UniProtKB - A0A024QZX0 (A0A024QZX0_HUMAN)
Protein
TBC1 domain family member 7
Gene
TBC1D7
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- activation of GTPase activity Source: Ensembl
- negative regulation of TOR signaling Source: Ensembl
Keywordsi
Molecular function | GTPase activationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: TBC1 domain family member 7ARBA annotation |
Gene namesi | Name:TBC1D7Imported ORF Names:hCG_37421Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000145979.17 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145979, Expressed in cortical plate and 200 other tissues |
ExpressionAtlasi | A0A024QZX0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 231 | Rab-GAP TBCInterPro annotationAdd BLAST | 182 |
Phylogenomic databases
OMAi | KIWDKVC |
OrthoDBi | 1440539at2759 |
PhylomeDBi | A0A024QZX0 |
Family and domain databases
Gene3Di | 1.10.8.680, 1 hit |
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf IPR039842, TBC1D7 IPR043039, TBC1D7_dom2 |
PANTHERi | PTHR13530, PTHR13530, 1 hit |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024QZX0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEDSQRNFR SVYYEKVGFR GVEEKKSLEI LLKDDRLDTE KLCTFSQRFP
60 70 80 90 100
LPSMYRALVW KVLLGILPPH HESHAKVMMY RKEQYLDVLH ALKVVRFVSD
110 120 130 140 150
ATPQAEVYLR MYQLESGKLP RSPSFPLEPD DEVFLAIAKA MEEMVEDSVD
160 170 180 190 200
CYWITRRFVN QLNTKYRDSL PQLPKAFEQY LNLEDGRLLT HLRMCSAAPK
210 220 230 240 250
LPYDLWFKRC FAGCLPESSL QRVWDKVVSG SCKILVFVAV EILLTFKIKV
260 270 280 290
MALNSAEKIT KFLENIPQDS SDAIVSKAID LWHKHCGTPV HSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471087 Genomic DNA Translation: EAW55326.1 |
RefSeqi | NP_001137436.1, NM_001143964.3 NP_001137437.1, NM_001143965.3 NP_001305734.1, NM_001318805.1 NP_001305738.1, NM_001318809.1 NP_057579.1, NM_016495.5 |
Genome annotation databases
GeneIDi | 107080638 51256 |
KEGGi | hsa:107080638 hsa:51256 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471087 Genomic DNA Translation: EAW55326.1 |
RefSeqi | NP_001137436.1, NM_001143964.3 NP_001137437.1, NM_001143965.3 NP_001305734.1, NM_001318805.1 NP_001305738.1, NM_001318809.1 NP_057579.1, NM_016495.5 |
3D structure databases
SMRi | A0A024QZX0 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 24944, 98 antibodies |
DNASUi | 51256 |
Genome annotation databases
GeneIDi | 107080638 51256 |
KEGGi | hsa:107080638 hsa:51256 |
Organism-specific databases
CTDi | 107080638 51256 |
VEuPathDBi | HostDB:ENSG00000145979.17 |
Phylogenomic databases
OMAi | KIWDKVC |
OrthoDBi | 1440539at2759 |
PhylomeDBi | A0A024QZX0 |
Miscellaneous databases
BioGRID-ORCSi | 107080638, 0 hits in 3 CRISPR screens 51256, 10 hits in 1004 CRISPR screens |
Gene expression databases
Bgeei | ENSG00000145979, Expressed in cortical plate and 200 other tissues |
ExpressionAtlasi | A0A024QZX0, baseline and differential |
Family and domain databases
Gene3Di | 1.10.8.680, 1 hit |
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf IPR039842, TBC1D7 IPR043039, TBC1D7_dom2 |
PANTHERi | PTHR13530, PTHR13530, 1 hit |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024QZX0_HUMAN | |
Accessioni | A0A024QZX0Primary (citable) accession number: A0A024QZX0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 41 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |