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Overview

Proteinsi3,938
Gene counti - Download one protein sequence per gene (FASTA)
Proteome IDiUP000007067
Taxonomy300268 - Shigella boydii serotype 4 (strain Sb227)
StrainSb227
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000012025.1 from ENA/EMBL
Pan proteomei This proteome is part of the Escherichia coli (strain K12) pan proteome (fasta)

Shigella is a Gram-negative, non-sporulating, facultative anaerobe bacterium that causes dysentery or shigellosis in man. Shigella are highly invasive in the colon and the rectum, and are able to proliferate in the host cell cytoplasm, triggering an inflammatory reaction. Shigella was recognized as the etiologic agent for bacillary dysentery in the 1890's, and adopted as a genus in the 1950's and subgrouped into four species. However, a recent genetic study argues that Shigella emerged from multiple independent origins of E.coli 35'000-270'000 years ago and may not constitute a genus. S.boydii is mainly epidemic to the Indian subcontinent. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material. Shigella boydii (strain Sb227) was isolated from epidemics in China during the 1950's. Strain Sb227 harbors one chromosome and one plasmid. The IS-element IS1 is predominant in Sb227. A newly identified ISSbo6 element has be found mainly in the chromosome. Most of its copies are located within the SHI-1, SHI-2 and ipaH pathogenicity islands. It also contains the previously reported SHI-3. It has lost flagellar function due to muations in several different genes.

Componentsi

Component nameGenome Accession(s)
Proteins
Chromosome3815
Plasmid pSB4_227133

Publications

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