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Overview

Proteinsi4,979
Gene counti - Download one protein sequence per gene (FASTA)
Proteome IDiUP000008199
Taxonomy409438 - Escherichia coli (strain SE11)
StrainSE11
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000010385.1 from ENA/EMBL
Pan proteomei This proteome is part of the Escherichia coli (strain K12) pan proteome (fasta)

Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesizing appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.

Strain SE11, a commensal bacterium, was isolated from the feces of a healthy human adult. It belongs to the E.coli phylogenetic group B1. It possesses more genes involved in the metabolism of carbohydrates as well as genes for adhesion than the laboratory workhorse strain MG1655 (which is no longer able to colonize the human gut). These genes are associated with uptake of available nutrients, allowing E. coli to survive in the intestinal tract rich in oligo- and polysaccharides (adapted from PubMed 18931093).

Componentsi

Component nameGenome Accession(s)
Proteins
Chromosome4659
Plasmid pSE11-1123
Plasmid pSE11-2112
Plasmid pSE11-366
Plasmid pSE11-410
Plasmid pSE11-57
Plasmid pSE11-63

Publications

  1. "Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult."
    Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.
    DNA Res. 2008:375-386(2008) [PubMed] [Europe PMC] [Abstract]
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