UniProtKB - A0A023R6I9 (A0A023R6I9_HUMAN)
Protein
Cytochrome c oxidase subunit 1
Gene
COX1
Organism
Homo sapiens (Human)
Status
Functioni
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation
Catalytic activityi
- 4 [Fe(II)cytochrome c] + 4 H+ + O2 = 4 [Fe(III)cytochrome c] + 2 H2OUniRule annotationSAAS annotationEC:1.9.3.1UniRule annotationSAAS annotation
: oxidative phosphorylation Pathwayi
This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotationSAAS annotationView all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.
GO - Molecular functioni
- cytochrome-c oxidase activity Source: UniProtKB-EC
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- aerobic respiration Source: InterPro
- oxidative phosphorylation Source: UniProtKB-UniPathway
Keywordsi
Molecular function | OxidoreductaseUniRule annotationSAAS annotation |
Biological process | Electron transport, Respiratory chainUniRule annotationSAAS annotation, Transport |
Ligand | CopperUniRule annotationSAAS annotation, HemeUniRule annotationSAAS annotation, Iron, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:COX1Imported |
Encoded oni | MitochondrionImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respiratory chain complex IV Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 18 – 37 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 57 – 83 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 104 – 128 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 148 – 171 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 183 – 210 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 243 – 261 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 268 – 291 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 303 – 325 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 337 – 359 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 379 – 400 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 412 – 430 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 450 – 473 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 511 | COX1InterPro annotationAdd BLAST | 511 |
Sequence similaritiesi
Belongs to the heme-copper respiratory oxidase family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisSAAS annotationPhylogenomic databases
eggNOGi | KOG4769 Eukaryota COG0843 LUCA |
Family and domain databases
CDDi | cd01663 Cyt_c_Oxidase_I, 1 hit |
Gene3Di | 1.20.210.10, 1 hit |
InterProi | View protein in InterPro IPR023616 Cyt_c_oxase-like_su1_dom IPR036927 Cyt_c_oxase-like_su1_sf IPR000883 Cyt_C_Oxase_1 IPR023615 Cyt_c_Oxase_su1_BS IPR033944 Cyt_c_oxase_su1_dom |
PANTHERi | PTHR10422 PTHR10422, 1 hit |
Pfami | View protein in Pfam PF00115 COX1, 1 hit |
PRINTSi | PR01165 CYCOXIDASEI |
SUPFAMi | SSF81442 SSF81442, 1 hit |
PROSITEi | View protein in PROSITE PS50855 COX1, 1 hit PS00077 COX1_CUB, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A023R6I9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRAE LGQPGNLLGN
60 70 80 90 100
DHIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM
110 120 130 140 150
SFWLLPPSLL LLLASAMVEA GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL
160 170 180 190 200
HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP
210 220 230 240 250
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG
260 270 280 290 300
FGMVSHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD
310 320 330 340 350
TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV
360 370 380 390 400
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF
410 420 430 440 450
SGYTLDQTYA KIHFTIMFIG VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW
460 470 480 490 500
XILSSVGSFI SLTAVMLMIF MIWEAFASKR KVLMVEEPSM NLEWLYGCPP
510
PYHTFEEPVY MKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ446756 Genomic DNA Translation: AHX55884.1 KJ446768 Genomic DNA Translation: AHX56040.1 KJ446771 Genomic DNA Translation: AHX56079.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ446756 Genomic DNA Translation: AHX55884.1 KJ446768 Genomic DNA Translation: AHX56040.1 KJ446771 Genomic DNA Translation: AHX56079.1 |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A023R6I9 |
Phylogenomic databases
eggNOGi | KOG4769 Eukaryota COG0843 LUCA |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
Family and domain databases
CDDi | cd01663 Cyt_c_Oxidase_I, 1 hit |
Gene3Di | 1.20.210.10, 1 hit |
InterProi | View protein in InterPro IPR023616 Cyt_c_oxase-like_su1_dom IPR036927 Cyt_c_oxase-like_su1_sf IPR000883 Cyt_C_Oxase_1 IPR023615 Cyt_c_Oxase_su1_BS IPR033944 Cyt_c_oxase_su1_dom |
PANTHERi | PTHR10422 PTHR10422, 1 hit |
Pfami | View protein in Pfam PF00115 COX1, 1 hit |
PRINTSi | PR01165 CYCOXIDASEI |
SUPFAMi | SSF81442 SSF81442, 1 hit |
PROSITEi | View protein in PROSITE PS50855 COX1, 1 hit PS00077 COX1_CUB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A023R6I9_HUMAN | |
Accessioni | A0A023R6I9Primary (citable) accession number: A0A023R6I9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | May 8, 2019 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |