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Overview

StatusReference proteome
Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome_redundancy">more...</a>)</p> 8,587
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000008524
Taxonomy185431 - Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Strain927/4 GUTat10.1
Last modifiedJuly 15, 2019
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000002445.1 from ENA/EMBL

Trypanosoma brucei is a species of parasitic protozoan which causes African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals. It is endemic to 37 countries in Sub-Saharan Africa. The parasite is transmitted by the bloodsucking tsetse fly vector (Glossina sp.), and the resulting infection is usually fatal unless treated. There are three subspecies which cause different types of trypanosomiasis: T. brucei brucei, T. brucei gambiense, and T. brucei rhodiense. Although T. brucei brucei does not normally cause infection in humans, strain 927 is commonly used as a laboratory model for studies of trypanosomiasis.

The karyotype of T. brucei brucei is unusual, consisting of 11 large megabase-size chromosomes (0.9-5.7 Mb) and numerous smaller chromosomes (intermediate class, 300-900 kb, and minichromosome class, 50-100 kb). Approximately 10-20% of the genome is contained by the intermediate and minichromosomes.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Proteins
Chromosome 1472
Chromosome 2281
Chromosome 3520
Chromosome 4526
Chromosome 5435
Chromosome 6473
Chromosome 7715
Chromosome 8769
Chromosome 91201
Chromosome 101513
Chromosome 11 Scaffold 11683
Chromosome 11 Scaffold 211

Publications

  1. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    El-Sayed N.M.A.
    Science 2005:416-422(2005) [PubMed] [Europe PMC] [Abstract]
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