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StatusReference proteome
Gene counti - Download one protein sequence per gene (FASTA)
Proteome IDiUP000008524
Taxonomy185431 - Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Strain927/4 GUTat10.1
Last modifiedApril 27, 2018
Genome assembly and annotationi GCA_000002445.1 from ENA/EMBL

Trypanosoma brucei is a species of parasitic protozoan which causes African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals. It is endemic to 37 countries in Sub-Saharan Africa. The parasite is transmitted by the bloodsucking tsetse fly vector (Glossina sp.), and the resulting infection is usually fatal unless treated. There are three subspecies which cause different types of trypanosomiasis: T. brucei brucei, T. brucei gambiense, and T. brucei rhodiense. Although T. brucei brucei does not normally cause infection in humans, strain 927 is commonly used as a laboratory model for studies of trypanosomiasis.

The 28 Mb genome was first released in 2005, and contains approximately 9000 protein-coding genes. The karyotype is unusual, consisting of 11 large megabase-size chromosomes (0.9-5.7 Mb) and numerous smaller chromosomes (intermediate class, 300-900 kb, and minichromosome class, 50-100 kb). Approximately 10-20% of the genome is contained by the intermediate and minichromosomes.


Component nameGenome Accession(s)
Chromosome 1472
Chromosome 2281
Chromosome 3520
Chromosome 4526
Chromosome 5435
Chromosome 6473
Chromosome 7715
Chromosome 8769
Chromosome 91201
Chromosome 101514
Chromosome 11 Scaffold 11683
Chromosome 11 Scaffold 211


  1. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    El-Sayed N.M.A.
    Science 2005:416-422(2005) [PubMed] [Europe PMC] [Abstract]
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