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Protein

L-fucose isomerase

Gene

fucI

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotationSAAS annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotationSAAS annotation

Cofactori

Mn2+UniRule annotationSAAS annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI_2), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI_1), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI), L-fucose isomerase (fucI)
  2. L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK_2), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK_1), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK_1), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK), L-fuculokinase (fucK)
  3. L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA_1), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA_2), L-fuculose phosphate aldolase (fucA_1), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA_3), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (mtnB), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA)
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei337Proton acceptorUniRule annotation1
Metal bindingi337ManganeseUniRule annotation1
Active sitei361Proton acceptorUniRule annotation1
Metal bindingi361ManganeseUniRule annotation1
Metal bindingi528ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processCarbohydrate metabolism, Fucose metabolismUniRule annotationSAAS annotation
LigandManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotationSAAS annotation (EC:5.3.1.25UniRule annotationSAAS annotation)
Short name:
FucIaseUniRule annotation
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
Gene namesi
Name:fucIUniRule annotationImported
ORF Names:A8C65_06150Imported, A9R57_06850Imported, AC789_1c31240Imported, ACN81_20270Imported, ACU57_24300Imported, AKG99_03670Imported, AM266_20270Imported, AML35_05185Imported, AW059_10785Imported, B1K96_19940Imported, B7C53_10165Imported, BHS81_16750Imported, BHS87_15845Imported, BIU72_09630Imported, BJJ90_05150Imported, BK248_13085Imported, BK383_11795Imported, BMR14_22595Imported, BUE81_06860Imported, CHQ87_0005515Imported, CR538_05385Imported, CR539_18925Imported, CRT55_05910Imported, CV83915_03316Imported, EC3234A_48c01110Imported, EL75_0891Imported, EL79_0893Imported, EL80_0896Imported, ERS085365_02450Imported, ERS085366_03063Imported, ERS085416_02921Imported, ERS139211_02049Imported, GJ11_18140Imported, PGD_04302Imported, RK56_023275Imported, RX35_01679Imported, SK85_03046Imported, WR15_06205Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000184168 Componenti: Unassembled WGS sequence
  • UP000044893 Componenti: Unassembled WGS sequence
  • UP000236496 Componenti: Unassembled WGS sequence
  • UP000215493 Componenti: Unassembled WGS sequence
  • UP000193530 Componenti: Unassembled WGS sequence
  • UP000030018 Componenti: Unassembled WGS sequence
  • UP000030000 Componenti: Unassembled WGS sequence
  • UP000194247 Componenti: Unassembled WGS sequence
  • UP000197917 Componenti: Unassembled WGS sequence
  • UP000037564 Componenti: Unassembled WGS sequence
  • UP000234543 Componenti: Chromosome
  • UP000236551 Componenti: Chromosome
  • UP000184277 Componenti: Unassembled WGS sequence
  • UP000215625 Componenti: Unassembled WGS sequence
  • UP000194285 Componenti: Unassembled WGS sequence
  • UP000040934 Componenti: Unassembled WGS sequence
  • UP000193168 Componenti: Unassembled WGS sequence
  • UP000234238 Componenti: Chromosome
  • UP000185422 Componenti: Chromosome
  • UP000224281 Componenti: Unassembled WGS sequence
  • UP000036012 Componenti: Unassembled WGS sequence
  • UP000051850 Componenti: Unassembled WGS sequence
  • UP000076106 Componenti: Unassembled WGS sequence
  • UP000216366 Componenti: Unassembled WGS sequence
  • UP000092566 Componenti: Chromosome
  • UP000186204 Componenti: Unassembled WGS sequence
  • UP000235136 Componenti: Chromosome
  • UP000050556 Componenti: Unassembled WGS sequence
  • UP000036728 Componenti: Unassembled WGS sequence
  • UP000031522 Componenti: Chromosome
  • UP000196822 Componenti: Unassembled WGS sequence
  • UP000029988 Componenti: Unassembled WGS sequence
  • UP000095183 Componenti: Unassembled WGS sequence
  • UP000077380 Componenti: Unassembled WGS sequence
  • UP000041959 Componenti: Unassembled WGS sequence
  • UP000186275 Componenti: Unassembled WGS sequence
  • UP000045242 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 174Fucose_iso_N1InterPro annotationAdd BLAST168
Domaini175 – 354Fucose_iso_N2InterPro annotationAdd BLAST180
Domaini390 – 554Fucose_iso_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105EHF Bacteria
COG2407 LUCA

