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Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome_redundancy">more...</a>)</p> 3,496
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000007969
Taxonomy583346 - Clostridium kluyveri (strain NBRC 12016)
StrainNBRC 12016
Last modifiedJuly 25, 2019
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="">more...</a>)</p> GCA_000010265.1 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) pan proteome (fasta)

Clostridium kluyveri is a Gram-positive, spore-forming bacterium. It is unique among the clostridia as it grows anaerobically on ethanol and acetate as sole energy sources, and has been extensively studied. Fermentation products are butyrate, caproate, and H2. It has been used as a source of enzymes, for example phosphotransacetylase for analytical purposes and enoate reductases for stereospecific hydrogenation reactions. A membrane-bound energy-converting NADH:ferredoxin oxidoreductase and a butyryl-CoA dehydrogenase complex coupling the reduction of crotonyl-CoA to butyryl-CoA with the reduction of ferredoxin represent a new energy-conserving module in anaerobes. The genes for NAD-dependent ethanol dehydrogenase and NAD(P)-dependent acetaldehyde dehydrogenase are located next to genes for microcompartment proteins, suggesting that the two enzymes, which are isolated together in a macromolecular complex, form a carboxysome-like structure. Unique for a strict anaerobe, C. kluyveri harbors three sets of genes predicted to encode for polyketide/nonribosomal peptide synthetase hybrides and one set for a nonribosomal peptide synthetase. The latter is predicted to catalyze the synthesis of a new siderophore, which is formed under iron-deficient growth conditions (modified from PubMed:18218779).

Although strains DSM 555 (CLOK5) and NBRC 12016 (CLOK1, this strain) are purportedly coidentical type strains of Clostridium kluyveri there are differences in the genomic sequences. The DNA record (AC AP009049) says; "The genome sequence of NBRC 12016 strain has the region containing phage-related genes (from 1.93 Mbp to 1.99 Mbp). A similar region occurs in DSM 555 (1.93 Mbp to 2.06 Mbp) but it is not only double the size of the NBRC12016 region, but also a duplicate." Whether these differences are due to errors in sequencing and/or assembly, or due to divergent evolution of the two strains is indeterminate at present (April 2009).

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Plasmid pCKL155


  1. "Complete genome sequence of Clostridium kluyveri and comparative genomics of Clostridia species."
    Inui M., Nonaka H., Shinoda Y., Ikenaga Y., Abe M., Naito K., Vertes A.A., Yukawa H.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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