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Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Acinetobacter baumannii 951631
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotationSAAS annotation

Pathwayi: LPS lipid A biosynthesis

This protein is involved in the pathway LPS lipid A biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway LPS lipid A biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei242Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processLipid A biosynthesisUniRule annotationSAAS annotation, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00973

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:lpxDUniRule annotationImported
ORF Names:J552_1133Imported
OrganismiAcinetobacter baumannii 951631Imported
Taxonomic identifieri1310653 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000020632 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homotrimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA0A009SCV6
SMRiA0A009SCV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 92LpxDInterPro annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili331 – 351Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatUniRule annotationSAAS annotation

Family and domain databases

CDDicd03352 LbH_LpxD, 1 hit
HAMAPiMF_00523 LpxD, 1 hit
InterProiView protein in InterPro
IPR001451 Hexapep
IPR007691 LpxD
IPR011004 Trimer_LpxA-like_sf
IPR020573 UDP_GlcNAc_AcTrfase_non-rep
PANTHERiPTHR43378 PTHR43378, 1 hit
PfamiView protein in Pfam
PF00132 Hexapep, 3 hits
PF14602 Hexapep_2, 1 hit
PF04613 LpxD, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01853 lipid_A_lpxD, 1 hit

Sequencei

Sequence statusi: Complete.

A0A009SCV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVQQYRLDE LAHLVKGELI GEGSLQFSNL ASLENAEVNH LTFVNGEKHL
60 70 80 90 100
DQAKVSRAGA YIVTAALKEH LPEKDNFIIV DNPYLAFAIL THVFDKKISS
110 120 130 140 150
TGIESTAQIH PSAVISETAY IGHYVVIGEN CVVGDNTVIQ SHTKLDDNVE
160 170 180 190 200
VGKDCFIDSH VTITGGSKLR DRVRIHSSTV IGGEGFGFAP YQGKWHRIAQ
210 220 230 240 250
LGSVLIGNDV RIGSNCSIDR GALDNTILED GVIIDNLVQI AHNVHIGSNT
260 270 280 290 300
AIAAKCGIAG STKIGKNCIL AGACGVAGHL SIADNVTLTG MSMVTKNISE
310 320 330 340 350
AGTYSSGTGL FENNHWKKTI VRLRQLADVP LTQITKRLDH IQAQIESLES

TFNLRK
Length:356
Mass (Da):38,400
Last modified:June 11, 2014 - v1
Checksum:iA653D4C4FB2A3692
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JEXI01000009 Genomic DNA Translation: EXC39794.1
RefSeqiWP_000868103.1, NZ_JEXI01000009.1

Genome annotation databases

EnsemblBacteriaiEXC39794; EXC39794; J552_1133
PATRICifig|1310653.3.peg.1116

Similar proteinsi

Entry informationi

Entry nameiA0A009SCV6_ACIBA
AccessioniPrimary (citable) accession number: A0A009SCV6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: December 20, 2017
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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