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UniProtKB - A0A024R0L5 (A0A024R0L5_HUMAN)
Protein
[Tau protein] kinase
Gene
GSK3A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 149 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine kinase activity Source: UniProtKB-KW
- tau-protein kinase activity Source: UniProtKB-EC
GO - Biological processi
- glycogen metabolic process Source: UniProtKB-KW
- negative regulation of developmental process Source: UniProt
- negative regulation of signal transduction Source: UniProtKB-KW
- regulation of cellular component organization Source: UniProt
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Signal transduction inhibitorARBA annotation, Transferase |
Biological process | Carbohydrate metabolism, Glycogen metabolismARBA annotation, Wnt signaling pathwayARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GSK3AImported ORF Names:hCG_21895Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000105723 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105723, Expressed in right frontal lobe and 244 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 119 – 403 | Protein kinaseInterPro annotationAdd BLAST | 285 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 96 | DisorderedSequence analysisAdd BLAST | 96 | |
Regioni | 449 – 483 | DisorderedSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.ARBA annotation
Phylogenomic databases
OMAi | NIAHRDC |
OrthoDBi | 990896at2759 |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R0L5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK
60 70 80 90 100
ASVGAMGGGV GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV
110 120 130 140 150
TTVVATLGQG PERSQEVAYT DIKVIGNGSF GVVYQARLAE TRELVAIKKV
160 170 180 190 200
LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY SSGEKKDELY LNLVLEYVPE
210 220 230 240 250
TVYRVARHFT KAKLTIPILY VKVYMYQLFR SLAYIHSQGV CHRDIKPQNL
260 270 280 290 300
LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS
310 320 330 340 350
IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN
360 370 380 390 400
YTEFKFPQIK AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH
410 420 430 440 450
SFFDELRCLG TQLPNNRPLP PLFNFSAGEL SIQPSLNAIL IPPHLRSPAG
460 470 480
TTTLTPSSQA LTETPTSSDW QSTDATPTLT NSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471126 Genomic DNA Translation: EAW57114.1 CH471126 Genomic DNA Translation: EAW57115.1 |
RefSeqi | NP_063937.2, NM_019884.2 |
Genome annotation databases
GeneIDi | 2931 |
KEGGi | hsa:2931 |
MANE-Selecti | ENST00000222330.8; ENSP00000222330.3; NM_019884.3; NP_063937.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471126 Genomic DNA Translation: EAW57114.1 CH471126 Genomic DNA Translation: EAW57115.1 |
RefSeqi | NP_063937.2, NM_019884.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A0A024R0L5, 1 interactor |
Protocols and materials databases
Antibodypediai | 3833, 1223 antibodies from 48 providers |
DNASUi | 2931 |
Genome annotation databases
GeneIDi | 2931 |
KEGGi | hsa:2931 |
MANE-Selecti | ENST00000222330.8; ENSP00000222330.3; NM_019884.3; NP_063937.2 |
Organism-specific databases
CTDi | 2931 |
VEuPathDBi | HostDB:ENSG00000105723 |
Phylogenomic databases
OMAi | NIAHRDC |
OrthoDBi | 990896at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2931, 13 hits in 1078 CRISPR screens |
ChiTaRSi | GSK3A, human |
GenomeRNAii | 2931 |
Gene expression databases
Bgeei | ENSG00000105723, Expressed in right frontal lobe and 244 other tissues |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R0L5_HUMAN | |
Accessioni | A0A024R0L5Primary (citable) accession number: A0A024R0L5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | January 19, 2022 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |