi | Name:NF2Imported ORF Names:hCG_2011004Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytoskeleton
- cortical actin cytoskeleton Source: Ensembl
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- cleavage furrow Source: Ensembl
- plasma membrane Source: HPA
Other locations
- adherens junction Source: Ensembl
- apical part of cell Source: Ensembl
- cell body Source: Ensembl
- filopodium Source: Ensembl
- lamellipodium Source: Ensembl
- neuron projection Source: Ensembl
- ruffle Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000186575 Expressed in 219 organ(s), highest expression level in smooth muscle tissue |
ExpressionAtlasi | A0A024R1J8 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 311 | FERMInterPro annotationAdd BLAST | 290 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 76 – 79 | Phosphatidylinositol bindingUniRule annotation | 4 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 313 – 429 | Sequence analysisAdd BLAST | 117 | |
Coiled coili | 441 – 478 | Sequence analysisAdd BLAST | 38 | |
Coiled coili | 518 – 559 | Sequence analysisAdd BLAST | 42 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3529 Eukaryota ENOG410XQFP LUCA |
KOi | K16684 |
OMAi | PRQKTYL |
OrthoDBi | 627741at2759 |
Family and domain databases
CDDi | cd14473 FERM_B-lobe, 1 hit cd13194 FERM_C_ERM, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 1.25.40.1020, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749 Band_41_domain IPR011174 ERM IPR011259 ERM_C_dom IPR041789 ERM_FERM_C IPR000798 Ez/rad/moesin-like IPR014352 FERM/acyl-CoA-bd_prot_sf IPR035963 FERM_2 IPR019748 FERM_central IPR019747 FERM_CS IPR000299 FERM_domain IPR018979 FERM_N IPR018980 FERM_PH-like_C IPR008954 Moesin_tail_sf IPR011993 PH-like_dom_sf IPR029071 Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00769 ERM, 1 hit PF09380 FERM_C, 1 hit PF00373 FERM_M, 1 hit PF09379 FERM_N, 1 hit |
PIRSFi | PIRSF002305 ERM, 1 hit |
PRINTSi | PR00935 BAND41 PR00661 ERMFAMILY |
SMARTi | View protein in SMART SM00295 B41, 1 hit SM01196 FERM_C, 1 hit |
SUPFAMi | SSF47031 SSF47031, 1 hit SSF48678 SSF48678, 1 hit SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660 FERM_1, 1 hit PS00661 FERM_2, 1 hit PS50057 FERM_3, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R1J8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV
60 70 80 90 100
CRTLGLRETW FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF
110 120 130 140 150
YPENAEEELV QEITQHLFFL QVKKQILDEK IYCPPEASVL LASYAVQAKY
160 170 180 190 200
GDYDPSVHKR GFLAQEELLP KRVINLYQMT PEMWEERITA WYAEHRGRAR
210 220 230 240 250
DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG LHIYDPENRL
260 270 280 290 300
TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC
310 320 330 340 350
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE
360 370 380 390 400
RTRDELERRL LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ
410 420 430 440 450
KAAEAEQEMQ RIKATAIRTE EEKRLMEQKV LEAEVLALKM AEESERRAKE
460 470 480 490 500
ADQLKQDLQE AREAERRAKQ KLLEIATKPT YPPMNPIPAP LPPDIPSFNL
510 520 530 540 550
IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN ELKTEIEALK
560 570 580 590
LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471095 Genomic DNA Translation: EAW59814.1 CH471095 Genomic DNA Translation: EAW59824.1 |
RefSeqi | NP_000259.1, NM_000268.3 |
Genome annotation databases
GeneIDi | 4771 |
KEGGi | hsa:4771 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471095 Genomic DNA Translation: EAW59814.1 CH471095 Genomic DNA Translation: EAW59824.1 |
RefSeqi | NP_000259.1, NM_000268.3 |
3D structure databases
SMRi | A0A024R1J8 |
ModBasei | Search... |
Proteomic databases
PRIDEi | A0A024R1J8 |
Genome annotation databases
GeneIDi | 4771 |
KEGGi | hsa:4771 |
Organism-specific databases
CTDi | 4771 |
Phylogenomic databases
eggNOGi | KOG3529 Eukaryota ENOG410XQFP LUCA |
KOi | K16684 |
OMAi | PRQKTYL |
OrthoDBi | 627741at2759 |
Miscellaneous databases
ChiTaRSi | NF2 human |
GenomeRNAii | 4771 |
Gene expression databases
Bgeei | ENSG00000186575 Expressed in 219 organ(s), highest expression level in smooth muscle tissue |
ExpressionAtlasi | A0A024R1J8 baseline and differential |
Family and domain databases
CDDi | cd14473 FERM_B-lobe, 1 hit cd13194 FERM_C_ERM, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 1.25.40.1020, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749 Band_41_domain IPR011174 ERM IPR011259 ERM_C_dom IPR041789 ERM_FERM_C IPR000798 Ez/rad/moesin-like IPR014352 FERM/acyl-CoA-bd_prot_sf IPR035963 FERM_2 IPR019748 FERM_central IPR019747 FERM_CS IPR000299 FERM_domain IPR018979 FERM_N IPR018980 FERM_PH-like_C IPR008954 Moesin_tail_sf IPR011993 PH-like_dom_sf IPR029071 Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00769 ERM, 1 hit PF09380 FERM_C, 1 hit PF00373 FERM_M, 1 hit PF09379 FERM_N, 1 hit |
PIRSFi | PIRSF002305 ERM, 1 hit |
PRINTSi | PR00935 BAND41 PR00661 ERMFAMILY |
SMARTi | View protein in SMART SM00295 B41, 1 hit SM01196 FERM_C, 1 hit |
SUPFAMi | SSF47031 SSF47031, 1 hit SSF48678 SSF48678, 1 hit SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660 FERM_1, 1 hit PS00661 FERM_2, 1 hit PS50057 FERM_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R1J8_HUMAN | |
Accessioni | A0A024R1J8Primary (citable) accession number: A0A024R1J8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | October 16, 2019 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |