UniProtKB - A0A024QZS3 (A0A024QZS3_HUMAN)
Protein
Lipid phosphate phosphohydrolase 1
Gene
PPAP2A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphateARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphateARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphateARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphateARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphateARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphateARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- EC:3.1.3.4ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H+ + phosphateARBA annotationEC:3.1.3.81ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- EC:3.1.3.106ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
: phospholipid metabolism Pathwayi
This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.ARBA annotationView all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.
GO - Molecular functioni
- diacylglycerol diphosphate phosphatase activity Source: UniProtKB-EC
- phosphatidate phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- phospholipid metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | HydrolaseARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
Names & Taxonomyi
Protein namesi | Recommended name: Lipid phosphate phosphohydrolase 1ARBA annotation (EC:3.1.3.106ARBA annotation, EC:3.1.3.4ARBA annotation, EC:3.1.3.81ARBA annotation)Alternative name(s): PAP2-alphaARBA annotation Phosphatidate phosphohydrolase type 2aARBA annotation Phosphatidic acid phosphatase 2aARBA annotation Phospholipid phosphatase 1ARBA annotation |
Gene namesi | Name:PPAP2AImported ORF Names:hCG_39580Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000067113.16 |
Subcellular locationi
Plasma membrane
- Apical cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane raft ARBA annotation; Multi-pass membrane protein ARBA annotation
- caveola ARBA annotation; Multi-pass membrane protein ARBA annotation
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- caveola Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 54 – 73 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 94 – 112 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 197 – 216 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 228 – 250 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000067113, Expressed in prostate gland and 243 other tissues |
ExpressionAtlasi | A0A024QZS3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 102 – 243 | acidPPcInterPro annotationAdd BLAST | 142 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 260 – 284 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 269 – 284 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the PA-phosphatase related phosphoesterase family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_021458_3_1_1 |
PhylomeDBi | A0A024QZS3 |
Family and domain databases
InterProi | View protein in InterPro IPR028670, LPP1 IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase IPR043216, PLPP |
PANTHERi | PTHR10165, PTHR10165, 1 hit PTHR10165:SF26, PTHR10165:SF26, 1 hit |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024QZS3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFDKTRLPYV ALDVLCVLLA GLPFAILTSR HTPFQRGVFC NDESIKYPYK
60 70 80 90 100
EDTIPYALLG GIIIPFSIIV IILGETLSVY CNLLHSNSFI RNNYIATIYK
110 120 130 140 150
AIGTFLFGAA ASQSLTDIAK YSIGRLRPHF LDVCDPDWSK INCSDGYIEY
160 170 180 190 200
YICRGNAERV KEGRLSFYSG HSSFSMYCML FVALYLQARM KGDWARLLRP
210 220 230 240 250
TLQFGLVAVS IYVGLSRVSD YKHHWSDVLT GLIQGALVAI LVAVYVSDFF
260 270 280
KERTSFKERK EEDSHTTLHE TPTTGNHYPS NHQP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471123 Genomic DNA Translation: EAW54921.1 |
RefSeqi | NP_003702.2, NM_003711.3 |
Genome annotation databases
GeneIDi | 8611 |
KEGGi | hsa:8611 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471123 Genomic DNA Translation: EAW54921.1 |
RefSeqi | NP_003702.2, NM_003711.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 11159, 176 antibodies |
Genome annotation databases
GeneIDi | 8611 |
KEGGi | hsa:8611 |
Organism-specific databases
CTDi | 8611 |
VEuPathDBi | HostDB:ENSG00000067113.16 |
Phylogenomic databases
HOGENOMi | CLU_021458_3_1_1 |
PhylomeDBi | A0A024QZS3 |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
Miscellaneous databases
BioGRID-ORCSi | 8611, 14 hits in 870 CRISPR screens |
ChiTaRSi | PLPP1, human |
GenomeRNAii | 8611 |
Gene expression databases
Bgeei | ENSG00000067113, Expressed in prostate gland and 243 other tissues |
ExpressionAtlasi | A0A024QZS3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR028670, LPP1 IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase IPR043216, PLPP |
PANTHERi | PTHR10165, PTHR10165, 1 hit PTHR10165:SF26, PTHR10165:SF26, 1 hit |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024QZS3_HUMAN | |
Accessioni | A0A024QZS3Primary (citable) accession number: A0A024QZS3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |