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Protein

2-dehydropantoate 2-reductase

Gene

apbA

Organism
Escherichia coli O145:H28 str. RM12581
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.UniRule annotation

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
  2. 2-dehydropantoate 2-reductase (apbA)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processPantothenate biosynthesisUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydropantoate 2-reductaseUniRule annotation (EC:1.1.1.169UniRule annotation)
Alternative name(s):
Ketopantoate reductaseUniRule annotation
Gene namesi
Name:apbAImported
ORF Names:ECRM12581_2055Imported
OrganismiEscherichia coli O145:H28 str. RM12581Imported
Taxonomic identifieri1248823 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000025231 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliA0A023YSZ4
SMRiA0A023YSZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 143ApbAInterPro annotationAdd BLAST141
Domaini168 – 289ApbA_CInterPro annotationAdd BLAST122

Sequence similaritiesi

Belongs to the ketopantoate reductase family.UniRule annotation

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR003710 ApbA
IPR013752 KPA_reductase
IPR013332 KPR_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02558 ApbA, 1 hit
PF08546 ApbA_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00745 apbA_panE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A023YSZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITVLGCGA LGQLWLTALC KQGHEVQGWL RVPQPYCSVN LVETDGSIFN
60 70 80 90 100
ESLTANDPDF LATSDLLLVT LKAWQVSDAV KSLASTLPVT TPILLIHNGM
110 120 130 140 150
GTIEELQNIQ QPLLMGTTTH AARRDGNVII HVANGITHIG PARQQDGDYS
160 170 180 190 200
YLADILQTVL PDVAWHNNIR AELWRKLAVN CVINPLTAIW NCPNGELRHH
210 220 230 240 250
PQEIMQICEE VAAVIEREGH HTSAEDLRDY VMQVIDATAE NISSMLQDIR
260 270 280 290 300
ALRHTEIDYI NGFLLRRARA HGIAVPENTR LFEMVKRKES EYERIGTGLP

RPW
Length:303
Mass (Da):33,871
Last modified:July 9, 2014 - v1
Checksum:iED7027BFE6F86D6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP007136 Genomic DNA Translation: AHY68941.1
RefSeqiWP_000705865.1, NZ_CP007136.1

Genome annotation databases

EnsemblBacteriaiAHY68941; AHY68941; ECRM12581_2055
PATRICifig|1248823.7.peg.418

Similar proteinsi

Entry informationi

Entry nameiA0A023YSZ4_ECOLX
AccessioniPrimary (citable) accession number: A0A023YSZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: February 28, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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