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Entry version 29 (16 Oct 2019)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Cadherin-like 23, isoform CRA_a

Gene

CDH23

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cadherin-like 23, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDH23Imported
ORF Names:hCG_2024684Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1494 – 1517HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A024QZL8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 59CAInterPro annotationAdd BLAST59
Domaini84 – 169CAInterPro annotationAdd BLAST86
Domaini193 – 276CAInterPro annotationAdd BLAST84
Domaini300 – 384CAInterPro annotationAdd BLAST85
Domaini412 – 494CAInterPro annotationAdd BLAST83
Domaini518 – 599CAInterPro annotationAdd BLAST82
Domaini623 – 718CAInterPro annotationAdd BLAST96
Domaini745 – 827CAInterPro annotationAdd BLAST83
Domaini851 – 934CAInterPro annotationAdd BLAST84
Domaini958 – 1036CAInterPro annotationAdd BLAST79
Domaini1062 – 1147CAInterPro annotationAdd BLAST86
Domaini1178 – 1271CAInterPro annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
ENOG410XPEI LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR033030 CDH23

The PANTHER Classification System

More...
PANTHERi
PTHR24025:SF18 PTHR24025:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 10 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 13 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024QZL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFRMDRISG EIATRPAPPD RERQSFYHLV ATVEDEGTPT LSATTHVYVT
60 70 80 90 100
IVDENDNAPM FQQPHYEVLL DEGPDTLNTS LITIQALDLD EGPNGTVTYA
110 120 130 140 150
IVAGNIVNTF RIDRHMGVIT AAKELDYEIS HGRYTLIVTA TDQCPILSHR
160 170 180 190 200
LTSTTTVLVN VNDINDNVPT FPRDYEGPFE VTEGQPGPRV WTFLAHDRDS
210 220 230 240 250
GPNGQVEYSI MDGDPLGEFV ISPVEGVLRV RKDVELDRET IAFYNLTICA
260 270 280 290 300
RDRGMPPLSS TMLVGIRVLD INDNDPVLLN LPMNITISEN SPVSSFVAHV
310 320 330 340 350
LASDADSGCN ARLTFNITAG NRERAFFINA TTGIVTVNRP LDRERIPEYK
360 370 380 390 400
LTISVKDNPE NPRIARRDYD LLLIFLSDEN DNHPLFTKST YQAEVMENSP
410 420 430 440 450
AGTPLTVLNG PILALDADQD IYAVVTYQLL GAQSGLFDIN SSTGVVTVRS
460 470 480 490 500
GVIIDREAFS PPILELLLLA KDIGLLNSTA HLLITILDDN DNRPTFSPAT
510 520 530 540 550
LTVHLLENCP PGFSVLQVTA TDEDSGLNGE LVYRIEAGAQ DRFLIHLVTG
560 570 580 590 600
VIRVGNATID REEQESYRLT VVATDRGTVP LSGTAIVTIL IDDINDSRPE
610 620 630 640 650
FLNPIQTVSV LESAEPGTVI ANITAIDHDL NPKLEYHIVG IVAKDDTDRL
660 670 680 690 700
VPNQEDAFAV NINTGSVMVK SPMNRELVAT YEVTLSVIDN ASDLPERSVS
710 720 730 740 750
VPNAKLTVNV LDVNDNTPQF KPFGITYYME RILEGATPGT TLIAVAAVDP
760 770 780 790 800
DKGLNGLVTY TLLDLVPPGY VQLEDSSAGK VIANQTVDYE EVHWLNFTVR
810 820 830 840 850
ASDNGSPPRA AEIPVYLEIV DINDNNPIFD QPSYQEAVFE DVPVGTIILT
860 870 880 890 900
VTATDADSGN FALIEYSLGD GESKFAINPT TGDIYVLSSL DREKKDHYIL
910 920 930 940 950
TALAKDNPGD VASNRRENSV QVVIQVLDVN DCRPQFSKPQ FSTSVYENEP
960 970 980 990 1000
AGTSVITMMA TDQDEGPNGE LTYSLEGPGV EAFHVDMDSG LVTTQRPLQS
1010 1020 1030 1040 1050
YEKFSLTVVA TDGGEPPLWG TTMLLVEVID VNDNRPVFVR PPNGTILHIR
1060 1070 1080 1090 1100
EEIPLRSNVY EVYATDKDEG LNGAVRYSFL KTAGNRDWEF FIIDPISGLI
1110 1120 1130 1140 1150
QTAQRLDRES QAVYSLILVA SDLGQPVPYE TMQPLQVALE DIDDNEPLFV
1160 1170 1180 1190 1200
RPPKGSPQYQ LLTVPEHSPR GTLVGNVTGA VDADEGPNAI VYYFIAAGNE
1210 1220 1230 1240 1250
EKNFHLQPDG CLLVLRDLDR EREAIFSFIV KASSNRSWTP PRGPSPTLDL
1260 1270 1280 1290 1300
VADLTLQEVR VVLEDINDQP PRFTKAEYTA GVATDAKVGS ELIQVLALDA
1310 1320 1330 1340 1350
DIGNNSLVFY SILAIHYFRA LANDSEDVGQ VFTMGSMDGI LRTFDLFMAY
1360 1370 1380 1390 1400
SPGYFVVDIV ARDLAGHNDT AIIGIYILRD DQRVKIVINE IPDRVRGFEE
1410 1420 1430 1440 1450
EFIHLLSNIT GAIVNTDNVQ FHVDKKGRVN FAQTELLIHV VNRDTNRILD
1460 1470 1480 1490 1500
VDRVIQMIDE NKEQLRNLFR NYNVLDVQPA ISVRLPDDMS ALQMAIIVLA
1510 1520 1530 1540 1550
ILLFLAAMLF VLMNWYYRTV HKRKLKAIVA GSAGNRGFID IMDMPNTNKY
1560 1570 1580 1590 1600
SFDGANPVWL DPFCRNLELA AQAEHEDDLP ENLSEIADLW NSPTRTHGTF
1610 1620 1630 1640 1650
GREPAAVKPD DDRYLRAAIQ EYDNIAKLGQ IIREGPIKGS LLKVVLEDYL
1660 1670 1680 1690 1700
RLKKLFAQRM VQKASSCHSS ISELIQTELD EEPGDHSPGQ GSLRFRHKPP
1710 1720 1730 1740 1750
VELKGPDGIH VVHGSTGTLL ATDLNSLPEE DQKGLGRSLE TLTAAEATAF
1760 1770 1780
ERNARTESAK STPLHKLRDV IMETPLEITE L
Length:1,781
Mass (Da):196,635
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DF0ABE5072E0C12
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471083 Genomic DNA Translation: EAW54426.1
CH471083 Genomic DNA Translation: EAW54427.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471083 Genomic DNA Translation: EAW54426.1
CH471083 Genomic DNA Translation: EAW54427.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A024QZL8

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CDH23 human

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR033030 CDH23
PANTHERiPTHR24025:SF18 PTHR24025:SF18, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 10 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 12 hits
SUPFAMiSSF49313 SSF49313, 13 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024QZL8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024QZL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 16, 2019
This is version 29 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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