UniProtKB - A0A024QZU0 (A0A024QZU0_HUMAN)
Protein
Submitted name:
Receptor (TNFRSF)-interacting serine-threonine kinase 1, isoform CRA_a
Gene
RIPK1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: InterPro
- death receptor binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein kinase activity Source: InterPro
GO - Biological processi
- positive regulation of necroptotic process Source: Ensembl
- programmed cell death Source: UniProtKB-KW
- signal transduction Source: InterPro
Keywordsi
Molecular function | KinaseImported, ReceptorImported, Transferase |
Biological process | NecrosisARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Receptor (TNFRSF)-interacting serine-threonine kinase 1, isoform CRA_aImported |
Gene namesi | Name:RIPK1Imported ORF Names:hCG_22874Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000137275.13 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- membrane raft Source: Ensembl
- protein-containing complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000137275, Expressed in sural nerve and 199 other tissues |
ExpressionAtlasi | A0A024QZU0, baseline and differential |
Interactioni
GO - Molecular functioni
- death receptor binding Source: Ensembl
Chemistry databases
BindingDBi | A0A024QZU0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 289 | Protein kinaseInterPro annotationAdd BLAST | 273 | |
Domaini | 583 – 669 | DeathInterPro annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 331 – 354 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 389 – 458 | DisorderedSequence analysisAdd BLAST | 70 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 294 – 314 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 331 – 346 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 403 – 420 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 423 – 458 | PolarSequence analysisAdd BLAST | 36 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_017229_0_0_1 |
OMAi | NDFHIKI |
OrthoDBi | 346354at2759 |
Family and domain databases
CDDi | cd08777, Death_RIP1, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR025735, RHIM_dom IPR037934, RIP1_Death IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF12721, RHIM, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024QZU0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPDMSLNVI KMKSSDFLES AELDSGGFGK VSLCFHRTQG LMIMKTVYKG
60 70 80 90 100
PNCIEHNEAL LEEAKMMNRL RHSRVVKLLG VIIEEGKYSL VMEYMEKGNL
110 120 130 140 150
MHVLKAEMST PLSVKGRIIL EIIEGMCYLH GKGVIHKDLK PENILVDNDF
160 170 180 190 200
HIKIADLGLA SFKMWSKLNN EEHNELREVD GTAKKNGGTL YYMAPEHLND
210 220 230 240 250
VNAKPTEKSD VYSFAVVLWA IFANKEPYEN AICEQQLIMC IKSGNRPDVD
260 270 280 290 300
DITEYCPREI ISLMKLCWEA NPEARPTFPG IEEKFRPFYL SQLEESVEED
310 320 330 340 350
VKSLKKEYSN ENAVVKRMQS LQLDCVAVPS SRSNSATEQP GSLHSSQGLG
360 370 380 390 400
MGPVEESWFA PSLEHPQEEN EPSLQSKLQD EANYHLYGSR MDRQTKQQPR
410 420 430 440 450
QNVAYNREEE RRRRVSHDPF AQQRPYENFQ NTEGKGTAYS SAASHGNAVH
460 470 480 490 500
QPSGLTSQPQ VLYQNNGLYS SHGFGTRPLD PGTAGPRVWY RPIPSHMPSL
510 520 530 540 550
HNIPVPETNY LGNTPTMPFS SLPPTDESIK YTIYNSTGIQ IGAYNYMEIG
560 570 580 590 600
GTSSSLLDST NTNFKEEPAA KYQAIFDNTT SLTDKHLDPI RENLGKHWKN
610 620 630 640 650
CARKLGFTQS QIDEIDHDYE RDGLKEKVYQ MLQKWVMREG IKGATVGKLA
660 670
QALHQCSRID LLSSLIYVSQ N
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471087 Genomic DNA Translation: EAW55115.1 CH471087 Genomic DNA Translation: EAW55117.1 |
RefSeqi | NP_003795.2, NM_003804.4 XP_005249514.2, XM_005249457.3 |
Genome annotation databases
GeneIDi | 8737 |
KEGGi | hsa:8737 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471087 Genomic DNA Translation: EAW55115.1 CH471087 Genomic DNA Translation: EAW55117.1 |
RefSeqi | NP_003795.2, NM_003804.4 XP_005249514.2, XM_005249457.3 |
3D structure databases
SMRi | A0A024QZU0 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024QZU0 |
Protocols and materials databases
Antibodypediai | 4145, 613 antibodies |
DNASUi | 8737 |
Genome annotation databases
GeneIDi | 8737 |
KEGGi | hsa:8737 |
Organism-specific databases
CTDi | 8737 |
VEuPathDBi | HostDB:ENSG00000137275.13 |
Phylogenomic databases
HOGENOMi | CLU_017229_0_0_1 |
OMAi | NDFHIKI |
OrthoDBi | 346354at2759 |
Miscellaneous databases
BioGRID-ORCSi | 8737, 25 hits in 1031 CRISPR screens |
ChiTaRSi | RIPK1, human |
GenomeRNAii | 8737 |
Gene expression databases
Bgeei | ENSG00000137275, Expressed in sural nerve and 199 other tissues |
ExpressionAtlasi | A0A024QZU0, baseline and differential |
Family and domain databases
CDDi | cd08777, Death_RIP1, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR025735, RHIM_dom IPR037934, RIP1_Death IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF12721, RHIM, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024QZU0_HUMAN | |
Accessioni | A0A024QZU0Primary (citable) accession number: A0A024QZU0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |