UniProtKB - A0A024QYW7 (A0A024QYW7_HUMAN)
Protein
Serine/threonine-protein kinase
Gene
PIM2
Organism
Homo sapiens (Human)
Status
Functioni
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.UniRule annotation
Catalytic activityi
- EC:2.7.11.1ARBA annotation
- ATP + L-threonyl-[protein] = ADP + H+ + O-phospho-L-threonyl-[protein]UniRule annotationARBA annotationEC:2.7.11.1UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 61 | ATPUniRule annotation | 1 | |
Binding sitei | 117 | ATP; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 124 | ATPUniRule annotation | 1 | |
Active sitei | 163 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 38 – 46 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PIM2Imported ORF Names:hCG_19826Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000102096.9 |
Subcellular locationi
Other locations
- cytoplasm Source: UniProtKB-UniRule
Expressioni
Gene expression databases
Bgeei | ENSG00000102096, Expressed in lymph node and 163 other tissues |
ExpressionAtlasi | A0A024QYW7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 286 | Protein kinaseInterPro annotationAdd BLAST | 255 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Pro-richSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.UniRule annotationARBA annotation
Phylogenomic databases
OMAi | QWARLPG |
OrthoDBi | 930292at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR017348, PIM1/2/3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF037993, STPK_Pim-1, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024QYW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTKPLQGPP APPGTPTPPP GGKDREAFEA EYRLGPLLGK GGFGTVFAGH
60 70 80 90 100
RLTDRLQVAI KVIPRNRVLG WSPLSDSVTC PLEVALLWKV GAGGGHPGVI
110 120 130 140 150
RLLDWFETQE GFMLVLERPL PAQDLFDYIT EKGPLGEGPS RCFFGQVVAA
160 170 180 190 200
IQHCHSRGVV HRDIKDENIL IDLRRGCAKL IDFGSGALLH DEPYTDFDGT
210 220 230 240 250
RVYSPPEWIS RHQYHALPAT VWSLGILLYD MVCGDIPFER DQEILEAELH
260 270 280 290 300
FPAHVSPDCC ALIRRCLAPK PSSRPSLEEI LLDPWMQTPA EDVPLNPSKG
310
GPAPLAWSLL P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471224 Genomic DNA Translation: EAW50729.1 CH471224 Genomic DNA Translation: EAW50730.1 |
RefSeqi | NP_006866.2, NM_006875.3 |
Genome annotation databases
GeneIDi | 11040 |
KEGGi | hsa:11040 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471224 Genomic DNA Translation: EAW50729.1 CH471224 Genomic DNA Translation: EAW50730.1 |
RefSeqi | NP_006866.2, NM_006875.3 |
3D structure databases
SMRi | A0A024QYW7 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024QYW7 |
Protocols and materials databases
Antibodypediai | 415, 444 antibodies |
Genome annotation databases
GeneIDi | 11040 |
KEGGi | hsa:11040 |
Organism-specific databases
CTDi | 11040 |
VEuPathDBi | HostDB:ENSG00000102096.9 |
Phylogenomic databases
OMAi | QWARLPG |
OrthoDBi | 930292at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11040, 16 hits in 530 CRISPR screens |
ChiTaRSi | PIM2, human |
GenomeRNAii | 11040 |
Gene expression databases
Bgeei | ENSG00000102096, Expressed in lymph node and 163 other tissues |
ExpressionAtlasi | A0A024QYW7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR017348, PIM1/2/3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF037993, STPK_Pim-1, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024QYW7_HUMAN | |
Accessioni | A0A024QYW7Primary (citable) accession number: A0A024QYW7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |