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Entry version 22 (11 Dec 2019)
Sequence version 1 (09 Jul 2014)
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Protein

Nonribosomal peptide synthetase vlms

Gene

vlmS

Organism
Lecanicillium sp.
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of verlamelin, a lipopeptide that exhibits antifungal activity against plant pathogenic fungi (PubMed:24848421).

Verlamelin is a cyclic hexadepsipeptide and is bridged by ester bonding between a 5-hydroxytetradecanoic acid moiety and a carboxyl group on the terminal Val of amide-bonded tetradecanoyl-hexapeptide D-allo-Thr-D-Ala-L-Pro-L-Gln-D-Tyr-L-Val (PubMed:24848421).

VlmA and vlmB are altogether regarded as essential components in the biosynthesis of 5-hydroxytetradecanoic acid (PubMed:24848421).

VlmA catalyzes the hydroxylation at position C5 of tetradecanoic acid produced in primary metabolism, while the precise function of vlmB still remains to be solved (PubMed:24848421).

To be loaded onto the waiting NRPS, 5-hydroxytetradecanoic acid is activated in the form of acyladenylate by the AMP-dependent ligase vlmC (PubMed:24848421).

VlmS seems to accept the fatty-acyl intermediate onto the initial module to further elongate amino acid residues by the downstream modules (PubMed:24848421).

In addition, in the last module at its C-terminus, vlmS contains a surplus condensation (C) domain that may be involved in cyclization, the last step to form verlamelin (PubMed:24848421).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase
Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthetase vlms1 Publication (EC:6.3.2.-1 Publication)
Short name:
NRPS vlmS1 Publication
Alternative name(s):
Verlamelin biosynthesis protein S1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vlmS1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLecanicillium sp.
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1756136 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesCordycipitaceaeLecanicilliumunclassified Lecanicillium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to complete loss of verlamelin production (PubMed:24848421).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004385791 – 8903Nonribosomal peptide synthetase vlmsAdd BLAST8903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1561O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3121O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4686O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei5790O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei6873O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei8405O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A024F910

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 84Carrier 1PROSITE-ProRule annotationAdd BLAST74
Domaini1524 – 1600Carrier 2PROSITE-ProRule annotationAdd BLAST77
Domaini3084 – 3160Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini4649 – 4725Carrier 4PROSITE-ProRule annotationAdd BLAST77
Domaini5753 – 5829Carrier 5PROSITE-ProRule annotationAdd BLAST77
Domaini6836 – 6912Carrier 6PROSITE-ProRule annotationAdd BLAST77
Domaini8368 – 8444Carrier 7PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni13 – 81Thiolation (T) domain 1Sequence analysis1 PublicationAdd BLAST69
Regioni59 – 736Adenylation (A) domain 7Sequence analysis1 PublicationAdd BLAST678
Regioni572 – 953Condensation (C) domain 1Sequence analysis1 PublicationAdd BLAST382
Regioni989 – 1386Adenylation (A) domain 1Sequence analysis1 PublicationAdd BLAST398
Regioni1529 – 1597Thiolation (T) domain 2Sequence analysis1 PublicationAdd BLAST69
Regioni1613 – 2050Epimerase (E) domain 1Sequence analysis1 PublicationAdd BLAST438
Regioni2091 – 2523Condensation (C) domain 2Sequence analysis1 PublicationAdd BLAST433
Regioni2546 – 2943Adenylation (A) domain 2Sequence analysis1 PublicationAdd BLAST398
Regioni3089 – 3157Thiolation (T) domain 3Sequence analysis1 PublicationAdd BLAST69
Regioni3174 – 3614Epimerase (E) domain 2Sequence analysis1 PublicationAdd BLAST441
Regioni3655 – 4093Condensation (C) domain 3Sequence analysis1 PublicationAdd BLAST439
Regioni4114 – 4512Adenylation (A) domain 3Sequence analysis1 PublicationAdd BLAST399
Regioni4654 – 4722Thiolation (T) domain 4Sequence analysis1 PublicationAdd BLAST69
Regioni4775 – 5191Condensation (C) domain 4Sequence analysis1 PublicationAdd BLAST417
Regioni5216 – 5614Adenylation (A) domain 4Sequence analysis1 PublicationAdd BLAST399
Regioni5758 – 5826Thiolation (T) domain 5Sequence analysis1 PublicationAdd BLAST69
Regioni5875Condensation (C) domain 5Sequence analysis1 Publication1
Regioni6311 – 6702Adenylation (A) domain 5Sequence analysis1 PublicationAdd BLAST392
Regioni6841 – 6909Thiolation (T) domain 6Sequence analysis1 PublicationAdd BLAST69
Regioni6923 – 7349Epimerase (E) domain 3Sequence analysis1 PublicationAdd BLAST427
Regioni7391 – 7823Condensation (C) domain 6Sequence analysis1 PublicationAdd BLAST433
Regioni7844 – 8240Adenylation (A) domain 6Sequence analysis1 PublicationAdd BLAST397
Regioni8369 – 8441Thiolation (T) domain 7Sequence analysis1 PublicationAdd BLAST73
Regioni8482 – 8897Condensation (C) domain 7Sequence analysis1 PublicationAdd BLAST416

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (PubMed:24848421). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for l- to d-amino acid conversion) are present within the NRP synthetase. VlmS has the following 7 module architecture: T-E-C-A-T-E-C-A-T-E-C-A-T-C-A-T-C-A-T-E-C-A-T-C (PubMed:24848421). The epimerase domain in the first module is probably non-functional (PubMed:24848421).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 7 hits
3.30.559.10, 10 hits
3.40.50.12780, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 6 hits
PF00668, Condensation, 10 hits
PF00550, PP-binding, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 7 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 6 hits
PS50075, CARRIER, 7 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024F910-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAPDIQAPS GSCRTTLGKV AADIFEMNVE TLDWDMSFIQ MGGDSILAID
60 70 80 90 100
FIVRCRDEGI WVDMMDLLTV DTLAELADSI DEQNGVTADV ANSSDLNEHE
110 120 130 140 150
THQENGENIN ATLPVADRPL RFASMEIAHV KDASLVSSAL ESLITRHSAL
160 170 180 190 200
RSVWSVSSTG EYTLTTKPTA MAYESQPFFL AEASEPTKMN DAFELLKNAL
210 220 230 240 250
RSDGAPPLGC LFISNNATTA SSIIVLAADA NLVDSLSMRI LRTEFREFIL
260 270 280 290 300
GHALDAPPGF QFSNWVAAKC QSTTARPRTL QQPQRAMERA IATKLSSSTS
310 320 330 340 350
SADSSSNEAT ITTFQITHST TKKLFAAQTH AALRTIPAEI INAALVYVLG
360 370 380 390 400
AHYKKNVDHL MIKTAYSVRE QQNLPLDAVG CYEAEIEWEA PALSSHESAV
410 420 430 440 450
FAVRRVCDAF ATPSRNSYDT STETLYIDCT RLQDTEDDEL SSFSDTILGH
460 470 480 490 500
GHHVSVATVA GQVHVSMQLG NEKISRESIT NEFKLCLEKM LDELAQSPEM
510 520 530 540 550
ATLRDYPLIH WSYSDLDDLV ADLKSQIVTI KGIESIGPSS AVQESFFISQ
560 570 580 590 600
AINPDSYINH VKVRMASADD SVPHQLDTEK LVYAWGNIVK RHAVLRTAFV
610 620 630 640 650
ESRDRPGKYD QLVFNPIAVL PRVTVFSCTP EASNTPSFQT GKFEVPMRLC
660 670 680 690 700
VYEISTSELQ LELDISHALV DGHSAKILLH DLRASYLQDT YFSELAPLPY
710 720 730 740 750
TDFAFHQQTV LDAGETSDGV AYWTSYMNKA GESHLPLITT NPNLKNLETA
760 770 780 790 800
HRTISLPAGK LRAICGQLSI TPANLFHIAW ALALRRIILT DTITFSYIVS
810 820 830 840 850
GRNGSLENSE ATVGPFINTL PFSLALAPET SVTEVLDLSK RDWQEGASFH
860 870 880 890 900
NVPISELAVS KTRSLKRLGN TLLSIEREGS SSHPFADGSD LSLSARTSAT
910 920 930 940 950
DFDLTANIRF DEERIEFSVE YWASRIAWPV AKAQMSAFED AVSFLLDGVN
960 970 980 990 1000
MSIRDFPTHG IQDKMAFLEW NTAPARLESC VHDLVLEKMA AQPTALAISA
1010 1020 1030 1040 1050
WDGEMTYGQL DHASYRVACE LVEFGITPDT MVGMCMEKSK LGVVAMLGIL
1060 1070 1080 1090 1100
RAGGAVVPLG VQHPIARIKG IVADAQIPLI LVDEAHKERL AELEPAAKLF
1110 1120 1130 1140 1150
AVDSFVKNDK SSPSTASSPK PCTSVGPDHV AWVIYTSGST GAPKGVMLEH
1160 1170 1180 1190 1200
GALSTSILYH GRRLDIQSYD RLLQFAAFTF DAAIQEIITA FAFGASTCIP
1210 1220 1230 1240 1250
SEQERMDQLP AFISREKITI TTLTSTVAAL LHPQDVPTVR TMILMGEAVQ
1260 1270 1280 1290 1300
AKVVDQWIDH ATVINAYGPS ECCIHSTCRP VQSSLTALNI GTAIAGATWI
1310 1320 1330 1340 1350
ANPKNVGQLV PLGAPGELLL EGPLLARGYL NDPIKTAKAF VADPAFVAEL
1360 1370 1380 1390 1400
NLSPGRRFYR TGDLAQQNPD GTITYLGRID TQIKIRGQRV EIGEIEYHIG
1410 1420 1430 1440 1450
KQSGVHDAAV LYIREGPLAD RLVAAVNLGE STPNADQFQG SAIQCVTGDE
1460 1470 1480 1490 1500
KDKATLQLRE IQYALSQQVM HYMVPSVWIP LYAMPMNNSG KTDRRALTLW
1510 1520 1530 1540 1550
VQALSQSEID EITAAEADDD IDESSMSTVE QELRQIWSKV LDVPLRSVTY
1560 1570 1580 1590 1600
SANFFSLGGD SITAMQVVSA CRARGIIVTV RKVLDCQTIP QLALAAESQA
1610 1620 1630 1640 1650
TSANEEVVTE APFPLSPIQK MYFETVAADG LRADGETSFN QGVLLHVTRR
1660 1670 1680 1690 1700
VELAELTEAL NKTVAKHAML RARFFRTQNQ EFQQKIERDV TGSYRLRAHA
1710 1720 1730 1740 1750
DVANAESLHG IVAESQATLD LERGPIFAAD LIERQDRQVL HLVAHHLVID
1760 1770 1780 1790 1800
LVSWRILVQD LEEVIINKAL PNPRSMAFPT WIERQHNYLD KLMDRKTEVL
1810 1820 1830 1840 1850
PVTVPATSWS YWGLVPGEEV YANRTSYQVK CDSNVVDLLS GHANAALKTE
1860 1870 1880 1890 1900
PVEVLLAALV FSFQQAFPDR DVPAIFTEGH GRETIDAVSD PSDTIGWFTT
1910 1920 1930 1940 1950
MAPVYLPQRA SENAIIEVVK QVKDQRRRIP GRGMPYFGSR FSTTRCKSQF
1960 1970 1980 1990 2000
ASHSPAEIIF NYAGRFQQLE REDALFRFDS EDDMNTTSKI GGRVKLLSAL
2010 2020 2030 2040 2050
DVAATVEGNE LLITVNFSNQ SQHQDSIRSW VDAYGKCIES TVKELAAVSA
2060 2070 2080 2090 2100
PIATATDFPL AHLSDADMKT IETDSDYLAV IGCSSTAELD DILPCSPIQQ
2110 2120 2130 2140 2150
GILLTQLQSP STYCIHQTCR IRSTTTSPMD IERLIAAWKE IVSRHSILRT
2160 2170 2180 2190 2200
VLLEPLPGQE QFMQMVLKEP RIGIKRVNDI SDDIAAEWLE SQPTLDLSEL
2210 2220 2230 2240 2250
TRPPHLLTLL TTAKGEVYCR FDISHALVDA SSVSLIMQDL LSAYDGNLGP
2260 2270 2280 2290 2300
NVGSDYSSYV AYLEEQDSQD ELEYWTSVLR NAEPCILSPQ DPIHDNRADS
2310 2320 2330 2340 2350
TIKRVVAHID DLSPLYKFRD TYGVSLASIC QLSWALVLAM RTNSENISFG
2360 2370 2380 2390 2400
NLSSGRDVPI QNVQALVGPM INMLICRLSL DWDANASDVA RNLQRQVSES
2410 2420 2430 2440 2450
FEHQRSSLAS IQHALGLSRN QPLFNSTLSY KRADSDAAAS PATGIYLEGL
2460 2470 2480 2490 2500
AWDDPTEYDL HTNIETSKTG MEIHMQYSTA VFSDNAATKM IEGLTRAIQA
2510 2520 2530 2540 2550
VCVGGETPLS QLQLLSVSEE NKLRQWNAVA TPRLERCVHE LVLEKMSSHA
2560 2570 2580 2590 2600
DATAISAWDG SMTYQELNNA SIQLAHHLVA QGVRPEVKIG LCLDKSRLGV
2610 2620 2630 2640 2650
VAMLATLRAG GAVVPLGVQS PVARIETIVN DSEMKIVLVD RNNQERLNTL
2660 2670 2680 2690 2700
ASTVQLLAVD QFAQTMSTPT DILLKEPCSS VQPDNTAWII YTSGSTGIPK
2710 2720 2730 2740 2750
GVVLEHGSIA TSMRAHGPAI GIQPQDRVSQ FAAYTFDVSI AETMTTLAYG
2760 2770 2780 2790 2800
ACICIPSEDD RINRLTGFLS EHKVTIATLT STVASLVQSI DTPTIKTLVL
2810 2820 2830 2840 2850
TGEAVQPNVV DQWKQHNTTV INAYGPSESS IWATSKIVED SKDALNIGLP
2860 2870 2880 2890 2900
LSGAFWVVNR NNIGQLVPVG SPGELLIEGP LLARGYLNDQ IKTAASFVVD
2910 2920 2930 2940 2950
PAFIHDLGFT TGRRMYRTGD LVQQNDDGTM VYLGRQDSQV KIRGQRVEIG
2960 2970 2980 2990 3000
EIEYHVGKQE GVQDAAVLHM KDGPLADRLV AIVIPRNDDL KTTRGQNDAQ
3010 3020 3030 3040 3050
ITQIPQQFKE DTKRHLQGVK QKLSQLVMQY MVPNVWIPLV AMPVNMSGKM
3060 3070 3080 3090 3100
DRLALNRWIQ SLSKDELAFM TGTEETQDPD QDKLFTTAIE RQLRQVWSDV
3110 3120 3130 3140 3150
LGVSVHAVTY TSNFFSLGGD SITAMQVVSM SRSHGILVTV RTVLECQTIP
3160 3170 3180 3190 3200
ELALQAKMVD GDNSQLTRVP EGPFALSPIQ QMYFANISGD GIRADGNYRF
3210 3220 3230 3240 3250
NQAVSLYIST HISQEQLKHA LDAVVSKHAM LRARYSQGPA GWQQWIEKDV
3260 3270 3280 3290 3300
SGGFRCQSYD AVDLDAMRQI IETSQTSLDI EHGPVFAADL IERQDNDRQV
3310 3320 3330 3340 3350
LHLVAHHLSI DLVSWRIVIQ DLEQLLTNGK LPNPTTLSFP VWLERQQDSL
3360 3370 3380 3390 3400
DTFIAKMDTP ESALSQLLPT SVPVIDWNYW GLSPGQEVYG SLTSLETRCD
3410 3420 3430 3440 3450
SATTSLLLDQ ANSALKTEPV EILLAALLSS FQQVFTDRQS PAVFTEGHGR
3460 3470 3480 3490 3500
EAFDTKSELD LSETVGWFTT MTPVYIPQSA ATNSIQMLQK IKDQRRRVPG
3510 3520 3530 3540 3550
RGMPYFGSRY LTSAGEEKFA DHATPEILFN YFGRFQQFER DDALFQINND
3560 3570 3580 3590 3600
DDSASSQFGD LIKLFAALDV TVAVEASELH IKTRFSRQSQ HQASIQRWVQ
3610 3620 3630 3640 3650
AYGNAIKSLV EELMVTAATS TATDFPLARL TDTNWEFMQK QYLVAMNLQS
3660 3670 3680 3690 3700
TAEIEDILPC SPMQQGILLT QLQSPTTYCI HQISRFQPSK SGSVSVERLI
3710 3720 3730 3740 3750
SSWKHVVSRH SILRTILVEP LPGQERFVQI VLKQPHLDII KLREITDSEH
3760 3770 3780 3790 3800
AAIATLEAQP LLNARKITSP PHRITMLQST AGEVYCRFDI SHALIDGSSM
3810 3820 3830 3840 3850
AILIRDLMSA YSEDVSSDSI ASGSKYSSYV AYLEDTDHQK ADLQYWTSLL
3860 3870 3880 3890 3900
ADSEPCILPS EASAPESEPA QLGHVSKTIS DLDALHGFRD THNVSIASIC
3910 3920 3930 3940 3950
QLAWALVLST WTGSSDISFG NLSSGRDVPI EGVQDLVGPM INMLICHVPL
3960 3970 3980 3990 4000
DWNASVADVA RKIQSQSAEA FEHQRSSLAA IQHELGLSRD KPLFNTTLSY
4010 4020 4030 4040 4050
KRITPPPSSS GSTSITFEAL VQEDPTEHDL HVNIDSTPTG LQFDIQFSTA
4060 4070 4080 4090 4100
VFSSAAAETL TESLVRTVGI LSQSAHLSLG NVNLMSTKDI QQLCEWNSKM
4110 4120 4130 4140 4150
PSRTELCVHD LISERLNTQP ESMAISAWDG DMSYLELDAV SHTLASHLIT
4160 4170 4180 4190 4200
LGLDFQRSEP MIGLCMDKSK WAVVAMLAIL RAGGTVVPLG VQHPVSRIDN
4210 4220 4230 4240 4250
IVQDTSAIVV IVDRGQEQRL ASLGTSTHLL AIESFFEASP PVASQSTPLT
4260 4270 4280 4290 4300
ADTTPDSAAW VIYTSGSTGK PKGVVLEHGA LVTNILAHGR AMNIQPGDRV
4310 4320 4330 4340 4350
LQFAAYTFDI SIAEVLTTLI FGACVCVPSE SERMEQLACF ISRQEVTTAI
4360 4370 4380 4390 4400
LTSTVAALVD PQQTPTLQTL VLTGEAVQPK VVSQWIGQAT VMNCYGPSES
4410 4420 4430 4440 4450
WICTTHKIES AATASVVGPP IAGGFWVVNP GSVDQLVPIG APGELLIEGP
4460 4470 4480 4490 4500
LLAREYLNNA DKTAASFIND LAFTKELGLG SRRMYRTGDL VKYNSNGALV
4510 4520 4530 4540 4550
YIGRIDTQIK IRGQRVEIGE IENQIVDLLP GAREAVVDLI TPAEVEGASP
4560 4570 4580 4590 4600
MLVAVVEYRQ DEPRTDATGL SLYDPSQLTD ATLEALDQLQ TDIAKALPAY
4610 4620 4630 4640 4650
MIPATFLLAS KLPINASGKL DRRTLRLALQ DMTREELGNS TGNTSTKQAP
4660 4670 4680 4690 4700
RTTMEKKLRD LFAATLQLTP DNFGINDSFF RLGGDSVAAM KMTAAARALD
4710 4720 4730 4740 4750
LPLSVVDIFR FPILADLAEA TELKCSQQQE DSRSLVPFSL WPELQQDHAS
4760 4770 4780 4790 4800
SSDSYKTQLL AEAAQLCGVS ASQIEDVYPC SPLQAGLMAI TSQRPEAYIM
4810 4820 4830 4840 4850
RRAFKLRASF PIEQLKIAYE RLTEAVSILR TRIIPSTCVD ALQVVVQEKP
4860 4870 4880 4890 4900
FWHGEVGMSL EQYIAKDRSA SMAYGRALSR TAIVSNEDGQ FFVWTMHHSV
4910 4920 4930 4940 4950
YDGWSLTKMM GMLTQLMTGQ ALATTVPSSR FINYLVQQDT DQVAKFWQSH
4960 4970 4980 4990 5000
FQGANWTRFP ALPSPRYQAK SSGQLRSQFQ LPLNPSILET DSTVLRAAWA
5010 5020 5030 5040 5050
LLVASKIGAD EAVINVVLSG RMAPVEDIMN MLTPTVTTVP VRVSATKNQS
5060 5070 5080 5090 5100
INKFLKTIHD TAIDMVPFEH TGLQNIRTMV PTLGSDFDPG HTFVVQPAGE
5110 5120 5130 5140 5150
SESAATMWNM DLEREATPLD AFDAYALTVE CTVDSQRTGE VTVDIRYDSF
5160 5170 5180 5190 5200
VIPDDDAQKL LNQFTHIAQE LAQQAATTKP LAQLQMLSEE DRFLLSKWNA
5210 5220 5230 5240 5250
HVPPRLEYTL HDAVTETMTS QPDAPAIYSW DGDMTYGEVN AASHRLASHL
5260 5270 5280 5290 5300
ANQGVGPEVM VGLCMDKSKW AIVSMLAILR AGGAVVPLGI SHPLARIDNI
