UniProtKB - A0A024R0K5 (A0A024R0K5_HUMAN)
Protein
Submitted name:
Carcinoembryonic antigen-related cell adhesion molecule 5
Gene
CEACAM5
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Carcinoembryonic antigen-related cell adhesion molecule 5ImportedSubmitted name: Carcinoembryonic antigen-related cell adhesion molecule 5, isoform CRA_aImported |
Gene namesi | Name:CEACAM5Imported ORF Names:hCG_1642477Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000105388.15 |
HGNCi | HGNC:1817, CEACAM5 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: HPA
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_5014008696 | 35 – 702 | Sequence analysisAdd BLAST | 668 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105388, Expressed in colonic mucosa and 133 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 145 – 232 | Ig-likeInterPro annotationAdd BLAST | 88 | |
Domaini | 240 – 315 | Ig-likeInterPro annotationAdd BLAST | 76 | |
Domaini | 323 – 410 | Ig-likeInterPro annotationAdd BLAST | 88 | |
Domaini | 418 – 495 | Ig-likeInterPro annotationAdd BLAST | 78 | |
Domaini | 501 – 588 | Ig-likeInterPro annotationAdd BLAST | 88 | |
Domaini | 593 – 675 | Ig-likeInterPro annotationAdd BLAST | 83 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00960000186634 |
OMAi | RNDTTSY |
OrthoDBi | 998214at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF13895, Ig_2, 3 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 7 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 7 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
A0A024R0K5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE
60 70 80 90 100
VLLLVHNLPQ HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI
110 120 130 140 150
IYPNASLLIQ NIIQNDTGFY TLHVIKSDLV NEEATGQFRV YPELPKPSIS
160 170 180 190 200
SNNSKPVEDK DAVAFTCEPE TQDATYLWWV NNQSLPVSPR LQLSNGNRTL
210 220 230 240 250
TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP TISPLNTSYR
260 270 280 290 300
SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ
310 320 330 340 350
AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ
360 370 380 390 400
NTTYLWWVNN QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNELS
410 420 430 440 450
VDHSDPVILN VLYGPDDPTI SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL
460 470 480 490 500
IDGNIQQHTQ ELFISNITEK NSGLYTCQAN NSASGHSRTT VKTITVSAEL
510 520 530 540 550
PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS LPVSPRLQLS
560 570 580 590 600
NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP
610 620 630 640 650
PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN
660 670 680 690 700
GTYACFVSNL ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA
LI
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP06731 | CEAM5_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM5 CEA | 702 | Annotation score: | ||
A0A087WYX0 | A0A087WYX0_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM5 | 524 | Annotation score: | ||
T2HUW8 | T2HUW8_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM5 | 346 | Annotation score: | ||
M0QX98 | M0QX98_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM5 | 141 | Annotation score: | ||
M0R3J1 | M0R3J1_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM5 | 194 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC243967 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57059.1 CH471126 Genomic DNA Translation: EAW57060.1 |
RefSeqi | NP_001278413.1, NM_001291484.2 NP_004354.3, NM_004363.5 |
Genome annotation databases
Ensembli | ENST00000617332; ENSP00000482303; ENSG00000105388 |
GeneIDi | 1048 |
KEGGi | hsa:1048 |
UCSCi | uc060zci.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC243967 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57059.1 CH471126 Genomic DNA Translation: EAW57060.1 |
RefSeqi | NP_001278413.1, NM_001291484.2 NP_004354.3, NM_004363.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3500, 3216 antibodies |
Genome annotation databases
Ensembli | ENST00000617332; ENSP00000482303; ENSG00000105388 |
GeneIDi | 1048 |
KEGGi | hsa:1048 |
UCSCi | uc060zci.1, human |
Organism-specific databases
CTDi | 1048 |
EuPathDBi | HostDB:ENSG00000105388.15 |
HGNCi | HGNC:1817, CEACAM5 |
OpenTargetsi | ENSG00000105388 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00960000186634 |
OMAi | RNDTTSY |
OrthoDBi | 998214at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1048, 15 hits in 845 CRISPR screens |
ChiTaRSi | CEACAM5, human |
GenomeRNAii | 1048 |
Gene expression databases
Bgeei | ENSG00000105388, Expressed in colonic mucosa and 133 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF13895, Ig_2, 3 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 7 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 7 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R0K5_HUMAN | |
Accessioni | A0A024R0K5Primary (citable) accession number: A0A024R0K5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |