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UniProtKB - A0A024QZT0 (A0A024QZT0_HUMAN)
Protein
Voltage-dependent anion-selective channel protein 2
Gene
VDAC2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- porin activity Source: UniProtKB-KW
- voltage-gated anion channel activity Source: InterPro
GO - Biological processi
- negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of protein polymerization Source: Ensembl
Keywordsi
Molecular function | PorinARBA annotation |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent anion-selective channel protein 2ARBA annotationAlternative name(s): Outer mitochondrial membrane protein porin 2ARBA annotation |
Gene namesi | Name:VDAC2Imported ORF Names:hCG_23984Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000165637 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane ARBA annotation
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
- mitochondrion Source: HPA
Other locations
- pore complex Source: UniProtKB-KW
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membraneARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000165637, Expressed in ectocervix and 133 other tissues |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the eukaryotic mitochondrial porin family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane beta strandARBA annotationPhylogenomic databases
HOGENOMi | CLU_044399_2_0_1 |
OMAi | PWSWRLN |
Family and domain databases
CDDi | cd07306, Porin3_VDAC, 1 hit |
Gene3Di | 2.40.160.10, 1 hit |
InterProi | View protein in InterPro IPR023614, Porin_dom_sf IPR001925, Porin_Euk IPR027246, Porin_Euk/Tom40 IPR030277, VDAC2 |
PANTHERi | PTHR11743, PTHR11743, 1 hit PTHR11743:SF12, PTHR11743:SF12, 1 hit |
Pfami | View protein in Pfam PF01459, Porin_3, 1 hit |
PRINTSi | PR00185, EUKARYTPORIN |
PROSITEi | View protein in PROSITE PS00558, EUKARYOTIC_PORIN, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024QZT0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV
60 70 80 90 100
EFSTSGSSNT DTGKVTGTLE TKYKWCEYGL TFTEKWNTDN TLGTEIAIED
110 120 130 140 150
QICQGLKLTF DTTFSPNTGK KSGKIKSSYK RECINLGCDV DFDFAGPAIH
160 170 180 190 200
GSAVFGYEGW LAGYQMTFDS AKSKLTRNNF AVGYRTGDFQ LHTNVNDGTE
210 220 230 240 250
FGGSIYQKVC EDLDTSVNLA WTSGTNCTRF GIAAKYQLDP TASISAKVNN
260 270 280 290
SSLIGVGYTQ TLRPGVKLTL SALVDGKSIN AGGHKVGLAL ELEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ891299 mRNA Translation: ADO22161.1 CH471083 Genomic DNA Translation: EAW54573.1 CH471083 Genomic DNA Translation: EAW54574.1 |
RefSeqi | NP_001171752.1, NM_001184823.1 NP_001311017.1, NM_001324088.1 NP_003366.2, NM_003375.4 |
Genome annotation databases
GeneIDi | 7417 |
KEGGi | hsa:7417 |
MANE-Selecti | ENST00000332211.11; ENSP00000361686.3; NM_001391963.1; NP_001378892.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ891299 mRNA Translation: ADO22161.1 CH471083 Genomic DNA Translation: EAW54573.1 CH471083 Genomic DNA Translation: EAW54574.1 |
RefSeqi | NP_001171752.1, NM_001184823.1 NP_001311017.1, NM_001324088.1 NP_003366.2, NM_003375.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 29670, 301 antibodies from 32 providers |
DNASUi | 7417 |
Genome annotation databases
GeneIDi | 7417 |
KEGGi | hsa:7417 |
MANE-Selecti | ENST00000332211.11; ENSP00000361686.3; NM_001391963.1; NP_001378892.1 |
Organism-specific databases
CTDi | 7417 |
VEuPathDBi | HostDB:ENSG00000165637 |
Phylogenomic databases
HOGENOMi | CLU_044399_2_0_1 |
OMAi | PWSWRLN |
Miscellaneous databases
BioGRID-ORCSi | 7417, 128 hits in 1082 CRISPR screens |
ChiTaRSi | VDAC2, human |
GenomeRNAii | 7417 |
Gene expression databases
Bgeei | ENSG00000165637, Expressed in ectocervix and 133 other tissues |
Family and domain databases
CDDi | cd07306, Porin3_VDAC, 1 hit |
Gene3Di | 2.40.160.10, 1 hit |
InterProi | View protein in InterPro IPR023614, Porin_dom_sf IPR001925, Porin_Euk IPR027246, Porin_Euk/Tom40 IPR030277, VDAC2 |
PANTHERi | PTHR11743, PTHR11743, 1 hit PTHR11743:SF12, PTHR11743:SF12, 1 hit |
Pfami | View protein in Pfam PF01459, Porin_3, 1 hit |
PRINTSi | PR00185, EUKARYTPORIN |
PROSITEi | View protein in PROSITE PS00558, EUKARYOTIC_PORIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024QZT0_HUMAN | |
Accessioni | A0A024QZT0Primary (citable) accession number: A0A024QZT0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | May 25, 2022 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |