UniProtKB - A0A024R050 (A0A024R050_HUMAN)
Protein
Amino acid transporter
Gene
SLC1A3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- symporter activity Source: UniProtKB-UniRule
Keywordsi
Biological process | SymportUniRule annotationARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Amino acid transporterUniRule annotation |
Gene namesi | Name:SLC1A3Imported ORF Names:hCG_36855Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000079215.13 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 49 – 71 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 91 – 111 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 123 – 145 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 241 – 260 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 281 – 302 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 314 – 339 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 346 – 365 | HelicalUniRule annotationAdd BLAST | 20 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000079215, Expressed in cerebellum and 222 other tissues |
ExpressionAtlasi | A0A024R050, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
OMAi | GIMFVVH |
OrthoDBi | 1184392at2759 |
PhylomeDBi | A0A024R050 |
Family and domain databases
Gene3Di | 1.10.3860.10, 2 hits |
InterProi | View protein in InterPro IPR001991, Na-dicarboxylate_symporter IPR018107, Na-dicarboxylate_symporter_CS IPR036458, Na:dicarbo_symporter_sf |
Pfami | View protein in Pfam PF00375, SDF, 1 hit |
SUPFAMi | SSF118215, SSF118215, 1 hit |
PROSITEi | View protein in PROSITE PS00713, NA_DICARBOXYL_SYMP_1, 1 hit PS00714, NA_DICARBOXYL_SYMP_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R050-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKSNGEEPK MGGRMERFQQ GVRKRTLLAK KKVQNITKED VKSYLFRNAF
60 70 80 90 100
VLLTVTAVIV GTILGFTLRP YRMSYREVKY FSFPGELLMR MLQMLVLPLI
110 120 130 140 150
ISSLVTGMAA LDSKASGKMG MRAVVYYMTT TIIAVVIGII IVIIIHPGKG
160 170 180 190 200
TKENMHREGK IVRVTAADAF LDLIRNMFPP NLVEACFKQF KTNYEKRSFK
210 220 230 240 250
VPIQANETLV GAVINNVSEA METLTRITEE LVPVPGSVNG VNALGLVVFS
260 270 280 290 300
MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP VGILFLIAGK
310 320 330 340 350
IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG
360 370 380 390 400
GLLQALITAL GTSSSSATLP ITFKCLEENN GVDKRVTRFV LPVGATINMD
410 420 430 440 450
GTALYEALAA IFIAQVNNFE LNFGQIITIS ITATAASIGA AGIPQAGLVT
460 470 480 490 500
MVIVLTSVGL PTDDITLIIA VDWFLDRLRT TTNVLGDSLG AGIVEHLSRH
510 520 530 540
ELKNRDVEMG NSVIEENEMK KPYQLIAQDN ETEKPIDSET KM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471119 Genomic DNA Translation: EAW55946.1 |
RefSeqi | NP_004163.3, NM_004172.4 XP_005248399.1, XM_005248342.2 |
Genome annotation databases
GeneIDi | 6507 |
KEGGi | hsa:6507 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471119 Genomic DNA Translation: EAW55946.1 |
RefSeqi | NP_004163.3, NM_004172.4 XP_005248399.1, XM_005248342.2 |
3D structure databases
SMRi | A0A024R050 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024R050 |
Protocols and materials databases
Antibodypediai | 22936, 389 antibodies |
DNASUi | 6507 |
Genome annotation databases
GeneIDi | 6507 |
KEGGi | hsa:6507 |
Organism-specific databases
CTDi | 6507 |
VEuPathDBi | HostDB:ENSG00000079215.13 |
Phylogenomic databases
OMAi | GIMFVVH |
OrthoDBi | 1184392at2759 |
PhylomeDBi | A0A024R050 |
Miscellaneous databases
BioGRID-ORCSi | 6507, 6 hits in 989 CRISPR screens |
ChiTaRSi | SLC1A3, human |
GenomeRNAii | 6507 |
Gene expression databases
Bgeei | ENSG00000079215, Expressed in cerebellum and 222 other tissues |
ExpressionAtlasi | A0A024R050, baseline and differential |
Family and domain databases
Gene3Di | 1.10.3860.10, 2 hits |
InterProi | View protein in InterPro IPR001991, Na-dicarboxylate_symporter IPR018107, Na-dicarboxylate_symporter_CS IPR036458, Na:dicarbo_symporter_sf |
Pfami | View protein in Pfam PF00375, SDF, 1 hit |
SUPFAMi | SSF118215, SSF118215, 1 hit |
PROSITEi | View protein in PROSITE PS00713, NA_DICARBOXYL_SYMP_1, 1 hit PS00714, NA_DICARBOXYL_SYMP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R050_HUMAN | |
Accessioni | A0A024R050Primary (citable) accession number: A0A024R050 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |