Ajellomyces capsulate (syn. Histoplasma capsulatum) is the causal agent of Histoplasmosis, also known as Darling's disease. Found throughout the world commonly in bat and bird droppings, the disease is contracted by breathing in the fungal spores. Most people do not display any symptoms and are unaware they are infected, but in immunocompromised individuals the disease can spread from the lungs to other organs of the body and can be fatal if left untreated.

The assembled nuclear genome of A. capsulate strain NAm1 is approximately 33 Mb and contains over 9,300 predicted protein-coding genes. Comparisons with its distant pathogenic relatives the Coccidioides, found that although A. capsulate does not display the protease expansions observed in the genomes of the Coccidioides it has undergone a similar reduction in plant decay enzymes.