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Overview

Proteins4,595
Proteome IDiUP000008205
Taxonomy574521 - Escherichia coli O127:H6 (strain E2348/69 / EPEC)
StrainE2348/69 / EPEC
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000026545.1 from ENA/EMBL
Pan proteomei This proteome is part of the Escherichia coli (strain K12) pan proteome (fasta)

Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesising appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material. Strain E2348/69, a phylogroup B2 strain, was isolated in Taunton, England in 1969 and is widely used as a model for EPEC (enteropathogenic Ecoli) strains. It is the first EPEC strain to be fully sequenced. EPEC strains are a leading cause of infantile diarrhea in developing countries. EPEC infections are characterized by attaching and effacing lesions which are characterized by microvilli destruction, intimate adherence of bacteria to the intestinal epithelium, pedestal formation, and aggregation of polarized actin and other elements of the cytoskeleton at sites of bacterial attachment. They do not invade cells or release diffusible toxins. This strain is probably capable of utilizing propanediol as a carbon source.

Componentsi

DownloadView all proteins
Component nameGenome Accession(s)
Proteins
Chromosome4499
Plasmid pMAR290
Plasmid pE2348-29

Publications

  1. "Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69."
    Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.
    J. Bacteriol. 2009:347-354(2009) [PubMed] [Europe PMC] [Abstract]

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