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Entry version 39 (22 Apr 2020)
Sequence version 1 (11 Jun 2014)
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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

EURHEDRAFT_459991

Organism
Aspergillus ruber CBS 135680
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationImported, Transferase
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.354UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:EURHEDRAFT_459991Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus ruber CBS 135680Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1388766 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000019804 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the COMPASS (Set1C) complex.

UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1092 – 1209SETInterPro annotationAdd BLAST118
Domaini1218 – 1234Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 46DisorderedSequence analysisAdd BLAST21
Regioni58 – 142DisorderedSequence analysisAdd BLAST85
Regioni181 – 207DisorderedSequence analysisAdd BLAST27
Regioni366 – 418DisorderedSequence analysisAdd BLAST53
Regioni519 – 544DisorderedSequence analysisAdd BLAST26
Regioni612 – 647DisorderedSequence analysisAdd BLAST36
Regioni680 – 740DisorderedSequence analysisAdd BLAST61
Regioni767 – 861DisorderedSequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 46PolyampholyteSequence analysisAdd BLAST20
Compositional biasi68 – 142PolarSequence analysisAdd BLAST75
Compositional biasi186 – 207PolyampholyteSequence analysisAdd BLAST22
Compositional biasi366 – 388PolyampholyteSequence analysisAdd BLAST23
Compositional biasi529 – 544PolyampholyteSequence analysisAdd BLAST16
Compositional biasi626 – 647PolarSequence analysisAdd BLAST22
Compositional biasi680 – 724PolyampholyteSequence analysisAdd BLAST45
Compositional biasi725 – 740PolarSequence analysisAdd BLAST16
Compositional biasi767 – 783PolarSequence analysisAdd BLAST17
Compositional biasi784 – 823PolyampholyteSequence analysisAdd BLAST40

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004391_1_0_1

Database of Orthologous Groups

More...
OrthoDBi
1017537at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR035979 RBD_domain_sf
IPR017111 Set1
IPR024636 SET_assoc
IPR001214 SET_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11764 N-SET, 1 hit
PF00856 SET, 1 hit
PF11767 SET_assoc, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037104 Histone_H3-K4_mtfrase_Set1_fun, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50868 POST_SET, 1 hit
PS51572 SAM_MT43_1, 1 hit
PS50280 SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A017SBD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSSAGFAD FFPTAPSVLQ QKRFRAAQEL PHPKLHNEHE SNEERPACFV
60 70 80 90 100
EPNTVKDVMH GGTFAQPGSE SHDESAKVSF ETTGIGSTSS MSTGPSASGS
110 120 130 140 150
SLSQIGPSHL NEMHTDTLTP LTNVESSPPC KSSPQPSKIM NGVTNANQVK
160 170 180 190 200
SRGEEQRVAI TPLHTPPTPQ PQEHTIENRV SGYKLVYDPD SDRRPSSSSK
210 220 230 240 250
DRRRKPEYVD IVFNGQNGCP PDPRLAIPNY TRGAGCKQKP KYRPSPYMLK
260 270 280 290 300
SWPYDSATTI GPGPPTQIAV TGFDPLTPIA PISALFSSFG EITEINNRTD
310 320 330 340 350
PITGRFLGVC SIRYKDTSSF RGGSPILAAS AAKRAYLECK KEQRIGTRRI
360 370 380 390 400
RVELDRDGIL AEKIVSKATD PRRLGHKKAE ETKPDPQSKR NEPPPTAPKG
410 420 430 440 450
PSGRSSMRPM PAVPEGPRAV FSKPAVPSLV EETPVLNQIK RDPYIFVAHC
460 470 480 490 500
YVPVLSTTVP HLKKRLKLFN WKDIRCDKTG YYIIFENSRR GEEETERCYK
510 520 530 540 550
ICHMKPLFTY IMNMESQPYG NPNYERSPSP ERLEAEKREK AEAERLEKEA
560 570 580 590 600
KIDVEEEKKL RVIDLDPCRE VLTMIIRDLK DKLLEDVKSR IAAPALYDYL
610 620 630 640 650
DPDRHAAKRK ELGISDPEGT RQPTFRLGFD ASSETPDSRS ELSNVQRPFG
660 670 680 690 700
TSNLNVLALP RIRKAHRLNR ADAFLDERRK QPVRRREVRP LYHRLQQLHD
710 720 730 740 750
HDDSDDDQRT PFTRDTDEQE SRPLSRMSSI DSGSDNDEQS MLGTLQTSVT
760 770 780 790 800
ELPVRQYYNE TEGDDIATES AANSQSNDAS GLSPMSRKRK RINEDHEARK
810 820 830 840 850
RQREDEEPFA INSVNKPEDE HTKSPVSLAT GGNRTVTDGP PDIVLSSTIL
860 870 880 890 900
EEDQSSKDPS ERCGLEASMY EKDHAEKVHV FGDGIDEVDQ PEESKIEVEW
910 920 930 940 950
RVSNDEPRPT VLDDEAIILD LDGWQNLIKD EEDLHFLRDV LASQPKANLG
960 970 980 990 1000
NLAAWAWRQK EIKALNRPGD LGPVHEETII HGYYVVNATG AARTEGRKRI
1010 1020 1030 1040 1050
LESEKSKYLP HRIKVQKARE EREAKAKSDP QATAAEAARI AAAKTISKST
1060 1070 1080 1090 1100
SRSTRVNNRR LIADINAQKQ ALPMQSGDGD VLRFNQLKKR KKPVRFARSA
1110 1120 1130 1140 1150
IHNWGLYAEE NISANDMIIE YVGEKVRQQV ADMRERQYLK SGIGSSYLFR
1160 1170 1180 1190 1200
IDENTVIDAT KRGGIARFIN HSCTPNCTAK IIKVDGSKRI VIYALRDIER
1210 1220 1230
DEELTYDYKF EREWDSDDRI PCLCGSTGCK GFLN
Length:1,234
Mass (Da):138,889
Last modified:June 11, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51DBA9FBC92F39F3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KK088431 Genomic DNA Translation: EYE93510.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EYE93510; EYE93510; EURHEDRAFT_459991

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KK088431 Genomic DNA Translation: EYE93510.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblFungiiEYE93510; EYE93510; EURHEDRAFT_459991

Phylogenomic databases

HOGENOMiCLU_004391_1_0_1
OrthoDBi1017537at2759

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR035979 RBD_domain_sf
IPR017111 Set1
IPR024636 SET_assoc
IPR001214 SET_dom
PfamiView protein in Pfam
PF11764 N-SET, 1 hit
PF00856 SET, 1 hit
PF11767 SET_assoc, 1 hit
PIRSFiPIRSF037104 Histone_H3-K4_mtfrase_Set1_fun, 2 hits
SMARTiView protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS51572 SAM_MT43_1, 1 hit
PS50280 SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A017SBD4_9EURO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A017SBD4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: April 22, 2020
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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