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Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Streptomyces sp. PRh5
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Aspartokinase (Z951_26105)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. 4-hydroxy-tetrahydrodipicolinate synthase (dapA), 4-hydroxy-tetrahydrodipicolinate synthase (dapA), 4-hydroxy-tetrahydrodipicolinate synthase (dapA)
  4. 4-hydroxy-tetrahydrodipicolinate reductase (dapB)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Aspartokinase (Z951_26105)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Z951_11165)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (Z951_26105)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Z951_11165)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (Z951_11160)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97PhosphateUniRule annotation1
Active sitei127Acyl-thioester intermediateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Binding sitei246SubstrateUniRule annotation1
Active sitei253Proton acceptorUniRule annotation1
Binding sitei320NADPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 12NADPUniRule annotation4
Nucleotide bindingi37 – 38NADPUniRule annotation2
Nucleotide bindingi157 – 158NADPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00016

UPA00050;UER00463

UPA00051;UER00464

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
Short name:
ASA dehydrogenaseUniRule annotation
Short name:
ASADHUniRule annotation
Alternative name(s):
Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:asdUniRule annotation
ORF Names:Z951_00335Imported
OrganismiStreptomyces sp. PRh5Imported
Taxonomic identifieri1158056 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000019949 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 117Semialdhyde_dhInterPro annotationAdd BLAST116

Sequence similaritiesi

Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_02121 ASADH, 1 hit
InterProiView protein in InterPro
IPR000319 Asp-semialdehyde_DH_CS
IPR012080 Asp_semialdehyde_DH
IPR005986 Asp_semialdehyde_DH_beta
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
IPR012280 Semialdhyde_DH_dimer_dom
PfamiView protein in Pfam
PF01118 Semialdhyde_dh, 1 hit
PF02774 Semialdhyde_dhC, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01296 asd_B, 1 hit
PROSITEiView protein in PROSITE
PS01103 ASD, 1 hit

Sequencei

Sequence statusi: Complete.

A0A014LVW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIGIVGATG QVGGVMRRVL AERDFPAEQL RLFASARSAG RTLPWRGTEI
60 70 80 90 100
TVEDAATADY SGLDIVLFSA GGATSKALAE KVAAQGPVVI DNSSAWRMDP
110 120 130 140 150
EVPLVVAEVN PHAAVDRPKG IIANPNCTTM AAMPVLRPLH AEAGLTALVA
160 170 180 190 200
TTYQAVSGSG LSGVAELDGQ IRKTADRAAE LTHDGAAVDF PEPGVYARPI
210 220 230 240 250
AFNVLPMAGK IVDDGRFETD EEQKLRNESR KILEIPELKV SGTCVRVPVF
260 270 280 290 300
TGHSLQVNLR FERPISVERA YELLAAAPGV ALSEIPTPLQ AAGQDPSYVG
310 320 330 340
RIRVDETVEH GLALFLSNDN LRKGAALNAV QIAELVAADL T
Length:341
Mass (Da):36,099
Last modified:June 11, 2014 - v1
Checksum:i6078BCA7BF7A07AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JABQ01000001 Genomic DNA Translation: EXU69959.1
RefSeqiWP_037945886.1, NZ_JABQ01000001.1

Genome annotation databases

EnsemblBacteriaiEXU69959; EXU69959; Z951_00335
PATRICifig|1158056.3.peg.68

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JABQ01000001 Genomic DNA Translation: EXU69959.1
RefSeqiWP_037945886.1, NZ_JABQ01000001.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEXU69959; EXU69959; Z951_00335
PATRICifig|1158056.3.peg.68

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00016

UPA00050;UER00463

UPA00051;UER00464

Family and domain databases

HAMAPiMF_02121 ASADH, 1 hit
InterProiView protein in InterPro
IPR000319 Asp-semialdehyde_DH_CS
IPR012080 Asp_semialdehyde_DH
IPR005986 Asp_semialdehyde_DH_beta
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
IPR012280 Semialdhyde_DH_dimer_dom
PfamiView protein in Pfam
PF01118 Semialdhyde_dh, 1 hit
PF02774 Semialdhyde_dhC, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01296 asd_B, 1 hit
PROSITEiView protein in PROSITE
PS01103 ASD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A014LVW8_9ACTN
AccessioniPrimary (citable) accession number: A0A014LVW8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: May 23, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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