5310 5320 5330 5340 5350
IQDTAAPLVL VDSTHQHRLQ DLTAPTPLLA VDKFFEEYEA ANYDSSAKLP
5360 5370 5380 5390 5400
STVQPHHPAW VIYTSGSTGT PKGIVLEHRA LATSILSHGK EFGIQAHDRV
5410 5420 5430 5440 5450
LQFAAYTFDV AIQDVIATLA SGACLCVLSE YDRINRLTEF LSESNVSFAI
5460 5470 5480 5490 5500
LTPTVAALIE PKDVPTVKTL VLGGEALPAK VVDQWAEHAL IINGYGPSEC
5510 5520 5530 5540 5550
CIHSTCAKIP LGSDARNIGR GVTANTWVVD PTDIGQLVPI GSPGELLIEG
5560 5570 5580 5590 5600
PLLARGYLND PTKTAKSFIR DPAFLSTLNL PNGRRMYRTG DLVQQNRDGS
5610 5620 5630 5640 5650
LIYIGRRDTQ VKIRGQRVEI GEIESRIVDL LPEAREAVVN LVRPAGEAAD
5660 5670 5680 5690 5700
LVTLVAVIEC DYAAGASHDT ESELELFKPS SYSDALNRAL VKLDDDLGQA
5710 5720 5730 5740 5750
LPSYMVPSAY LLVPKLPLNP SGKLDRRAIQ DQLQLLPRAK INSLSGLTNR
5760 5770 5780 5790 5800
KQAPTTAMEK RLQNLFCQTL MLTPEEVGVN DSFFRIGGDS IAAMKLTAVA
5810 5820 5830 5840 5850
RHQNLPVSAA DIFRWPRLGD LAQELEQRHE LKTATLNDPA PLSLWPELSQ
5860 5870 5880 5890 5900
AGTQSKSQLL ANIASQCGVS VEAIEDVYPC SALQAGLMAI TTQRPEAYVV
5910 5920 5930 5940 5950
QRVFKLQPSL SSQHFKAAWN QLAQSLPILR TRIVPSIHTD ALQVVTRDAP
5960 5970 5980 5990 6000
VWQETQASVQ DYLENDRTVP IAYGTPLSRV AIVQDQQSRY FVWTIHHSAY
6010 6020 6030 6040 6050
DGWSMGKMME VLSQVLEGTT PSVLVPVSRF IGYLSQQDKS QTSTFWQKHF
6060 6070 6080 6090 6100
EGASCTVFPE LPSRQHVVNP NKTLKSRIQI SQSPGVTPFT ALRAAWALVV
6110 6120 6130 6140 6150
ASATGSDDAL INVVLSGRLA SVDGIMDLVA PTITTVPFHV PISQDLSVKE
6160 6170 6180 6190 6200
FLANVDERAS DMIPYEHTGL QHIRRMVPGL GPEFSPGHVF VVQPAAESES
6210 6220 6230 6240 6250
TVAALPQMEL IKSDFESEDA FHAQALTVEC TVGQDLSDVE VQMRYDGNVL
6260 6270 6280 6290 6300
STESATHLLD QFSHVVEQLA LNGDKSLSQL ELLTANDRQR LIEWNSTVPP
6310 6320 6330 6340 6350
RVERCIHQLV EEQMSLRPSE LAIKAWDGDM TYAELDTSSR QLAQRLTQMG
6360 6370 6380 6390 6400
VGPDVMVGIC MDKSKMGVVA ILAILRAGGA VVPLGVTHPL TRIEGIVKDT
6410 6420 6430 6440 6450
KSPLILVDSA QKQRLASLTA QLLVVDSTLT NTLTASAQNI SVQSKNVAWV
6460 6470 6480 6490 6500
VYTSGSTGTP KGVVLEHGAL ATSVLGHGAA YNVRSDDRIL QFAAYTFDAA
6510 6520 6530 6540 6550
IQEIITTLAF GACICVPSEQ DRVNRLTDFF IETGITMATL TSTVAGLVRP
6560 6570 6580 6590 6600
NMTPAVRTII LVGEAVQANV VDQWIQKATV INGYGPSECS IASTCGEIRH
6610 6620 6630 6640 6650
SSYALNIGTA IAGATWIVGS TNKLVPIGTP GELLLEGPLL ARGYLNDAVK
6660 6670 6680 6690 6700
TAASFTTNAA FVEELGLSSA NRRMYRTGDL VKQNIDGSIT YLGRMDGQIK
6710 6720 6730 6740 6750
IRGQRVEIGE IEHHLQKHSV VGDAVVLYMK QGPLSGRLIA IVVTNDTNST
6760 6770 6780 6790 6800
SQTAEIQHLP TGQRESANLE LTDVQQSLSN QLMQYMIPSV WIALASIPVN
6810 6820 6830 6840 6850
ISGKTDRLTL TRWLQSLSDD EVEALTGTEE TEVDESSATN TERQLRQIWS
6860 6870 6880 6890 6900
QVLDVPIEKI TFSSTFFSLG GDSITAMQVV SACRSCGLLV SVQKVLNCQT
6910 6920 6930 6940 6950
IPELAATLEV MDIVNDVDQI PEGFFELSPI QRMYFDDMAA MGLRADGENR
6960 6970 6980 6990 7000
FNQAVTLRIT RPTTSEELIQ ATDILVAKHP MLRARFIQNQ QSWQQHIEKE
7010 7020 7030 7040 7050
VAGSYRFELH EVADAQAMQS IITQSQASLN LEHGPVFAID LIDLPTKKVL
7060 7070 7080 7090 7100
HLVAHHLVID LVSWRVLAQN LEDLLTSGTE PNPTSLSFPS WIQKQFQFLP
7110 7120 7130 7140 7150
SSEETSESVL PVQIPASNWE YWGLVPGSER FGNRSKIEVK CDTSTTSLLT
7160 7170 7180 7190 7200
GDANYAFNTE PVEVLLAALA ISFQKTFTDR SMPAVFVEGH GRETMDDKVD
7210 7220 7230 7240 7250
LSDTVGWFTT MTPVHVPMDK NESDLDVLRR TKDQRRRIPG RGLPYFASRF
7260 7270 7280 7290 7300
LGPNPDKFDN HGPAEILFNY FGRFQQLERE NSVFQIEQDG ESAPQLGNSV
7310 7320 7330 7340 7350
KLFAALDLSI AIEGDQLSIT VHYSNKSKHQ STIRQWAESY GRTIKTLVEA
7360 7370 7380 7390 7400
LVIAPPTSTA TDFALARLSD SDMVAIEKDC VSNVGSTRNI EDILPCSPIQ
7410 7420 7430 7440 7450
QGILLSQLQS PTTYSIYQTC RIKPSKHDSL VDAHRFLGAW KQLVAHHSIL
7460 7470 7480 7490 7500
RTVLLEPLPG HEKFMQIVLR EPEINVLTKS GVADAEAVEW INSRPGLDLT
7510 7520 7530 7540 7550
DRHHPPHRLT LLTTTSGQVY CRFDISHALV DASSLALIIR DLMSAYEGKL
7560 7570 7580 7590 7600
GSSSNGSNYS AYIAYLDDNN QQDDLNYWTS LLNNAEPCLV PPKEPTHTAT
7610 7620 7630 7640 7650
QATIGHASQK VSDLDVLHKF RDTYGISIAS ICQLSWALVL ATWTGSQNVS
7660 7670 7680 7690 7700
FGNLSSGRDA PIPGAQDLVG PMINMLVCHL QLDWDSKVSD AARKIQTQSS
7710 7720 7730 7740 7750
EAFEHQRVSL ASIHHALGLS KDQPLFNSVM SYKRLATGES TPREIILEGL
7760 7770 7780 7790 7800
TAEDPSEYDV NVHINASSTS LDFNIQFSTT VLSQAAANKL TASLVQAVHA
7810 7820 7830 7840 7850
ITQNANRSLG QLKLVLTNDE AQICKWNSFM PAGLQNRVHD HVLEQMARKP
7860 7870 7880 7890 7900
EAQAIFASDG QMSYGELDVS SRQLAHHLVS QGVGPDVVVG VCMDKSRWAV
7910 7920 7930 7940 7950
VAMLSILRAG GAVAPLGVQH PVARIDTIVK DASAPVILVD AEQEQRLDTL
7960 7970 7980 7990 8000
SNNFQLINVK SFFDTVQNTV STSEPCTTVQ SHHIAWVLYT SGSTGVPKGV
8010 8020 8030 8040 8050
MLEHGSLATS IMLHSRRFAM QSTERLLQFA AFTFDAAVFD IFAPLSHGGC
8060 8070 8080 8090 8100
TCIPSEHDRM NNLEAFAIGA KVTWGFFTPT VAALMQPSDI PSMRTLILGG
8110 8120 8130 8140 8150
EVVTAKGVDH WVKAGVKVIN VYGPTECSIY STYKHIQDTQ NLRNIGTTVA
8160 8170 8180 8190 8200
AGLWVVNPVS GEQLVPIGAP GELLIEGPLL ARGYLNDSAK TAASFVTDPK
