UniProtKB - A0A024R0W0 (A0A024R0W0_HUMAN)
Protein
Submitted name:
Solute carrier family 25 (Mitochondrial carrier), member 18, isoform CRA_a
Gene
SLC25A18
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | TransportUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Solute carrier family 25 (Mitochondrial carrier), member 18, isoform CRA_aImported |
Gene namesi | Name:SLC25A18Imported ORF Names:hCG_21534Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182902.13 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 32 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000182902, Expressed in medial globus pallidus and 142 other tissues |
ExpressionAtlasi | A0A024R0W0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 6 – 92 | SolcarPROSITE-ProRule annotationAdd BLAST | 87 | |
Repeati | 100 – 210 | SolcarPROSITE-ProRule annotationAdd BLAST | 111 | |
Repeati | 219 – 308 | SolcarPROSITE-ProRule annotationAdd BLAST | 90 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 141 – 160 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 142 – 160 | PolarSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]UniRule annotationARBA annotation
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_015166_3_4_1 |
OMAi | MTHQDLS |
OrthoDBi | 945010at2759 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
A0A024R0W0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTHQDLSITA KLINGGVAGL VGVTCVFPID LAKTRLQNQH GKAMYKGMID
60 70 80 90 100
CLMKTARAEG FFGMYRGAAV NLTLVTPEKA IKLAANDFFR RLLMEDGMQR
110 120 130 140 150
NLKMEMLAGC GAGMCQVVVT CPMEMLKIQL QDAGRLAVHH QGSASAPSTS
160 170 180 190 200
RSYTTGSAST HRRPSATLIA WELLRTQGLA GLYRGLGATL LRDIPFSIIY
210 220 230 240 250
FPLFANLNNL GFNELAGKAS FAHSFVSGCV AGSIAAVAVT PLDVLKTRIQ
260 270 280 290 300
TLKKGLGEDM YSGITDCARK LWIQEGPSAF MKGAGCRALV IAPLFGIAQG
310
VYFIGIGERI LKCFD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471193 Genomic DNA Translation: EAW57760.1 CH471193 Genomic DNA Translation: EAW57761.1 |
RefSeqi | NP_001290413.1, NM_001303484.1 NP_113669.1, NM_031481.2 XP_011544453.1, XM_011546151.2 XP_011544454.1, XM_011546152.1 XP_011544455.1, XM_011546153.2 XP_011544456.1, XM_011546154.2 XP_016884457.1, XM_017028968.1 |
Genome annotation databases
GeneIDi | 83733 |
KEGGi | hsa:83733 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471193 Genomic DNA Translation: EAW57760.1 CH471193 Genomic DNA Translation: EAW57761.1 |
RefSeqi | NP_001290413.1, NM_001303484.1 NP_113669.1, NM_031481.2 XP_011544453.1, XM_011546151.2 XP_011544454.1, XM_011546152.1 XP_011544455.1, XM_011546153.2 XP_011544456.1, XM_011546154.2 XP_016884457.1, XM_017028968.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 22673, 65 antibodies |
Genome annotation databases
GeneIDi | 83733 |
KEGGi | hsa:83733 |
Organism-specific databases
CTDi | 83733 |
EuPathDBi | HostDB:ENSG00000182902.13 |
Phylogenomic databases
HOGENOMi | CLU_015166_3_4_1 |
OMAi | MTHQDLS |
OrthoDBi | 945010at2759 |
Miscellaneous databases
BioGRID-ORCSi | 83733, 8 hits in 844 CRISPR screens |
ChiTaRSi | SLC25A18, human |
GenomeRNAii | 83733 |
Gene expression databases
Bgeei | ENSG00000182902, Expressed in medial globus pallidus and 142 other tissues |
ExpressionAtlasi | A0A024R0W0, baseline and differential |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R0W0_HUMAN | |
Accessioni | A0A024R0W0Primary (citable) accession number: A0A024R0W0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |