UniProtKB - A0A023GPI8 (LECA_CANBL)
Protein
Lectin alpha chain
Gene
N/A
Organism
Canavalia boliviana
Status
Functioni
D-mannose/D-glucose-binding lectin (PubMed:24865454). Has anti-inflammatory activity in animal models when applied intravenously (PubMed:24865454). Has antinociceptive activity in mice when applied intravenously (PubMed:19705102).2 Publications
Miscellaneous
Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 8 | Manganese1 Publication | 1 | |
Metal bindingi | 10 | Calcium1 Publication | 1 | |
Metal bindingi | 10 | Manganese1 Publication | 1 | |
Metal bindingi | 12 | Calcium; via carbonyl oxygen1 Publication | 1 | |
Binding sitei | 12 | Carbohydrate1 Publication | 1 | |
Metal bindingi | 14 | Calcium1 Publication | 1 | |
Binding sitei | 14 | Carbohydrate1 Publication | 1 | |
Metal bindingi | 19 | Calcium1 Publication | 1 | |
Metal bindingi | 19 | Manganese1 Publication | 1 | |
Metal bindingi | 24 | Manganese1 Publication | 1 | |
Metal bindingi | 208 | CalciumBy similarity | 1 | |
Binding sitei | 228 | Carbohydrate; via amide nitrogenBy similarity | 1 |
GO - Molecular functioni
- mannose binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | Calcium, Lectin, Manganese, Mannose-binding, Metal-binding |
Protein family/group databases
UniLectini | A0A023GPI8 |
Names & Taxonomyi
Protein namesi | Recommended name: Lectin alpha chain1 PublicationShort name: CboL2 Publications Cleaved into the following 2 chains: Lectin beta chain1 Publication Lectin gamma chain1 Publication |
Organismi | Canavalia bolivianaImported |
Taxonomic identifieri | 232300 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Fabales › Fabaceae › Papilionoideae › 50 kb inversion clade › NPAAA clade › indigoferoid/millettioid clade › Phaseoleae › Canavalia |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000436146 | 1 – 237 | Lectin alpha chain1 PublicationAdd BLAST | 237 | |
ChainiPRO_0000436147 | 1 – 118 | Lectin beta chain1 PublicationAdd BLAST | 118 | |
ChainiPRO_0000436148 | 119 – 237 | Lectin gamma chain1 PublicationAdd BLAST | 119 |
Interactioni
Subunit structurei
Homodimer and homotetramer. Oligomerization is pH-dependent with homotetramers forming at pH 4 and above.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | A0A023GPI8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 99 – 100 | Carbohydrate binding1 Publication | 2 |
Sequence similaritiesi
Belongs to the leguminous lectin family.Curated
Family and domain databases
CDDi | cd06899, lectin_legume_LecRK_Arcelin_ConA, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000985, Lectin_LegA_CS IPR019825, Lectin_legB_Mn/Ca_BS IPR001220, Legume_lectin_dom |
Pfami | View protein in Pfam PF00139, Lectin_legB, 2 hits |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS00308, LECTIN_LEGUME_ALPHA, 1 hit PS00307, LECTIN_LEGUME_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A0A023GPI8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
ADTIVAVELD TYPNTDIGDP SYPHIGIDIK SVRSKKTAKW NMQNGKVGTA
60 70 80 90 100
HIIYNSVGKR LSAVVSYPNG DSATVSYDVD LDNVLPEWVR VGLSATTGLY
110 120 130 140 150
KETNTILSWS FTSKLKSNST HETNALHFMF NQFSKDQKDL ILQGDATTGR
160 170 180 190 200
DGNLELTRVS SNGSPQGSSV GRALFYAPVH IWESSAVVAS FDATFTFLIK
210 220 230
SSDSHPADGI AFFISNIDSS IPSGSTGRLL GLFPDAN
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4K1Y | X-ray | 2.50 | A/B/C/D | 1-237 | [»] | |
4K1Z | X-ray | 2.30 | A/B/C/D | 1-237 | [»] | |
4K20 | X-ray | 3.40 | A/B | 1-237 | [»] | |
4K21 | X-ray | 1.60 | A | 1-237 | [»] | |
SMRi | A0A023GPI8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
UniLectini | A0A023GPI8 |
Family and domain databases
CDDi | cd06899, lectin_legume_LecRK_Arcelin_ConA, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000985, Lectin_LegA_CS IPR019825, Lectin_legB_Mn/Ca_BS IPR001220, Legume_lectin_dom |
Pfami | View protein in Pfam PF00139, Lectin_legB, 2 hits |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS00308, LECTIN_LEGUME_ALPHA, 1 hit PS00307, LECTIN_LEGUME_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LECA_CANBL | |
Accessioni | A0A023GPI8Primary (citable) accession number: A0A023GPI8 Secondary accession number(s): P86474 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 11, 2016 |
Last sequence update: | June 11, 2014 | |
Last modified: | April 7, 2021 | |
This is version 32 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families