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Entry version 44 (26 Feb 2020)
Sequence version 1 (11 Jun 2014)
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Protein

Histidine kinase

Gene

luxQ_2

Organism
Candidatus Accumulibacter sp. SK-11
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation EC:2.7.13.3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseSAAS annotationImported, Transferase
Biological processTwo-component regulatory systemSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine kinaseSAAS annotation (EC:2.7.13.3SAAS annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:luxQ_2Imported
ORF Names:AW07_03882Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandidatus Accumulibacter sp. SK-11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1454000 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaCandidatus Accumulibacterunclassified Candidatus Accumulibacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000020226 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei276 – 298HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6624-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei832PhosphohistidinePROSITE-ProRule annotation1

Keywords - PTMi

PhosphoproteinPROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini295 – 347HAMPInterPro annotationAdd BLAST53
Domaini369 – 592Histidine kinaseInterPro annotationAdd BLAST224
Domaini613 – 730Response regulatoryInterPro annotationAdd BLAST118
Domaini793 – 886HPtInterPro annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni737 – 771DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili335 – 362Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00082 HisKA, 1 hit
cd00088 HPT, 1 hit
cd00156 REC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.160, 1 hit
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011006 CheY-like_superfamily
IPR029150 dCache_3
IPR003660 HAMP_dom
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR036641 HPT_dom_sf
IPR029151 Sensor-like_sf
IPR004358 Sig_transdc_His_kin-like_C
IPR008207 Sig_transdc_His_kin_Hpt_dom
IPR001789 Sig_transdc_resp-reg_receiver

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14827 dCache_3, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF01627 Hpt, 1 hit
PF00072 Response_reg, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00344 BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00304 HAMP, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00073 HPT, 1 hit
SM00448 REC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103190 SSF103190, 1 hit
SSF47226 SSF47226, 1 hit
SSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 1 hit
SSF55874 SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50885 HAMP, 1 hit
PS50109 HIS_KIN, 1 hit
PS50894 HPT, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A011MKX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFRPSISFS LVILFAVLAA ASHWSAFLVS EDALSATVRS GEVDRMRTIG
60 70 80 90 100
RVIEELIAEQ SRRARLAARL TASIDKLGAS LHNPGVASTA AIRELLTQSM
110 120 130 140 150
TISGLAEMQV TNSQEIVVHR AHDPQRHGDH SALWGVFEAL AGASQLATSR
160 170 180 190 200
ADGVLVLHAI EPVRWHAKTV GTLAAGVRID AELLRRLARD LGTEISLVAR
210 220 230 240 250
SGVLLAGSAE TPYALDQTAI DAALLQKIPV YRHHPADART LGYLPLTIVD
260 270 280 290 300
DAYIVVAALD SSMPYQMLDE ARGRSLAYLL LILAVSTLLG LVLVRWILRP
310 320 330 340 350
LRQLRQRSAS LALTLTGKEI ETPATDEVSA VVTVLDTLTE RLVQRNEELV
360 370 380 390 400
EAKRAADQAS DAKSQFLSNM SHEIRTPLNG ILGMAEMLAR TPLSPTQARY
410 420 430 440 450
LQAISGSGQS LHALLGDILD LAKIEAGKVV TEEIDFDLQP LLSGLADSFR
460 470 480 490 500
ELASTNGNLM TTDFRLPARV ELRGDPTRVR QILANLLGNA NKFTKGGTLT
510 520 530 540 550
LGALITEAPA PDRRIWLRFT VRDTGIGIAP KALARLFQPF VQADQTTTRR
560 570 580 590 600
FGGSGLGLVI CRHLASLLGG TITADSQVGR GSTFIVELPF GEARAPLAAA
610 620 630 640 650
RDAAPATQKI GGRVLVAEDN PVNQSVIEAM LRELGVDACV VGNGALAVAA
660 670 680 690 700
LRSTAYDLVL MDCQMPVMDG YAATAAIRAE PGPLARVPII ALTANTLPED
710 720 730 740 750
RQHCLTAGMN DYLSKPVRLE TLATALRRWL PPGSVTGPGT AAASAAGELP
760 770 780 790 800
PAAEAAPPAS ASAAPPATAD AAPAPVLDRS ALLDNPNFGH STSGNLIERV
810 820 830 840 850
IGIYLENTPR LLAAISDGLP AQTWPEVTRA AHSLKSSSAT IGLHRVAAVA
860 870 880 890
ARIESLAREH DAAAVADELP GLQTECAQGI PELQAELARL STGAPPP
Length:897
Mass (Da):94,941
Last modified:June 11, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C1E5C82FE12F504
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JFAW01000034 Genomic DNA Translation: EXI70673.1

Genome annotation databases

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1454000.3.peg.3183

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JFAW01000034 Genomic DNA Translation: EXI70673.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

PATRICifig|1454000.3.peg.3183

Family and domain databases

CDDicd00082 HisKA, 1 hit
cd00088 HPT, 1 hit
cd00156 REC, 1 hit
Gene3Di1.20.120.160, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR029150 dCache_3
IPR003660 HAMP_dom
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR036641 HPT_dom_sf
IPR029151 Sensor-like_sf
IPR004358 Sig_transdc_His_kin-like_C
IPR008207 Sig_transdc_His_kin_Hpt_dom
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF14827 dCache_3, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF01627 Hpt, 1 hit
PF00072 Response_reg, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00304 HAMP, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00073 HPT, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF103190 SSF103190, 1 hit
SSF47226 SSF47226, 1 hit
SSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50885 HAMP, 1 hit
PS50109 HIS_KIN, 1 hit
PS50894 HPT, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A011MKX1_9PROT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A011MKX1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: February 26, 2020
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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