Family and domain databases

Gene3Di3.20.14.10, 1 hit
3.40.275.10, 1 hit
3.40.50.1070, 1 hit
HAMAPiMF_01254 Fucose_iso, 1 hit
InterProiView protein in InterPro
IPR004216 Fuc/Ara_isomerase_C
IPR038393 Fuc_iso_dom3_sf
IPR015888 Fuc_isomerase_C
IPR038391 Fucose_iso_dom1_sf
IPR012888 Fucose_iso_N1
IPR005763 Fucose_isomerase
IPR038392 Fucose_isomerase_dom2_sf
IPR009015 Fucose_isomerase_N/cen_sf
IPR012889 Fucose_isomerase_N2
PfamiView protein in Pfam
PF02952 Fucose_iso_C, 1 hit
PF07881 Fucose_iso_N1, 1 hit
PF07882 Fucose_iso_N2, 1 hit
SUPFAMiSSF50443 SSF50443, 1 hit
SSF53743 SSF53743, 1 hit
TIGRFAMsiTIGR01089 fucI, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024LB23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKISLPKIG IRPVIDGRRM GVRESLEEQT MNMAKATAAL LTEKLRHACG
60 70 80 90 100
AAVECVISDT CIAGMAEAAA CEEKFSSQNV GLTITVTPCW CYGSETIDMD
110 120 130 140 150
PTRPKAIWGF NGTERPGAVY LAAALAAHSQ KGIPAFSIYG HDVQDADDTS
160 170 180 190 200
IPADVEEKLL RFARAGLAVA SMKGKSYLSL GGVSMGIAGS IVDHNFFESW
210 220 230 240 250
LGMKVQAVDM TELRRRIDQK IYDEAELEMA LAWADKNFRY GEDENNKQYQ
260 270 280 290 300
RNAEQSRAVL RESLLMAMCI RDMMQGNSKL ADIGRVEESL GYNAIAAGFQ
310 320 330 340 350
GQRHWTDQYP NGDTAEAILN SSFDWNGVRE PFVVATENDS LNGVAMLMGH
360 370 380 390 400
QLTGTAQVFA DVRTYWSPEA IERVTGHKLD GLAEHGIIHL INSGSAALDG
410 420 430 440 450
SCKQRDSEGN PTMKPHWEIS QQEADACLAA TEWCPAIHEY FRGGGYSSRF
460 470 480 490 500
LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS VELPKDVHDI LNKRTNSTWP
510 520 530 540 550
TTWFAPRLTG KGPFTDVYSV MANWGANHGV LTIGHVGADF ITLASMLRIP
560 570 580 590
VCMHNVEETK VYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R
Length:591
Mass (Da):64,977
Last modified:July 9, 2014 - v1
Checksum:iE6245DEEDF34EF9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP010315 Genomic DNA Translation: AJE57339.1
CP015229 Genomic DNA Translation: ANO90608.1
CP017631 Genomic DNA Translation: APT01450.1
CP024978 Genomic DNA Translation: ATZ33611.1
CP024147 Genomic DNA Translation: AUJ97240.1
CP024141 Genomic DNA Translation: AUJ99890.1
CP024056 Genomic DNA Translation: AUL83670.1
HG976963 Genomic DNA Translation: CDU41299.1
CYAQ01000019 Genomic DNA Translation: CTS75609.1
CYAV01000035 Genomic DNA Translation: CTT28271.1
CYDH01000018 Genomic DNA Translation: CTV90609.1
CYCX01000022 Genomic DNA Translation: CTW25517.1
JPKH01000006 Genomic DNA Translation: KGM71235.1
JPKL01000016 Genomic DNA Translation: KGM83200.1
JPMZ01000005 Genomic DNA Translation: KGM84759.1
LEUM01000018 Genomic DNA Translation: KLX95504.1
LGZN01000018 Genomic DNA Translation: KNF70830.1
LHAT01000009 Genomic DNA Translation: KOA00561.1
LDYI01000161 Genomic DNA Translation: KPO04831.1
LIVE01000042 Genomic DNA Translation: KQJ12959.1
LOGT01000057 Genomic DNA Translation: KYS97920.1
LCVH01000048 Genomic DNA Translation: OAC43304.1
LZEH01000101 Genomic DNA Translation: OEI65668.1
MOFD01000023 Genomic DNA Translation: OJK74962.1
MOKI01000024 Genomic DNA Translation: OJR54752.1
LGMY01000210 Genomic DNA Translation: OKU18479.1
MSEK01000046 Genomic DNA Translation: OLR88142.1
NAHY01000256 Genomic DNA Translation: ORJ75850.1
NAFT01000058 Genomic DNA Translation: ORT01720.1
NEME01000005 Genomic DNA Translation: OTB39619.1
NBCM01000023 Genomic DNA Translation: OTE91481.1
LYBG01000431 Genomic DNA Translation: OWD73827.1
NBSF01000015 Genomic DNA Translation: OWS85739.1
LEOO01000007 Genomic DNA Translation: OYC71230.1
MVPO01000017 Genomic DNA Translation: PAR04386.1
MOXW01000069 Genomic DNA Translation: PGG43296.1
JWSO02000016 Genomic DNA Translation: PNO94859.1
NOLW03000012 Genomic DNA Translation: PSM35995.1
RefSeqiWP_000724153.1, NZ_PUEB01000014.1

