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Protein
Submitted name:

Serpin B6

Gene

SERPINB6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Serpin B6Imported
Submitted name:
Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_dImported
Gene namesi
Name:SERPINB6Imported
ORF Names:hCG_22875Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124570.17
HGNCiHGNC:8950 SERPINB6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124570

PTM / Processingi

Proteomic databases

EPDiA0A024QZX5
PRIDEiA0A024QZX5

Expressioni

Gene expression databases

BgeeiENSG00000124570 Expressed in 226 organ(s), highest expression level in right testis
ExpressionAtlasiA0A024QZX5 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 380SERPINInterPro annotationAdd BLAST364

Sequence similaritiesi

Belongs to the serpin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

A0A024QZX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAIMDVLAE ANGTFALNLL KTLGKDNSKN VFFSPMSMSC ALAMVYMGAK
60 70 80 90 100
GNTAAQMAQI LSFNKSGGGG DIHQGFQSLL TEVNKTGTQY LLRMANRLFG
110 120 130 140 150
EKSCDFLSSF RDSCQKFYQA EMEELDFISA VEKSRKHINT WVAEKTEGKI
160 170 180 190 200
AELLSPGSVD PLTRLVLVNA VYFRGNWDEQ FDKENTEERL FKVSKNEEKP
210 220 230 240 250
VQMMFKQSTF KKTYIGEIFT QILVLPYVGK ELNMIIMLPD ETTDLRTVEK
260 270 280 290 300
ELTYEKFVEW TRLDMMDEEE VEVSLPRFKL EESYDMESVL RNLGMTDAFE
310 320 330 340 350
LGKADFSGMS QTDLSLSKVV HKSFVEVNEE GTEAAAATAA IMMMRCARFV
360 370 380
PRFCADHPFL FFIQHSKTNG ILFCGRFSSP
Length:380
Mass (Da):43,024
Last modified:July 9, 2014 - v1
Checksum:iCC74C679CAA6D4F7
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P35237SPB6_HUMAN
Serpin B6
SERPINB6 PI6, PTI
376Annotation score:
A0A2R8YDD0A0A2R8YDD0_HUMAN
Serpin B6
SERPINB6
61Annotation score:
A0A2R8Y5S1A0A2R8Y5S1_HUMAN
Serpin B6
SERPINB6
60Annotation score:
A0A087X1N8A0A087X1N8_HUMAN
Serpin B6
SERPINB6 hCG_22875
395Annotation score:
A0A2R8YD12A0A2R8YD12_HUMAN
Serpin B6
SERPINB6
332Annotation score:
A0A2R8Y6A7A0A2R8Y6A7_HUMAN
Serpin B6
SERPINB6
171Annotation score:
A0A2R8Y517A0A2R8Y517_HUMAN
Serpin B6
SERPINB6
77Annotation score:
A0A2R8Y6N4A0A2R8Y6N4_HUMAN
Serpin B6
SERPINB6
81Annotation score:
A0A2R8Y5Y8A0A2R8Y5Y8_HUMAN
Serpin B6
SERPINB6
11Annotation score:
A0A2R8Y7E5A0A2R8Y7E5_HUMAN
Serpin B6
SERPINB6
17Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133351 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55102.1
CH471087 Genomic DNA Translation: EAW55103.1
RefSeqiNP_001182220.2, NM_001195291.2
XP_016866429.1, XM_017010940.1
UniGeneiHs.519523
Hs.731506

Genome annotation databases

EnsembliENST00000616722; ENSP00000481398; ENSG00000124570
ENST00000645580; ENSP00000495362; ENSG00000124570
GeneIDi5269
UCSCiuc003mun.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133351 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55102.1
CH471087 Genomic DNA Translation: EAW55103.1
RefSeqiNP_001182220.2, NM_001195291.2
XP_016866429.1, XM_017010940.1
UniGeneiHs.519523
Hs.731506

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiA0A024QZX5
PRIDEiA0A024QZX5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000616722; ENSP00000481398; ENSG00000124570
ENST00000645580; ENSP00000495362; ENSG00000124570
GeneIDi5269
UCSCiuc003mun.5 human

Organism-specific databases

CTDi5269
EuPathDBiHostDB:ENSG00000124570.17
HGNCiHGNC:8950 SERPINB6
OpenTargetsiENSG00000124570
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789

Miscellaneous databases

ChiTaRSiSERPINB6 human
GenomeRNAii5269

Gene expression databases

BgeeiENSG00000124570 Expressed in 226 organ(s), highest expression level in right testis
ExpressionAtlasiA0A024QZX5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024QZX5_HUMAN
AccessioniPrimary (citable) accession number: A0A024QZX5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 10, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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