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StatusReference proteome
Proteome IDiUP000008220
Taxonomy386415 - Clostridium novyi (strain NT)
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000014125.1 from ENA/EMBL
Pan proteomei This proteome is part of the Clostridium novyi (strain NT) pan proteome (fasta)

Clostridium novyi-NT, a Gram +, spore-forming bacteria, is an experimentally developed attenuated strain of pathogenic C.novyi. To do so, the major systemic toxin gene-containing episome has been deleted. It was created to be used as an bacteriolytic anti-tumor agent. An anaerobic bacterium is ideally suited as an anti-tumor agent as the only hypoxic regions within mammals are tumors. Intravenous injection of C.novyi-NT spores in rabbits and mice has produced anti-tumor effects without excessive toxicity. While the spores are very stable, the vegetative form is very sensitive to oxygen.


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