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Overview

Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome%5Fredundancy">more...</a>)</p> 4,222
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a>. It consists of the characters 'UP' followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000007568
Taxonomy652616 - Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
StrainATCC 35801 / TMC 107 / Erdman
Last modifiedJuly 19, 2020
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000350205.1 from ENA/EMBL full
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) pan proteome (fasta)
Buscoi <p>The Benchmarking Universal Single-Copy Ortholog (BUSCO) assessment tool is used, for eukaryotic and bacterial proteomes, to provide quantitative measures of UniProt proteome data completeness in terms of expected gene content. BUSCO scores include percentages of complete (C) single-copy (S) genes, complete (C) duplicated (D) genes, fragmented (F) and missing (F) genes, as well as the total number of orthologous clusters (n) used in the BUSCO assessment.</p> C:98.7%[S:98.3%,D:0.4%],F:0.7%,M:0.7%,n:743 corynebacteriales_odb10
Completenessi <p>Complete Proteome Detector (CPD) is an algorithm which employs statistical evaluation of the completeness and quality of proteomes in UniProt, by looking at the sizes of taxonomically close proteomes. Possible values are 'Standard', 'Close to Standard' and 'Outlier'.</p> Standard

Acid-fast, obligate aerobic, non-motile, rod-shaped bacterium, this is the causative agent of tuberculosis. Tuberculosis is, to this day, according to the WHO, the leading killer of adults, with approximately 2 million deaths annually worldwide. It is estimated that 8 million people are infected each year. A large part of its success as a pathogen is due to its ability to persist in a dormant or latent form for years or even decades, with a concomitant absence of clinical symptoms. This non-replicating persistent form is refractory to most drugs, it may be induced by hypoxia (oxygen depletion) and/or nitric oxide exposure. Up to one-third of the world's population is thought to be latently infected. An additional problem is the emergence of drug resistant strains, mainly because people do not complete their treatment plans or have been incorrectly treated and so have remained infectious. Mycobacteria have an unusual outer membrane approximately 8 nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

Strain Erdman was isolated from human sputum by W.H. Feldman in 1945, at the Mayo Clinic, Rochester, MN, and deposited with the Trudeau Mycobacterium Culture Collection in 1946. Due to its consistently high virulence, it has been widely used as a standard virulent laboratory strain for virulence and immunization studies. It has a faster in vivo doubling time than two attenuated strains, M. tuberculosis H37Ra and Mycobacterium bovis Bacillus Calmette-Guerin (BCG), and a slightly faster in vivo doubling time than the virulent H37Rv strain in mice (adapted from PMID 22535945).

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Component representationProteins
Chromosome4222

Publications

  1. "Complete annotated genome sequence of Mycobacterium tuberculosis Erdman."
    Miyoshi-Akiyama T., Matsumura K., Iwai H., Funatogawa K., Kirikae T.
    J. Bacteriol. 194:2770-2770(2012) [PubMed] [Europe PMC] [Abstract]
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