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Protein
Submitted name:

Carcinoembryonic antigen-related cell adhesion molecule 5, isoform CRA_a

Gene

CEACAM5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Carcinoembryonic antigen-related cell adhesion molecule 5, isoform CRA_aImported
Gene namesi
Name:CEACAM5Imported
ORF Names:hCG_1642477Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105388.15
HGNCiHGNC:1817 CEACAM5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105388

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_501400869635 – 702Sequence analysisAdd BLAST668

Proteomic databases

EPDiA0A024R0K5
PeptideAtlasiA0A024R0K5
PRIDEiA0A024R0K5

Expressioni

Gene expression databases

BgeeiENSG00000105388 Expressed in 131 organ(s), highest expression level in colonic mucosa
ExpressionAtlasiA0A024R0K5 baseline and differential

Structurei

3D structure databases

SMRiA0A024R0K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 232Ig-likeInterPro annotationAdd BLAST88
Domaini240 – 315Ig-likeInterPro annotationAdd BLAST76
Domaini323 – 410Ig-likeInterPro annotationAdd BLAST88
Domaini418 – 495Ig-likeInterPro annotationAdd BLAST78
Domaini501 – 588Ig-likeInterPro annotationAdd BLAST88
Domaini593 – 675Ig-likeInterPro annotationAdd BLAST83

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
GeneTreeiENSGT00760000119187
KOiK06499
OMAiCQAHNSD
OrthoDBiEOG091G0AMM

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

A0A024R0K5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE
60 70 80 90 100
VLLLVHNLPQ HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI
110 120 130 140 150
IYPNASLLIQ NIIQNDTGFY TLHVIKSDLV NEEATGQFRV YPELPKPSIS
160 170 180 190 200
SNNSKPVEDK DAVAFTCEPE TQDATYLWWV NNQSLPVSPR LQLSNGNRTL
210 220 230 240 250
TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP TISPLNTSYR
260 270 280 290 300
SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ
310 320 330 340 350
AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ
360 370 380 390 400
NTTYLWWVNN QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNELS
410 420 430 440 450
VDHSDPVILN VLYGPDDPTI SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL
460 470 480 490 500
IDGNIQQHTQ ELFISNITEK NSGLYTCQAN NSASGHSRTT VKTITVSAEL
510 520 530 540 550
PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS LPVSPRLQLS
560 570 580 590 600
NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP
610 620 630 640 650
PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN
660 670 680 690 700
GTYACFVSNL ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA

LI
Length:702
Mass (Da):76,796
Last modified:July 9, 2014 - v1
Checksum:i6299AE26CDDBDB5C
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P06731CEAM5_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5 CEA
702Annotation score:
A0A087WYX0A0A087WYX0_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
524Annotation score:
T2HUW8T2HUW8_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
346Annotation score:
M0R3J1M0R3J1_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
194Annotation score:
M0QX98M0QX98_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
141Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC243967 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57059.1
CH471126 Genomic DNA Translation: EAW57060.1
RefSeqiNP_001278413.1, NM_001291484.2
NP_004354.3, NM_004363.5
UniGeneiHs.709196

Genome annotation databases

EnsembliENST00000617332; ENSP00000482303; ENSG00000105388
GeneIDi1048
KEGGihsa:1048
UCSCiuc060zci.1 human

Similar proteinsi

Entry informationi

Entry nameiA0A024R0K5_HUMAN
AccessioniPrimary (citable) accession number: A0A024R0K5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 12, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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