8210 8220 8230 8240 8250
FVKELGLSPG RRMYRTGDLV QQNSDGTLTY LDRIGTQVKI HGQRLEIGEI
8260 8270 8280 8290 8300
ESQLHDLLPE SRYVCVCKKG TSLVAVIEST TPNRDTPGTS AHYIVAPGPE
8310 8320 8330 8340 8350
QEKTFEYLNS TLREKLPSYM IPSAFLVINE FPLNDNGKFD RRRIGNLLNS
8360 8370 8380 8390 8400
IPSDKWLEYT AKSQTYYAPI SATEAVFCEL WSQCIQQLDK PVSRTDNFFD
8410 8420 8430 8440 8450
LGGDSVTAMQ LVQQLAKRGM RLATIDIFNN PVLHAMAACV SDVSDDNQEY
8460 8470 8480 8490 8500
KRFSLISTEE KSTALELVAA DDTVDKQIRV IDVLPTTEFQ TLMVRQIMSA
8510 8520 8530 8540 8550
ARRQLNQFAF DADEACDVSV LTSAISDLVA TIESLRAGFV KLPGQKYLQV
8560 8570 8580 8590 8600
VYAVWEPEIR VFYTEKSPRA FYEESSEQDL FPEPTLSRPL FDVAIIIDKI
8610 8620 8630 8640 8650
TQKHRVVFRI SHALYDGATL HRVWTALEAL TTGQAPGYFA PIGAYLQSLQ
8660 8670 8680 8690 8700
AQTTSETEDY WQQLVDGATI SCVGTSSEPK VSRLGHVSGP PITLPESKQS
8710 8720 8730 8740 8750
HFNLAVAVKA AWALVFGHHA NTHDIVFADV MTGRNTVDSS VADVVSCCAR
8760 8770 8780 8790 8800
AVPCRITYEP DWTVEKLLDL TKQQQVNSMR HEGLELQQIA QRYMGWPQDD
8810 8820 8830 8840 8850
HEEAPDMRVS MTNYVKTSIR DLLLGATQYR RATAGFQNAY ASADFSVDSV
8860 8870 8880 8890 8900
EESDGSLSVS IAYAADRISE QLAATLLHRT RVTLEKMMEN PRSTVGHLLK

QLD
Length:8,903
Mass (Da):977,655
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6142E7C18D693286
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB862312 Genomic DNA Translation: BAO73252.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB862312 Genomic DNA Translation: BAO73252.1

3D structure databases

SMRiA0A024F910
ModBaseiSearch...

Family and domain databases

Gene3Di1.10.1200.10, 7 hits
3.30.559.10, 10 hits
3.40.50.12780, 6 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 6 hits
PF00668, Condensation, 10 hits
PF00550, PP-binding, 7 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 6 hits
SUPFAMiSSF47336, SSF47336, 7 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 6 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 6 hits
PS50075, CARRIER, 7 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVLMS_LECSP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024F910
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2016
Last sequence update: July 9, 2014
Last modified: December 11, 2019
This is version 22 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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