Genome annotation databases

EnsemblBacteriaiAJE57339; AJE57339; AC789_1c31240
ALZ65979; ALZ65979; AWH59_07360
ANM83541; ANM83541; A8V37_13960
ANO90608; ANO90608; GJ11_18140
AOT31522; AOT31522; FORC31_1057
CDU41299; CDU41299; PGD_04302
CTS75609; CTS75609; ERS085365_02450
CTT28271; CTT28271; ERS085366_03063
CTV90609; CTV90609; ERS139211_02049
CTW25517; CTW25517; ERS085416_02921
CTW94191; CTW94191; ERS139235_00235
KGM71235; KGM71235; EL75_0891
KGM83200; KGM83200; EL80_0896
KGM84759; KGM84759; EL79_0893
KHH09297; KHH09297; PU69_10720
KHI37487; KHI37487; PU33_02460
KIH34834; KIH34834; PD07_17690
KIQ46159; KIQ46159; IY32_12280
KLG77881; KLG77881; WR12_09830
KLX95504; KLX95504; SK85_03046
KNF70830; KNF70830; WR15_06205
KOA00561; KOA00561; AKG99_03670
KPO04831; KPO04831; ACU57_24300
KQJ12959; KQJ12959; AM266_20270
KXQ40764; KXQ40764; AUQ01_08300
KYS97920; KYS97920; AML35_05185
OAC43304; OAC43304; EC3234A_48c01110
OAF45110; OAF45110; AXK33_08590
OAO69605; OAO69605; OO96_08985
OCO58785; OCO58785; AN669_0210215
ODA88683; ODA88683; A9D65_02160
ODH32132; ODH32132; A6803_04535
OEI65668; OEI65668; A9R57_06850
PATRICifig|562.10472.peg.2792

Similar proteinsi

Entry informationi

Entry nameiA0A024LB23_ECOLX
AccessioniPrimary (citable) accession number: A0A024LB23
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 20, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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